Published in Trends Endocrinol Metab on February 26, 2013
Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes. Diabetologia (2014) 1.59
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab (2013) 0.90
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. J Clin Endocrinol Metab (2014) 0.89
Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment. J Lipid Res (2016) 0.87
Potential roles of GPR120 and its agonists in the management of diabetes. Drug Des Devel Ther (2014) 0.84
G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov (2016) 0.83
Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ. J Biol Chem (2015) 0.81
Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Sci Rep (2015) 0.80
TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.80
Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets. Cell Calcium (2015) 0.79
Molecular and genetic inflammation networks in major human diseases. Mol Biosyst (2016) 0.79
The expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes. PLoS One (2013) 0.79
Lipids and immunoinflammatory pathways of beta cell destruction. Diabetologia (2016) 0.78
Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 Diabetes. J Diabetes Res (2016) 0.77
Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes. Mol Endocrinol (2015) 0.77
Aspirin, diabetes, and amyloid: re-examination of the inhibition of amyloid formation by aspirin and ketoprofen. ACS Chem Biol (2014) 0.76
12-lipoxygenase inhibitor improves functions of cytokine-treated human islets and type 2 diabetic islets J Clin Endocrinol Metab (2017) 0.76
The Impact of Cell Surface PEGylation and Short-Course Immunotherapy on Islet Graft Survival in an Allogeneic Murine Model. Acta Biomater (2016) 0.75
Assessment of the link between in utero exposure to 2-aminoanthracene (2AA) and type-1 diabetes (T1D). J Diabetes Metab Disord (2017) 0.75
Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes (2014) 0.75
Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med (2007) 11.62
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Type 2 diabetes as an inflammatory disease. Nat Rev Immunol (2011) 8.30
Functional interactions between the gut microbiota and host metabolism. Nature (2012) 7.91
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes (2005) 5.54
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J (2011) 3.93
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med (2010) 3.56
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev (2013) 2.65
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab (2012) 2.46
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes (2011) 2.29
β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care (2012) 2.20
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes (2008) 2.00
Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest (2007) 1.99
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci U S A (2009) 1.97
Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes. Cytokine (2011) 1.91
As a matter of fat. Cell Metab (2009) 1.85
Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes (2010) 1.80
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab (2012) 1.77
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One (2010) 1.68
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. Diabetes (2009) 1.60
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab (2009) 1.55
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes (2011) 1.52
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. Endocrinology (2012) 1.49
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia (2010) 1.48
Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes. J Clin Invest (2011) 1.47
Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab (2010) 1.46
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care (2012) 1.46
IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. Diabetes (2004) 1.44
Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis. Diabetologia (2008) 1.41
ER stress-induced inflammation: does it aid or impede disease progression? Trends Mol Med (2012) 1.41
Effect of rituximab on human in vivo antibody immune responses. J Allergy Clin Immunol (2011) 1.39
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes (2008) 1.31
12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets. J Clin Endocrinol Metab (2010) 1.31
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes (2013) 1.30
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem (2010) 1.27
Leptin: linking obesity, the metabolic syndrome, and cardiovascular disease. Curr Hypertens Rep (2008) 1.22
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem (2011) 1.20
Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice. Am J Physiol Endocrinol Metab (2010) 1.17
The role of adipokines in β-cell failure of type 2 diabetes. J Endocrinol (2013) 1.15
Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia (2012) 1.13
High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition. Diabetes (2011) 1.11
Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes. Pediatr Diabetes (2011) 1.11
Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci (2011) 1.11
Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function. Int J Clin Pract (2008) 1.10
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol (2012) 1.10
Expression and regulation of chemokines in murine and human type 1 diabetes. Diabetes (2011) 1.10
PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. Mol Endocrinol (2012) 1.10
