Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair.

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Published in Future Neurol on March 01, 2008

Authors

Silva Markovic-Plese1, Avtar K Singh, Inderjit Singh

Author Affiliations

1: University of North Carolina at Chapel Hill, Department of Neurology, Department of Microbiology & Immunology, Chapel Hill, NC, USA, Tel.: +1 919 966 3701;

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Rho GTPases in cell biology. Nature (2002) 22.81

Axonal transection in the lesions of multiple sclerosis. N Engl J Med (1998) 12.21

Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet (1998) 11.69

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Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol (2000) 9.73

Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA (1999) 9.18

Immunology of multiple sclerosis. Annu Rev Immunol (2005) 9.08

Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology (1995) 8.63

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology (1993) 8.21

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med (2007) 6.19

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature (2002) 5.24

Statins as a newly recognized type of immunomodulator. Nat Med (2000) 5.00

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler (1999) 4.91

Statins do more than just lower cholesterol. Lancet (1996) 4.39

Cholesterol, lipid rafts, and disease. J Clin Invest (2002) 4.05

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med (2000) 3.98

Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet (2004) 3.95

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Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med (2002) 3.68

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol (2001) 3.65

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Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev Immunol (2006) 2.70

Multiple sclerosis. J Clin Invest (2004) 2.48

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol (2003) 2.37

Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci (1998) 2.36

Statins as immunomodulators: comparison with interferon-beta 1b in MS. Neurology (2002) 2.34

The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest (2002) 2.30

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Autoimmune inflammation from the Th17 perspective. Autoimmun Rev (2006) 2.04

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Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med (2006) 1.69

Multiple sclerosis: remyelination of nascent lesions. Ann Neurol (1993) 1.64

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