Published in Hypertension on January 25, 2010
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
Diabetes mellitus and vascular disease. Hypertension (2013) 1.47
Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice. Am J Physiol Endocrinol Metab (2010) 1.17
The renin angiotensin aldosterone system and insulin resistance in humans. Curr Hypertens Rep (2013) 1.04
Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology (2013) 1.01
Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Arch (2012) 0.99
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. PLoS One (2012) 0.92
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab (2013) 0.90
Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS One (2013) 0.88
Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. J Am Heart Assoc (2014) 0.87
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes. Cardiovasc Diabetol (2013) 0.87
Chronic blockade of angiotensin AT₁ receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats. Br J Pharmacol (2014) 0.87
Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One (2012) 0.85
12- and 15-lipoxygenases in adipose tissue inflammation. Prostaglandins Other Lipid Mediat (2012) 0.83
Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat. Metabolism (2011) 0.83
Weight loss and hypophagia after high-dose AT1-blockade is only observed after high dosing and depends on regular leptin signalling but not blood pressure. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.80
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function. Diabetes (2015) 0.79
The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus. Curr Cardiol Rep (2010) 0.77
Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis. Korean J Physiol Pharmacol (2015) 0.77
Role of renin-angiotensin system blockades in reciprocal relationship between insulin resistance and endothelial dysfunction. Hypertension (2010) 0.77
STAT4 contributes to adipose tissue inflammation and atherosclerosis. J Endocrinol (2015) 0.76
The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats. Br J Pharmacol (2016) 0.76
High-fat diet-induced glucose dysregulation is independent of changes in Islet ACE2 in mice. Am J Physiol Regul Integr Comp Physiol (2016) 0.75
Functional role of sodium glucose transporter in high glucose-mediated angiotensin type 1 receptor downregulation in human proximal tubule cells. Am J Physiol Renal Physiol (2012) 0.75
Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation. Mediators Inflamm (2017) 0.75
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med (2001) 3.14
Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab (2008) 3.11
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials. J Am Coll Cardiol (2005) 2.81
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem (2008) 2.72
Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis. Hypertension (2006) 1.74
Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors. Diabetes (2002) 1.70
The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol (2003) 1.65
Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension (2003) 1.62
Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol (2004) 1.61
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol Endocrinol Metab (2008) 1.52
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
From mitochondria to disease: role of the renin-angiotensin system. Am J Nephrol (2007) 1.41
Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes (2006) 1.37
Angiotensin II and the development of insulin resistance: implications for diabetes. Mol Cell Endocrinol (2008) 1.33
Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J Clin Endocrinol Metab (2003) 1.25
The physiology of a local renin-angiotensin system in the pancreas. J Physiol (2007) 1.23
Is angiotensin-II an endogenous pro-inflammatory molecule? Med Sci Monit (2005) 1.23
Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species. Am J Physiol Heart Circ Physiol (2008) 1.19
Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: reversal by angiotensin II type 1 receptor blockade. Circulation (2005) 1.17
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. Biochem Biophys Res Commun (2005) 1.12
Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice. Antioxid Redox Signal (2007) 1.03
Effects of telmisartan on fat distribution in individuals with the metabolic syndrome. J Hypertens (2007) 1.01
Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models. Am J Hypertens (2008) 0.98
Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int (1999) 0.94
Angiotensin II receptor blockers downsize adipocytes in spontaneously type 2 diabetic rats with visceral fat obesity. Am J Hypertens (2007) 0.91
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice. Am J Pathol (2005) 0.91
Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. Nephrol Dial Transplant (2008) 0.90
Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytes. Am J Physiol Endocrinol Metab (2006) 0.89
Effects of angiotensin II type 1 receptor blockade on beta-cell function in humans. Diabetes Care (2007) 0.88
Vasoactive drugs enhance pancreatic islet blood flow, augment insulin secretion and improve glucose tolerance in female rats. Clin Sci (Lond) (2007) 0.87
Angiotensinogen, angiotensin II and adipose tissue development. Int J Obes Relat Metab Disord (2000) 0.87
ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages. Arch Med Res (2007) 0.86
Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors. Am J Physiol Regul Integr Comp Physiol (2008) 0.85
Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance. Metabolism (2008) 0.84