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells. Proc Natl Acad Sci U S A (2012) 1.09
TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes. J Immunol (2010) 1.09
Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium (2010) 1.07
Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes. Diabetes (2012) 1.05
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J Autoimmun (2011) 1.04
Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease. Diabetologia (2012) 1.04
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Diabetologia (2011) 1.04
IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes. J Immunol (2011) 1.03
Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? Diabetes Res Clin Pract (2011) 1.02
Inhibition of autoimmune diabetes by TLR2 tolerance. J Immunol (2011) 1.01
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia (2012) 1.01
Identification of autoantibody-negative autoimmune type 2 diabetic patients. Diabetes Care (2010) 1.00
Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation. Clin Exp Immunol (2012) 1.00
Association between childhood obesity and subsequent Type 1 diabetes: a systematic review and meta-analysis. Diabet Med (2011) 1.00
cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets. Diabetologia (2011) 0.99
Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial. Diabetes Care (2011) 0.97
Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling. PLoS One (2012) 0.97
'Sensing' the link between type 1 and type 2 diabetes. Diabetes Metab Res Rev (2011) 0.96
Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. Diabetes (2010) 0.95
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Cell Metab (2012) 0.95
Production and function of IL-12 in islets and beta cells. Diabetologia (2012) 0.94
Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains. Int J Exp Pathol (2010) 0.93
The evil axis of obesity, inflammation and type-2 diabetes. Endocr Metab Immune Disord Drug Targets (2011) 0.91
Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin. Peptides (2010) 0.90
Metabolic stress, IAPP and islet amyloid. Diabetes Obes Metab (2012) 0.90
Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms. Diabetes Obes Metab (2012) 0.90
Biomarkers and immune-modulating therapies for type 2 diabetes. Trends Immunol (2012) 0.89
Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. PLoS One (2012) 0.87
Tc17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse model. J Immunol (2012) 0.84
New and future immunomodulatory therapy in type 1 diabetes. Trends Mol Med (2012) 0.83
Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice. Eur J Immunol (2011) 0.83
TNF-α acutely upregulates amylin expression in murine pancreatic beta cells. Diabetologia (2010) 0.82
Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis. Arch Biochem Biophys (2012) 0.82
Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline. J Diabetes Mellitus (2012) 0.82
Oxidative stress and beta cell dysfunction. Methods Mol Biol (2012) 0.81
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol (2011) 0.80
Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes. J Immunol (2012) 0.79
Adiponectin downregulates hyperglycemia and reduces pancreatic islet apoptosis after roux-en-y gastric bypass surgery. Obes Surg (2011) 0.76
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity (2005) 6.71
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest (2006) 2.76
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes (2007) 1.96
The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med (2006) 1.96
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition. Diabetes (2007) 1.85
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem (2005) 1.84
Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. Circ Res (2006) 1.81
Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice. Hypertension (2010) 1.74
Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res (2010) 1.72
The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood (2003) 1.70
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation. Exp Neurol (2011) 1.65
Effects of lifestyle intervention on health care costs: Improving Control with Activity and Nutrition (ICAN). J Am Diet Assoc (2007) 1.62
Lipid inflammatory mediators in diabetic vascular disease. Arterioscler Thromb Vasc Biol (2004) 1.61
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol Endocrinol Metab (2008) 1.52
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest (2004) 1.50
12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem (2003) 1.50
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia (2014) 1.49
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes (2008) 1.48
Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages. Endocrinology (2006) 1.47
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Am J Physiol Lung Cell Mol Physiol (2006) 1.41
Inflammatory mechanisms of diabetic complications. Curr Diab Rep (2007) 1.32
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab (2008) 1.28
Impact of lifestyle intervention on lost productivity and disability: improving control with activity and nutrition. J Occup Environ Med (2009) 1.26
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages. Endocrinology (2006) 1.26
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. Am J Physiol Heart Circ Physiol (2008) 1.25
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab (2010) 1.20
