Published in Oncogene on January 25, 2010
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol (2013) 1.95
Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population. J Natl Cancer Inst (2012) 1.40
Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer. Gynecol Oncol (2011) 1.32
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med (2013) 1.23
Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. Oncogene (2013) 1.23
Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J (2012) 1.10
Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix. Clin Epigenetics (2012) 1.06
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Res (2013) 1.02
Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis (2013) 0.92
Epigenetic mechanisms in virus-induced tumorigenesis. Clin Epigenetics (2011) 0.88
Integrated virus-host methylome analysis in head and neck squamous cell carcinoma. Epigenetics (2013) 0.84
Analysis of host genetic diversity and viral entry as sources of between-host variation in viral load. Virus Res (2012) 0.83
History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia. Epigenetics (2011) 0.83
Characterization of HPV DNA methylation of contiguous CpG sites by bisulfite treatment and massively parallel sequencing-the FRAGMENT approach. Front Genet (2014) 0.82
Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer. Clin Cancer Res (2014) 0.81
Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression. PLoS One (2012) 0.81
Methylation of human papillomavirus Type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR. J Clin Microbiol (2013) 0.80
O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes. Oncotarget (2016) 0.76
Effectiveness of Toki's criteria and determination of variables for identification of HPV L1 protein in oral lesions. Med Oral Patol Oral Cir Bucal (2014) 0.75
Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma. Mol Ther Oncolytics (2015) 0.75
Association of atopic diseases and parvovirus B19 with acute lymphoblastic leukemia in childhood and adolescence in the northeast of Brazil. Int J Clin Oncol (2016) 0.75
Epigenetic Alterations in Human Papillomavirus-Associated Cancers. Viruses (2017) 0.75
Gene-expression profiles in hereditary breast cancer. N Engl J Med (2001) 29.80
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature (2001) 4.99
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res (1997) 4.73
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet (2001) 3.96
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene (2006) 2.69
Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene (2011) 2.42
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J Natl Cancer Inst (1999) 2.34
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res (2001) 2.10
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res (1999) 2.09
Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res (2000) 1.91
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008) 1.78
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene (2011) 1.76
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. Cancer Res (1999) 1.69
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene (2010) 1.65
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin Cancer Res (2001) 1.63
Late Crohn's disease patients present an increase in peripheral Th17 cells and cytokine production compared with early patients. Aliment Pharmacol Ther (2009) 1.62
The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors. Clin Cancer Res (2013) 1.47
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene (1998) 1.36
Epigenetic regulation of telomeres in human cancer. Oncogene (2008) 1.33
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer. Oncogene (2011) 1.31
Proteins that bind methylated DNA and human cancer: reading the wrong words. Br J Cancer (2008) 1.27
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding. Carcinogenesis (2006) 1.25
NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Cancer Prev Res (Phila) (2011) 1.21
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene (2001) 1.17
The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene. Nucleic Acids Res (2009) 1.16
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene (2011) 1.13
Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays. Br J Cancer (2007) 1.12
Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta. Oncogene (2006) 1.11
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1). J Pathol (2006) 1.10
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res (2000) 1.10
Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins. Oncogene (2008) 1.07
5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut (2000) 1.04
Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. Cancer Res (2001) 0.98
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. Clin Cancer Res (1999) 0.97
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. Oncogene (2009) 0.97
Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene (2008) 0.93
Genetic and epigenetic profile of sporadic pheochromocytomas. J Med Genet (2004) 0.90
Epigenetic control of nuclear architecture. Cell Mol Life Sci (2007) 0.90
Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events. J Cell Physiol (2007) 0.89
Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas. Oncogene (2008) 0.88
Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents. P R Health Sci J (2009) 0.87
DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes. Oncogene (2013) 0.86
Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms. Leukemia (2005) 0.85
Merkel cell carcinoma of the vulva. Gynecol Oncol (1997) 0.83
Aberrant epigenetic landscape in intellectual disability. Prog Brain Res (2012) 0.81
Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. Oncogene (2009) 0.78
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene (2016) 0.78
Towards defining the lymphoma methylome. Leukemia (2006) 0.78
Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas. Carcinogenesis (2005) 0.76
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer. Genes Chromosomes Cancer (2001) 0.76
[Introduction to molecular biology of endometrial cancer]. Med Clin (Barc) (1996) 0.75
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene (2017) 0.75