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res (2011) 2.38
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol Cell Biol (2007) 2.32
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A (2007) 2.02
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes (2007) 1.96
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition. Diabetes (2007) 1.85
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol (2009) 1.74
A practical guide to rodent islet isolation and assessment. Biol Proced Online (2009) 1.74
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation. Exp Neurol (2011) 1.65
Effects of lifestyle intervention on health care costs: Improving Control with Activity and Nutrition (ICAN). J Am Diet Assoc (2007) 1.62
Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol (2004) 1.61
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arterioscler Thromb Vasc Biol (2011) 1.54
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev (2002) 1.52
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol Endocrinol Metab (2008) 1.52
12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem (2003) 1.50
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia (2014) 1.49
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes (2008) 1.48
Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages. Endocrinology (2006) 1.47
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
Intrarenal ghrelin receptors regulate ENaC-dependent sodium reabsorption by a cAMP-dependent pathway. Kidney Int (2013) 1.44
IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science (2009) 1.43
Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes (2012) 1.37
Inflammatory mechanisms of diabetic complications. Curr Diab Rep (2007) 1.32
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc Natl Acad Sci U S A (2012) 1.28
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab (2008) 1.28
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol (2010) 1.28
Impact of lifestyle intervention on lost productivity and disability: improving control with activity and nutrition. J Occup Environ Med (2009) 1.26
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages. Endocrinology (2006) 1.26
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. Am J Physiol Heart Circ Physiol (2008) 1.25
Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets. Endocrinology (2008) 1.20
Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism. Hypertension (2006) 1.20
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab (2010) 1.20
Mechanisms underlying episodic gonadotropin-releasing hormone secretion. Front Neuroendocrinol (2003) 1.19
Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis. Cardiology (2015) 1.19
Autoimmune diabetes is blocked in Stat4-deficient mice. J Autoimmun (2004) 1.16
Dose-dependent switch in response of gonadotropin-releasing hormone (GnRH) neurons to GnRH mediated through the type I GnRH receptor. Endocrinology (2003) 1.15
Prenatal androgen exposure programs metabolic dysfunction in female mice. J Endocrinol (2010) 1.13
Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol (2012) 1.10
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun (2006) 1.08
Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proc Natl Acad Sci U S A (2012) 1.08
Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis. Am J Physiol Endocrinol Metab (2012) 1.08
Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium (2010) 1.07
Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells. Am J Physiol Renal Physiol (2002) 1.07
Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care (2005) 1.07
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes (2006) 1.05
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury. Crit Care (2012) 1.05
Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem Biophys Res Commun (2002) 1.05
The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin. Circ Res (2008) 1.04
Lipoxygenases and lipid signaling in vascular cells in diabetes. Front Biosci (2003) 1.03
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem (2011) 1.03
Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats. Hypertension (2008) 1.03
Islet inflammation: a unifying target for diabetes treatment? Trends Endocrinol Metab (2013) 1.02
Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology (2013) 1.01
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Am J Physiol Endocrinol Metab (2005) 1.00
Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets. PLoS One (2009) 0.98
The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation. Transplantation (2004) 0.98
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem (2014) 0.97
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab (2012) 0.97
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Am J Pathol (2010) 0.97
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand. J Biol Chem (2014) 0.96
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol (2009) 0.96
Suppression of autoimmune diabetes by viral IL-10 gene transfer. J Immunol (2002) 0.96
Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles. Mol Biol Cell (2010) 0.95
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. Mediators Inflamm (2012) 0.95
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab (2012) 0.95
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95
The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas (2003) 0.95
Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun (2010) 0.94
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem (2009) 0.94