|
1
|
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.
|
J Biol Chem
|
2005
|
2.57
|
|
2
|
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
|
J Neurosci
|
2004
|
1.89
|
|
3
|
Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.
|
Exp Neurol
|
2008
|
1.54
|
|
4
|
Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis.
|
Biochem Biophys Res Commun
|
2010
|
1.50
|
|
5
|
5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.
|
J Immunol
|
2005
|
1.49
|
|
6
|
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model.
|
Nutr Metab (Lond)
|
2006
|
1.49
|
|
7
|
Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact.
|
J Neuroinflammation
|
2009
|
1.42
|
|
8
|
N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain.
|
J Neurosci Res
|
2004
|
1.38
|
|
9
|
Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke.
|
J Neurosci Res
|
2004
|
1.29
|
|
10
|
S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke.
|
J Cereb Blood Flow Metab
|
2005
|
1.28
|
|
11
|
T-bet is essential for the progression of experimental autoimmune encephalomyelitis.
|
Immunology
|
2006
|
1.25
|
|
12
|
The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma.
|
J Immunol
|
2004
|
1.24
|
|
13
|
Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke.
|
Nitric Oxide
|
2006
|
1.22
|
|
14
|
Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy.
|
J Immunol
|
2004
|
1.22
|
|
15
|
GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions.
|
Glia
|
2007
|
1.14
|
|
16
|
Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line.
|
J Neurochem
|
2003
|
1.11
|
|
17
|
HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis.
|
FASEB J
|
2005
|
1.11
|
|
18
|
Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury.
|
J Neurochem
|
2007
|
1.11
|
|
19
|
Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats.
|
J Neurosci Res
|
2005
|
1.09
|
|
20
|
Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine.
|
Exp Neurol
|
2007
|
1.08
|
|
21
|
IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases.
|
J Immunol
|
2006
|
1.06
|
|
22
|
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.
|
J Neurosci Res
|
2006
|
1.06
|
|
23
|
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease.
|
J Neurochem
|
2008
|
1.05
|
|
24
|
Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats.
|
Pediatr Res
|
2006
|
1.04
|
|
25
|
Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.
|
Am J Pathol
|
2006
|
1.03
|
|
26
|
N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia.
|
Brain Res
|
2003
|
1.03
|
|
27
|
Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia.
|
J Neurochem
|
2007
|
1.03
|
|
28
|
Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease.
|
J Neurosci Res
|
2005
|
1.02
|
|
29
|
Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine.
|
Neurosci Lett
|
2002
|
1.02
|
|
30
|
Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease.
|
FASEB J
|
2002
|
1.02
|
|
31
|
Dysfunction of peroxisomes in twitcher mice brain: a possible mechanism of psychosine-induced disease.
|
Biochem Biophys Res Commun
|
2006
|
1.01
|
|
32
|
Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin.
|
Neurosci Lett
|
2002
|
0.99
|
|
33
|
Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.
|
J Neuroinflammation
|
2006
|
0.99
|
|
34
|
Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.
|
J Neurochem
|
2008
|
0.99
|
|
35
|
Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E.
|
Free Radic Biol Med
|
2004
|
0.99
|
|
36
|
A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases.
|
J Neurosci
|
2004
|
0.98
|
|
37
|
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
|
J Neurochem
|
2012
|
0.98
|
|
38
|
Synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis.
|
J Neurochem
|
2011
|
0.97
|
|
39
|
Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.
|
Glia
|
2010
|
0.96
|
|
40
|
S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.
|
J Neuroinflammation
|
2011
|
0.95
|
|
41
|
Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat.
|
J Neuroinflammation
|
2009
|
0.94
|
|
42
|
The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein.
|
J Neurosci
|
2003
|
0.94
|
|
43
|
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia.
|
J Neuroinflammation
|
2005
|
0.93
|
|
44
|
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.
|
Neurosci Lett
|
2008
|
0.93
|
|
45
|
Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.
|
Brain Res
|
2004
|
0.93
|
|
46
|
Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction.
|
J Neurochem
|
2005
|
0.92
|
|
47
|
Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures.
|
J Neurochem
|
2008
|
0.92
|
|
48
|
N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats.
|
J Autoimmune Dis
|
2005
|
0.92
|
|
49
|
Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.
|
Glia
|
2009
|
0.92
|
|
50
|
Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability.
|
Free Radic Biol Med
|
2004
|
0.89
|
|
51
|
Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair.
|
Future Neurol
|
2008
|
0.88
|
|
52
|
The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase.
|
J Neurochem
|
2004
|
0.88
|
|
53
|
Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha.
|
Free Radic Biol Med
|
2003
|
0.88
|
|
54
|
Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy.
|
J Nephrol
|
2003
|
0.87
|
|
55
|
Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion.
|
Restor Neurol Neurosci
|
2012
|
0.86
|
|
56
|
A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma.
|
J Biol Chem
|
2005
|
0.85
|
|
57
|
STAT3 regulation by S-nitrosylation: implication for inflammatory disease.
|
Antioxid Redox Signal
|
2014
|
0.85
|
|
58
|
S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions.
|
J Biol Chem
|
2012
|
0.85
|
|
59
|
Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease.
|
Brain Res
|
2013
|
0.84
|
|
60
|
Lactosylceramide: a lipid second messenger in neuroinflammatory disease.
|
J Neurochem
|
2007
|
0.83
|
|
61
|
Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathology.
|
J Child Neurol
|
2009
|
0.82
|
|
62
|
Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney.
|
Mol Cell Biochem
|
2002
|
0.82
|
|
63
|
Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells.
|
Glia
|
2005
|
0.82
|
|
64
|
Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion.
|
J Alzheimers Dis
|
2013
|
0.81
|
|
65
|
Attenuation of lipopolysaccharide-induced inflammatory response and phospholipids metabolism at the feto-maternal interface by N-acetyl cysteine.
|
Pediatr Res
|
2008
|
0.81
|
|
66
|
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.
|
Am J Pathol
|
2012
|
0.81
|
|
67
|
AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model.
|
Am J Pathol
|
2013
|
0.78
|
|
68
|
15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases.
|
J Inflamm (Lond)
|
2008
|
0.77
|
|
69
|
Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells.
|
Neuropharmacology
|
2005
|
0.77
|
|
70
|
Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease.
|
J Neurosci Res
|
2014
|
0.76
|
|
71
|
PPARα activation induces N(ε)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1.
|
Lipids
|
2013
|
0.75
|
|
72
|
Cytogenetic remission with imatinib therapy in hypereosinophilic syndrome with trisomy 8 and resolution of severe cardiac dysfunction.
|
Leuk Lymphoma
|
2005
|
0.75
|