PubRank

Jonathan Whittaker

Author PubWeight™ 28.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 2002 2.73
2 How insulin engages its primary binding site on the insulin receptor. Nature 2013 2.52
3 Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A 2010 1.36
4 A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum. Am J Physiol Endocrinol Metab 2003 1.30
5 Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. J Biol Chem 2009 1.16
6 How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol 2004 1.15
7 Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. Biochemistry 2004 1.07
8 Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir. J Diabetes Sci Technol 2012 1.07
9 High-affinity insulin binding: insulin interacts with two receptor ligand binding sites. Biochemistry 2008 1.07
10 Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem 2009 1.02
11 Precise mapping of an IGF-I-binding site on the IGF-1R. Biochem J 2007 0.94
12 The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice. J Biol Chem 2007 0.93
13 An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design. J Biol Chem 2010 0.91
14 Insulin receptor tyrosine kinase activity and phosphorylation of tyrosines 1162 and 1163 are required for insulin-increased prolactin gene expression. Mol Cell Endocrinol 2002 0.89
15 Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis. FEBS Lett 2004 0.88
16 The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J Biol Chem 2008 0.87
17 Characterization of a second ligand binding site of the insulin receptor. Biochem Biophys Res Commun 2006 0.86
18 Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family. J Biol Chem 2009 0.85
19 Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins. Biochemistry 2009 0.84
20 Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J Biol Chem 2010 0.82
21 A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II. J Biol Chem 2009 0.82
22 Comparative properties of insulin-like growth factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 prepared by total chemical synthesis. Angew Chem Int Ed Engl 2008 0.82
23 Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J Biol Chem 2009 0.81
24 Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormone. J Biol Chem 2010 0.79
25 Rescue of ligand binding of a mutant IGF-I receptor by complementation. Biochem Biophys Res Commun 2005 0.79
26 Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin. Angew Chem Int Ed Engl 2010 0.79
27 Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins. Protein Expr Purif 2002 0.76