Published in J Lipid Res on January 23, 2010
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Genetic determinants of plasma triglycerides. J Lipid Res (2010) 1.63
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) (2010) 1.43
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med (2017) 1.39
Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets. J Biol Chem (2013) 1.14
Sugar consumption, metabolic disease and obesity: The state of the controversy. Crit Rev Clin Lab Sci (2015) 1.00
Hepatic ABCA1 and VLDL triglyceride production. Biochim Biophys Acta (2011) 0.95
Complexities of plasma apolipoprotein C-III metabolism. J Lipid Res (2011) 0.91
Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res (2012) 0.90
The regulation of ApoB metabolism by insulin. Trends Endocrinol Metab (2013) 0.85
Apolipoprotein C-III: a potent modulator of hypertriglyceridemia and cardiovascular disease. Curr Opin Endocrinol Diabetes Obes (2015) 0.83
Low triglyceride levels are associated with a better metabolic control in patients with type 1 diabetes. Diabetol Metab Syndr (2011) 0.82
Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis. Lipids Health Dis (2015) 0.81
Partner in fat metabolism: role of KLFs in fat burning and reproductive behavior. 3 Biotech (2011) 0.81
Secretion of triacylglycerol-poor VLDL particles from McA-RH7777 cells expressing human hepatic lipase. J Lipid Res (2010) 0.79
Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces. J Lipid Res (2013) 0.78
Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph. Physiol Rep (2014) 0.78
Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects. Circ Cardiovasc Genet (2016) 0.77
Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition. J Lipid Res (2017) 0.75
APOC3 Is Not a Predisposing Factor for Fat-Induced Nonalcoholic Fatty Liver Disease in Mice. J Biol Chem (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science (2008) 4.50
Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest (1992) 2.80
Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Arterioscler Thromb Vasc Biol (1999) 2.75
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest (1999) 2.50
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis. J Intern Med (2005) 2.14
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest (1986) 1.96
Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem (1991) 1.70
Rapid turnover of apolipoprotein C-III-containing triglyceride-rich lipoproteins contributing to the formation of LDL subfractions. J Lipid Res (2007) 1.44
Plasma apolipoprotein C-III transport in centrally obese men: associations with very low-density lipoprotein apolipoprotein B and high-density lipoprotein apolipoprotein A-I metabolism. J Clin Endocrinol Metab (2007) 1.38
Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER. J Biol Chem (2003) 1.36
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J Biol Chem (1994) 1.34
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab (2004) 1.29
Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem (2002) 1.25
Plasma kinetics of apoC-III and apoE in normolipidemic and hypertriglyceridemic subjects. J Lipid Res (2000) 1.24
Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E. J Biol Chem (2007) 1.24
Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions. J Lipid Res (2010) 1.21
Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH7777 cells. J Biol Chem (2002) 1.21
Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Metabolism (1979) 1.19
Structure and dynamics of human apolipoprotein CIII. J Biol Chem (2008) 1.18
Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemia. Atherosclerosis (2004) 1.17
The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells. A unified model for the assembly of very low density lipoproteins. J Biol Chem (1999) 1.16
Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. J Clin Invest (1991) 1.15
Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice. J Lipid Res (1996) 1.14
Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly. J Biol Chem (2007) 1.12
Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from McA-RH7777 cells. J Biol Chem (1997) 1.11
Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III. J Lipid Res (1992) 1.10
Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr. J Lipid Res (2000) 1.10
Peptides in membranes: tipping the balance of membrane stability. Trends Biochem Sci (1997) 1.07
Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. Am J Clin Nutr (2008) 1.03
A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein. J Biol Chem (2000) 1.03
Plasma lipoprotein distribution of apoC-III in normolipidemic and hypertriglyceridemic subjects: comparison of the apoC-III to apoE ratio in different lipoprotein fractions. J Lipid Res (1997) 0.99
The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells. J Biol Chem (1998) 0.97
Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase. Biochemistry (2000) 0.93
The assembly of very low density lipoproteins in rat hepatoma McA-RH7777 cells is inhibited by phospholipase A2 antagonists. J Biol Chem (2000) 0.92
Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids. Eur J Biochem (1998) 0.89
Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins. Arterioscler Thromb Vasc Biol (2004) 0.88
Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III. Protein Eng (2002) 0.88
Brefeldin A reversibly inhibits the assembly of apoB containing lipoproteins in McA-RH7777 cells. J Biol Chem (1995) 0.88
ADP-ribosylation factor 1 and its activation of phospholipase D are important for the assembly of very low density lipoproteins. J Biol Chem (2000) 0.86
Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient. J Lipid Res (1994) 0.85
Prediction of signal peptide functional properties: a study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants. Protein Eng (1996) 0.85
The C-terminal helix of human apolipoprotein AII promotes the fusion of unilamellar liposomes and displaces apolipoprotein AI from high-density lipoproteins. Eur J Biochem (1998) 0.82
A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin. J Lipid Res (1997) 0.81
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science (2009) 10.21
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov (2011) 3.43
Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology (2007) 3.29
Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res (2009) 2.74
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest (2006) 2.55
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Intestinal lipid absorption. Am J Physiol Endocrinol Metab (2009) 2.41
Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate. Am J Obstet Gynecol (2013) 2.36
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clin Chem (2011) 2.33
Disruption of tumor neovasculature by microbubble enhanced ultrasound: a potential new physical therapy of anti-angiogenesis. Ultrasound Med Biol (2011) 2.18
Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science (2007) 2.06
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer (2011) 2.01
Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J Biol Chem (2006) 1.99
Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1. Arterioscler Thromb Vasc Biol (2013) 1.95
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution. Biochemistry (2007) 1.94
Concern Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci U S A (2006) 1.92
Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner. Med Phys (2007) 1.90
MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation (2007) 1.83
Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer. Cancer Res (2009) 1.80
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet (2012) 1.77
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. Curr Biol (2011) 1.74
Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. Biochem Biophys Res Commun (2005) 1.74
The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics (2007) 1.70
MicroRNAs associated with metastatic prostate cancer. PLoS One (2011) 1.66
BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med (2012) 1.61
Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis (2009) 1.59
A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein. J Lipid Res (2004) 1.59
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development. Cancer Res (2013) 1.58
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab (2009) 1.57
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med (2005) 1.57
Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls. Carcinogenesis (2012) 1.57
Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila) (2013) 1.56
HysTag--a novel proteomic quantification tool applied to differential display analysis of membrane proteins from distinct areas of mouse brain. Mol Cell Proteomics (2003) 1.52
The proteomic reactor: a microfluidic device for processing minute amounts of protein prior to mass spectrometry analysis. J Proteome Res (2006) 1.51
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem (2008) 1.50
Auxin controls seed dormancy through stimulation of abscisic acid signaling by inducing ARF-mediated ABI3 activation in Arabidopsis. Proc Natl Acad Sci U S A (2013) 1.50
microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells. J Ovarian Res (2014) 1.50
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med (2012) 1.50
Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood (2004) 1.49
Glycoproteomic reactor for human plasma. J Proteome Res (2009) 1.49
Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2. J Mol Cell Biol (2011) 1.48
Multiple functions of microsomal triglyceride transfer protein. Nutr Metab (Lond) (2012) 1.47
Nitrogen-doped graphene quantum dots with oxygen-rich functional groups. J Am Chem Soc (2011) 1.46
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci U S A (2008) 1.45
Airborne particulate matter from livestock production systems: a review of an air pollution problem. Environ Pollut (2009) 1.44
Bis[tris-(ethane-1,2-diamine)nickel(II)] octa-cyanidomolybdate(IV) dihydrate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.44
Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab (2010) 1.44
Knowledge and personal use of menopausal hormone therapy among Chinese obstetrician-gynecologists: results of a survey. Menopause (2014) 1.44
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem (2010) 1.44
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology (2006) 1.44
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Proteomics (2007) 1.43
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) (2010) 1.43
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem (2002) 1.43
Cohort Profile: The China Jintan Child Cohort Study. Int J Epidemiol (2009) 1.43
A novel proteomics approach for the discovery of chromatin-associated protein networks. Mol Cell Proteomics (2008) 1.42
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41
A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells. Biochem Biophys Res Commun (2006) 1.41
The 2'-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med (2012) 1.41
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J Biol Chem (2008) 1.40
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol (2008) 1.40
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. J Lipid Res (2008) 1.39
Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano (2013) 1.39
Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity. Mol Cell Biol (2008) 1.38
Comparison of the sensitivity and specificity of 5 image sets of dual-energy computed tomography for detecting first-pass myocardial perfusion defects compared with positron emission tomography. Medicine (Baltimore) (2014) 1.38
Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget (2014) 1.38
Clock is important for food and circadian regulation of macronutrient absorption in mice. J Lipid Res (2009) 1.36
An electrochemical avenue to green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics. Adv Mater (2010) 1.34
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med (2013) 1.34
Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry. J Proteome Res (2005) 1.34
Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J Lipid Res (2005) 1.33
Microsomal triglyceride transfer protein: a multifunctional protein. Front Biosci (2003) 1.33
Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies. J Virol (2004) 1.32
Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science (2004) 1.31
pFind: a novel database-searching software system for automated peptide and protein identification via tandem mass spectrometry. Bioinformatics (2005) 1.31
Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J Biol Chem (2003) 1.30
LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney. J Lipid Res (2008) 1.30
F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis. Thromb Haemost (2002) 1.29
Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels. J Biol Chem (2007) 1.29
Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients. J Mol Biol (2004) 1.26
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. J Lipid Res (2008) 1.25