Published in Drug Discov Today on June 15, 2003
Assembling the marine metagenome, one cell at a time. PLoS One (2009) 4.10
Complementary and Alternative Medicine, When Rigorous, can be Science. Evid Based Complement Alternat Med (2004) 3.43
Drug discovery from natural sources. AAPS J (2006) 2.76
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48
Automated genome mining for natural products. BMC Bioinformatics (2009) 2.29
A historical overview of natural products in drug discovery. Metabolites (2012) 1.47
Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Mol Biosyst (2008) 1.47
Anticancer drugs from marine flora: an overview. J Oncol (2011) 1.30
Trends in the discovery of new marine natural products from invertebrates over the last two decades--where and what are we bioprospecting? PLoS One (2012) 1.29
Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives. Mar Drugs (2014) 1.19
Marine invertebrate natural products for anti-inflammatory and chronic diseases. Evid Based Complement Alternat Med (2013) 1.15
Commentary on Traditional and Modern Biomedical Prospecting: Part II-The Benefits by Werner E.G. Muller, Heinz C. Schroder, Matthias Wiens, Sanja Perovic-Ottstadt, Renato Batel and Isabel M. Muller: Anti-protozoa and antiviral activities of non-cytotoxic truncated and variant analogues of mussel defensin by P. Roch, A. Beschin and E. Bernard. Evid Based Complement Alternat Med (2004) 1.14
Novel Marine Compounds: Anticancer or Genotoxic? J Biomed Biotechnol (2004) 1.12
Development of novel drugs from marine surface associated microorganisms. Mar Drugs (2010) 1.06
Research and application of marine microbial enzymes: status and prospects. Mar Drugs (2010) 1.05
Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean). J Inflamm (Lond) (2009) 1.00
Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012. Mar Drugs (2015) 1.00
Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals. Mar Drugs (2012) 0.99
Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs. Pharm Res (2006) 0.95
Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Allergic and Infectious Disease Pathology (II). Evid Based Complement Alternat Med (2006) 0.94
FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer. Invest New Drugs (2009) 0.93
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide. Mar Drugs (2010) 0.93
Diversity of marine bacteria producing beta-glucosidase inhibitors. Microb Cell Fact (2013) 0.92
Exploring the Diversity and Antimicrobial Potential of Marine Actinobacteria from the Comau Fjord in Northern Patagonia, Chile. Front Microbiol (2016) 0.91
Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells. Transl Oncol (2009) 0.90
Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp. Mar Drugs (2014) 0.90
Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Pharmacol Biochem Behav (2007) 0.90
Novel antibacterial proteins from the microbial communities associated with the sponge Cymbastela concentrica and the green alga Ulva australis. Appl Environ Microbiol (2010) 0.90
Antileishmanial potential of a marine sponge, Haliclona exigua (Kirkpatrick) against experimental visceral leishmaniasis. Parasitol Res (2007) 0.89
Current status on marine products with reversal effect on cancer multidrug resistance. Mar Drugs (2012) 0.89
Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice. Evid Based Complement Alternat Med (2010) 0.85
Phylogenetic diversity of bacteria associated with the marine sponge Gelliodes carnosa collected from the Hainan Island coastal waters of the South China Sea. Microb Ecol (2011) 0.85
Kinase inhibitors from marine sponges. Mar Drugs (2011) 0.85
Chemically engineered extracts as an alternative source of bioactive natural product-like compounds. Proc Natl Acad Sci U S A (2006) 0.84
A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids. Tetrahedron Lett (2009) 0.84
Total synthesis of zyzzyanones A-D. Tetrahedron (2013) 0.84
Marine-derived Aspergillus species as a source of bioactive secondary metabolites. Mar Biotechnol (NY) (2013) 0.83
Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Mar Drugs (2007) 0.83
Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage. J Nat Prod (2014) 0.83
A database of natural products and chemical entities from marine habitat. Bioinformation (2007) 0.83
Marine natural products: a way to new drugs. Acta Naturae (2009) 0.82
Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom. Toxins (Basel) (2015) 0.82
Cytotoxic neviotane triterpene-type from the red sea sponge Siphonochalina siphonella. Pharmacogn Mag (2014) 0.81
