Published in Mar Drugs on December 23, 2009
Cytotoxic terpene quinones from marine sponges. Mar Drugs (2010) 1.14
New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics. Evid Based Complement Alternat Med (2013) 1.00
Anti-biofilm compounds derived from marine sponges. Mar Drugs (2011) 0.84
Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata. World J Clin Oncol (2011) 0.79
Synthetic strategies to terpene quinones/hydroquinones. Mar Drugs (2012) 0.77
Natural compounds with P2X7 receptor-modulating properties. Purinergic Signal (2013) 0.77
Natural products as sources of new drugs over the last 25 years. J Nat Prod (2007) 13.98
Natural products as sources of new drugs over the period 1981-2002. J Nat Prod (2003) 8.03
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. J Ethnopharmacol (2006) 4.72
Natural products in drug discovery. Drug Discov Today (2008) 4.46
Drug development from marine natural products. Nat Rev Drug Discov (2008) 4.08
Marine natural products. Nat Prod Rep (2009) 3.41
Drugs from the deep: marine natural products as drug candidates. Drug Discov Today (2003) 3.32
The impact of natural products upon modern drug discovery. Curr Opin Chem Biol (2008) 2.84
Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep (2008) 2.84
Chemistry. The renaissance of natural products as drug candidates. Science (2005) 2.83
Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem (2008) 2.63
Natural products as leads to anticancer drugs. Clin Transl Oncol (2007) 2.31
New aspects of natural products in drug discovery. Trends Microbiol (2007) 2.06
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. J Org Chem (2006) 2.04
Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep (2005) 1.82
Deep-sea natural products. Nat Prod Rep (2008) 1.63
Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. Nat Prod Rep (2009) 1.55
Natural products as a robust source of new drugs and drug leads: past successes and present day issues. Am J Cardiol (2008) 1.36
Marine natural product libraries for high-throughput screening and rapid drug discovery. J Nat Prod (2008) 1.34
New anti-tuberculosis drugs: strategies, sources and new molecules. Curr Med Chem (2009) 1.24
Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs. Antimicrob Agents Chemother (2007) 1.24
Natural products as a screening resource. Curr Opin Chem Biol (2007) 1.23
Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds. Eur J Cancer (2008) 1.14
Natural product growth inhibitors of Mycobacterium tuberculosis. Nat Prod Rep (2006) 1.12
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. Bioorg Med Chem (2007) 1.11
A renaissance in marine pharmacology: from preclinical curiosity to clinical reality. Biochem Pharmacol (2009) 1.08
Modular total synthesis of lamellarin D. J Org Chem (2005) 1.00
Naturally diverse: highlights in versatile synthetic methods enabling target- and diversity-oriented synthesis. Nat Prod Rep (2009) 0.99
Asmarines I, J, and K and nosyberkol: four new compounds from the marine sponge Raspailia sp. J Nat Prod (2004) 0.97
Recent advances in lamellarin alkaloids: isolation, synthesis and activity. Anticancer Agents Med Chem (2008) 0.97
Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana. J Nat Prod (2008) 0.96
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. J Nat Prod (2006) 0.91
Alkaloids as potential anti-tubercular agents. Fitoterapia (2009) 0.90
Agelasine G, a new antileukemic alkaloid from the Okinawan marine sponge Agelas sp. Chem Pharm Bull (Tokyo) (1992) 0.90
Natural products from semi-mangrove flora: source, chemistry and bioactivities. Nat Prod Rep (2008) 0.88
Asmarines A-F, novel cytotoxic compounds from the marine sponge Raspailia species. J Nat Prod (2000) 0.88
Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; identification of hits for visceral leishmaniasis and Chagas disease. Molecules (2009) 0.87
Efficient construction of the clerodane decalin core by an asymmetric Morita-Baylis-Hillman reaction/Lewis acid promoted annulation strategy. Angew Chem Int Ed Engl (2006) 0.87
Antimalarial natural products of marine and freshwater origin. Chem Rec (2009) 0.87
Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana. Can J Physiol Pharmacol (1989) 0.86
Natural product drug discovery: the times have never been better. Chem Biol (2007) 0.85
Asmarines G and H and barekol, three new compounds from the marine sponge Raspailia sp. J Nat Prod (2004) 0.84
Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis. Science (1980) 0.84
Synthesis of 9-substituted tetrahydrodiazepinopurines: studies toward the total synthesis of asmarines. J Org Chem (2005) 0.83
Agelasines H and I, 9-methyladenine-containing diterpenoids from an Agelas sponge. J Nat Prod (1998) 0.83
Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity. Planta Med (2000) 0.81
Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsi J Nat Prod (1998) 0.81
Marine natural products: synthetic aspects. Nat Prod Rep (2009) 0.81
Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a beta-cyclocitral derived substituent. Arch Pharm (Weinheim) (2007) 0.81
Antifouling activity of the sponge metabolite agelasine D and synthesised analogs on Balanus improvisus. Biofouling (2008) 0.81
Doridosine derivatives: binding at adenosine receptors and in vivo effects. Eur J Pharmacol (1993) 0.80
3,7-Dimethylguanine, a new purine from a Philippine sponge Zyzzya fuliginosa. Chem Pharm Bull (Tokyo) (2001) 0.80
Natural products in medicinal chemistry. Bioorg Med Chem (2009) 0.79
Isolation and characterization of 1,3-dimethylisoguanine from the Bermudian sponge Amphimedon viridis. J Nat Prod (1997) 0.79
(-)-Agelasidine A from Agelas clathrodes. Z Naturforsch C (2006) 0.78
New alkaloids from the papua new guinean sponge agelas nakamurai J Nat Prod (1998) 0.76
Synthesis and antimycobacterial activity of agelasine E and analogs. Org Biomol Chem (2005) 0.76
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach. Bioorg Med Chem (2005) 0.76
Mode of inhibition of brain Na+,K+-ATPase by agelasidines and agelasines from a sea sponge. Arch Biochem Biophys (1987) 0.76
Cytotoxic terpene quinones from marine sponges. Mar Drugs (2010) 1.14