Autoimmune diabetes is blocked in Stat4-deficient mice. J Autoimmun (2004) 1.16
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. J Exp Med (2006) 1.12
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol (2012) 1.10
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun (2006) 1.08
Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells. Am J Physiol Renal Physiol (2002) 1.07
Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care (2005) 1.07
Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem Biophys Res Commun (2002) 1.05
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes (2006) 1.05
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury. Crit Care (2012) 1.05
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem (2011) 1.03
Lipoxygenases and lipid signaling in vascular cells in diabetes. Front Biosci (2003) 1.03
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Am J Physiol Endocrinol Metab (2005) 1.00
Adaptation of resistance arteries to increases in pressure. Microcirculation (2002) 0.99
The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation. Transplantation (2004) 0.98
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Am J Pathol (2010) 0.97
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol (2009) 0.96
Suppression of autoimmune diabetes by viral IL-10 gene transfer. J Immunol (2002) 0.96
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. Mediators Inflamm (2012) 0.95
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab (2012) 0.95
The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas (2003) 0.95
Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun (2010) 0.94
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem (2009) 0.94
The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice. Clin Immunol (2003) 0.93
On-tissue identification of insulin: in situ reduction coupled with mass spectrometry imaging. Proteomics Clin Appl (2011) 0.93
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies. Free Radic Biol Med (2010) 0.93
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes. Ann N Y Acad Sci (2003) 0.92
Mechanisms by which diabetes increases cardiovascular disease. Drug Discov Today Dis Mech (2007) 0.91
Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol (2011) 0.91
Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant (2005) 0.90
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. Arterioscler Thromb Vasc Biol (2008) 0.90
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem (2014) 0.89
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. J Clin Endocrinol Metab (2014) 0.89
Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. Obesity (Silver Spring) (2014) 0.89
Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism. Endocrinology (2002) 0.89
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One (2013) 0.88
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes. J Clin Endocrinol Metab (2014) 0.88
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. Biochem Pharmacol (2012) 0.88
Insulin and glucose play a role in foam cell formation and function. Cardiovasc Diabetol (2006) 0.87
Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability. Biochem Biophys Res Commun (2003) 0.86
Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid. Mol Endocrinol (2002) 0.86
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol (2010) 0.86
Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes. Bioorg Med Chem Lett (2006) 0.84
Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries. Hypertension (2002) 0.83
Elevated glucose activates protein synthesis in cultured cardiac myocytes. Metabolism (2005) 0.83
12- and 15-lipoxygenases in adipose tissue inflammation. Prostaglandins Other Lipid Mediat (2012) 0.83
Lifestyle intervention in obese patients with type 2 diabetes: impact of the patient's educational background. Obesity (Silver Spring) (2006) 0.82
12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells. Endocrinology (2003) 0.82
Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. Endocrine (2002) 0.81
Lisofylline: a potential lead for the treatment of diabetes. Biochem Pharmacol (2005) 0.81
Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. Autoimmunity (2010) 0.81
The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth. Arterioscler Thromb Vasc Biol (2005) 0.80
Development of a coculture system and use of confocal laser fluorescent microscopy to study human microvascular endothelial cell and mural cell interaction. Microvasc Res (2005) 0.80
Role of inflammatory pathways in the development and cardiovascular complications of type 2 diabetes. Curr Diab Rep (2002) 0.80
Viral IL-10-mediated immune regulation in pancreatic islet transplantation. Mol Ther (2005) 0.79
Role of RIHP and renal tubular sodium transporters in volume retention of pregnant rats. Am J Hypertens (2005) 0.78
Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats. Am J Physiol Renal Physiol (2002) 0.78
Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats. Metabolism (2004) 0.77
Different natriuretic responses in obese and lean rats in response to nitric oxide reduction. Am J Hypertens (2011) 0.76
12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy. J Diabetes Mellitus (2013) 0.76
Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition. Endocrinology (2003) 0.76
A new dietary approach to reduce the risk of type 2 diabetes? Diabetes Care (2004) 0.75