In vitro and in vivo antifilarial potential of marine sponge, Haliclona exigua (Kirkpatrick), against human lymphatic filarial parasite Brugia malayi: antifilarial activity of H. exigua. Parasitol Res (2009) 0.81
Chemopreventive effects of sarcophine-diol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Mar Drugs (2009) 0.81
Integrated metagenomic and metatranscriptomic analyses of microbial communities in the meso- and bathypelagic realm of north pacific ocean. Mar Drugs (2013) 0.81
Antileishmanial activity in vitro and in vivo of constituents of sea cucumber Actinopyga lecanora. Parasitol Res (2008) 0.80
Cytotoxic and apoptosis-inducing activity of triterpene glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells. Mar Drugs (2014) 0.80
SANCDB: a South African natural compound database. J Cheminform (2015) 0.80
Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery. Mar Drugs (2014) 0.80
Terpenyl-purines from the sea. Mar Drugs (2009) 0.80
Distribution and possible function of the marine alkaloid, norzoanthamine, in the zoanthid Zoanthus sp. using MALDI imaging mass spectrometry. Mar Biotechnol (NY) (2009) 0.79
Isolation and Identification of a Flavone Apigenin from Marine Red Alga Acanthophora spicifera with Antinociceptive and Anti-Inflammatory Activities. J Exp Neurosci (2016) 0.79
Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi. Asian Pac J Trop Biomed (2011) 0.79
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity. World J Gastroenterol (2006) 0.79
Dolabelladienetriol, a compound from Dictyota pfaffii algae, inhibits the infection by Leishmania amazonensis. PLoS Negl Trop Dis (2012) 0.79
Pharmacological Potential of Phylogenetically Diverse Actinobacteria Isolated from Deep-Sea Coral Ecosystems of the Submarine Avilés Canyon in the Cantabrian Sea. Microb Ecol (2016) 0.78
Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus. J Nat Prod (2005) 0.78
Marine derived hamacanthins as lead for the development of novel PDGFRβ protein kinase inhibitors. Mar Drugs (2013) 0.78
Topsensterols A-C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp. Mar Drugs (2016) 0.77
eCAM benefits from diversity that derives from CAM. Evid Based Complement Alternat Med (2005) 0.77
Synthetic strategies to terpene quinones/hydroquinones. Mar Drugs (2012) 0.77
Development of antibiotics and the future of marine microorganisms to stem the tide of antibiotic resistance. Curr Opin Investig Drugs (2004) 0.77
High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma. Springerplus (2016) 0.77
Convergent antifouling activities of structurally distinct bioactive compounds synthesized within two sympatric Haliclona demosponges. Mar Biotechnol (NY) (2008) 0.76
Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates. Front Microbiol (2015) 0.76
Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction. Mar Drugs (2015) 0.76
Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin. Chin J Nat Med (2015) 0.76
Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum. J Nat Prod (2010) 0.76
In vitro antiplasmodial activity of bacterium RJAUTHB 14 associated with marine sponge Haliclona Grant against Plasmodium falciparum. Parasitol Res (2011) 0.76
Digestive enzymes of the crustaceans Munida and their application in cheese manufacturing: a review. Mar Drugs (2011) 0.75
Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics. Mar Drugs (2016) 0.75
A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66. Mar Drugs (2016) 0.75
Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. Molecules (2016) 0.75
Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model. Evid Based Complement Alternat Med (2015) 0.75
New distributional data on ascidian fauna (Tunicata: Ascidiacea) from Mandapam coast, Gulf of Mannar, India. Biodivers Data J (2016) 0.75
Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis. Avicenna J Phytomed (2015) 0.75
Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129. Mar Drugs (2017) 0.75
Evaluation of hepatoprotective activity of the commerson's anchovy (Stolephorus commersonnii). Indian J Pharmacol (2016) 0.75
Impact of marine drugs on cytoskeleton-mediated reproductive events. Mar Drugs (2010) 0.75
Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells. PeerJ (2017) 0.75
Deep Sea Actinomycetes and Their Secondary Metabolites. Front Microbiol (2017) 0.75
A carbohydrate approach for the formal total synthesis of (-)-aspergillide C. Beilstein J Org Chem (2014) 0.75
From Land to Sea; Embracing a Renewable Future. J Biotechnol Biomater (2014) 0.75
Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats. Mar Drugs (2017) 0.75
Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem (2017) 0.75