PubRank

Kari Alitalo

Author PubWeight™ 392.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003 12.96
2 Copy number variation and selection during reprogramming to pluripotency. Nature 2011 8.24
3 Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007 7.75
4 Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 2003 7.42
5 Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 2007 6.44
6 Lymphangiogenesis: Molecular mechanisms and future promise. Cell 2010 5.84
7 Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009 5.55
8 Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008 5.15
9 Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 2002 4.66
10 Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest 2005 4.09
11 Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 2009 4.07
12 Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 2002 3.99
13 Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2002 3.90
14 Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002 3.44
15 Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 2004 3.38
16 Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med 2004 3.32
17 PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 2005 3.29
18 VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009 3.28
19 Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A 2008 3.27
20 The biology of vascular endothelial growth factors. Cardiovasc Res 2005 3.22
21 Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol 2002 2.99
22 Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 2004 2.95
23 Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 2008 2.85
24 Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 2002 2.68
25 VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2006 2.66
26 VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood 2002 2.52
27 Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 2008 2.49
28 Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005 2.48
29 Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 2011 2.47
30 VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med 2011 2.38
31 Signaling and functions of angiopoietin-1 in vascular protection. Circ Res 2006 2.34
32 Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 2009 2.30
33 Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci U S A 2002 2.30
34 Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med 2007 2.29
35 VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ Res 2003 2.25
36 FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol 2009 2.17
37 Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res 2008 2.15
38 Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 2004 2.13
39 Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors. Genes Chromosomes Cancer 2010 2.11
40 VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol 2011 2.09
41 Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood 2010 2.04
42 Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev 2005 2.01
43 Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest 2013 1.92
44 The lymphatic vasculature: recent progress and paradigms. Annu Rev Cell Dev Biol 2005 1.91
45 Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest 2011 1.88
46 Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol 2008 1.88
47 Biological basis of therapeutic lymphangiogenesis. Circulation 2011 1.85
48 Vascular growth factors and lymphangiogenesis. Physiol Rev 2002 1.85
49 Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 2003 1.85
50 Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell 2008 1.82
51 Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci 2002 1.82
52 Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood 2011 1.82
53 VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer 2002 1.80
54 Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J 2006 1.79
55 Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc Natl Acad Sci U S A 2003 1.79
56 Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood 2005 1.75
57 Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability. Circ Res 2004 1.74
58 Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res 2005 1.73
59 Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer Res 2007 1.73
60 CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 2011 1.72
61 Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol 2010 1.72
62 Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood 2005 1.71
63 Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med 2010 1.69
64 Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell 2012 1.69
65 Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J 2006 1.69
66 Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis. Circulation 2003 1.67
67 Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J 2002 1.67
68 Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies. Circ Res 2003 1.64
69 An important role of lymphatic vessel activation in limiting acute inflammation. Blood 2011 1.62
70 Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. FASEB J 2002 1.62
71 Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proc Natl Acad Sci U S A 2010 1.60
72 Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice. Circulation 2005 1.59
73 A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J 2013 1.58
74 Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 2004 1.57
75 Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms. Circulation 2009 1.57
76 Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol 2005 1.57
77 Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods 2008 1.55
78 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 2003 1.53
79 Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA. J Immunol Methods 2004 1.53
80 Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation 2005 1.52
81 Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development 2009 1.51
82 Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro. Physiol Genomics 2007 1.51
83 Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol 2010 1.51
84 Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol 2013 1.50
85 Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein. Circ Res 2007 1.48
86 Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice. Cancer Res 2007 1.48
87 Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis. PLoS Pathog 2007 1.48
88 Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 2012 1.47
89 Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 2008 1.47
90 Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 2002 1.47
91 VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci 2006 1.46
92 Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. J Biol Chem 2003 1.46
93 Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest 2006 1.46
94 VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron 2011 1.45
95 Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med 2007 1.43
96 Molecular lymphangiogenesis: new players. Trends Cell Biol 2005 1.42
97 The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. FASEB J 2002 1.42
98 Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. Am J Pathol 2006 1.39
99 Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. FASEB J 2003 1.38
100 Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues. Am J Pathol 2008 1.38
101 Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res 2008 1.38
102 VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 2010 1.37
103 Lymphatic endothelium: a new frontier of metastasis research. Nat Cell Biol 2002 1.36
104 Role of lymphangiogenic factors in tumor metastasis. Biochim Biophys Acta 2004 1.35
105 Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes Dev 2011 1.35
106 Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. J Exp Med 2003 1.35
107 Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors. J Gene Med 2004 1.35
108 Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell 2010 1.32
109 Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation 2010 1.31
110 Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer. Cancer Res 2008 1.30
111 Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 2006 1.30
112 Modulating metastasis by a lymphangiogenic switch in prostate cancer. Int J Cancer 2007 1.30
113 PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood 2004 1.30
114 Lymphangiogenic gene therapy with minimal blood vascular side effects. J Exp Med 2002 1.29
115 The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res 2008 1.28
116 Lymphangiogenic growth factors, receptors and therapies. Thromb Haemost 2003 1.27
117 Lymphangiogenic factors, mechanisms, and applications. J Clin Invest 2014 1.27
118 Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey. Invest Ophthalmol Vis Sci 2002 1.26
119 Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res 2002 1.25
120 CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res 2010 1.24
121 Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. FASEB J 2007 1.24
122 The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest 2014 1.23
123 A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 2013 1.22
124 Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO Rep 2004 1.21
125 Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J 2003 1.20
126 Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts. Circulation 2010 1.20
127 Angiogenic responses of vascular endothelial growth factors in periadventitial tissue. Hum Gene Ther 2003 1.19
128 Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity. J Biol Chem 2003 1.19
129 In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proc Natl Acad Sci U S A 2012 1.19
130 Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. Am J Pathol 2010 1.18
131 Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer. FASEB J 2005 1.16
132 VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res 2007 1.16
133 Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. Am J Pathol 2007 1.16
134 Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. J Rheumatol 2002 1.16
135 Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. J Immunol 2012 1.15
136 Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res 2009 1.14
137 Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn 2009 1.14
138 Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol 2008 1.13
139 How do angiopoietins Tie in with vascular endothelial growth factors? Curr Opin Hematol 2010 1.13
140 KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe 2011 1.11
141 Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis. Circulation 2002 1.11
142 p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J Biol Chem 2003 1.10
143 Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. J Cell Sci 2002 1.09
144 Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One 2010 1.09
145 VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med 2014 1.08
146 Mouse models for studying angiogenesis and lymphangiogenesis in cancer. Mol Oncol 2013 1.08
147 Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis. Invest Ophthalmol Vis Sci 2005 1.08
148 VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors. Cancer Cell 2008 1.07
149 Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 2009 1.07
150 Early lymph vessel development from embryonic stem cells. Arterioscler Thromb Vasc Biol 2006 1.06
151 Origins of serum semicarbazide-sensitive amine oxidase. Circ Res 2004 1.05
152 Double target for tumor mass destruction. J Clin Invest 2003 1.04
153 Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Res 2004 1.04
154 Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Res 2010 1.04
155 FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha. Oncogene 2002 1.03
156 Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema. J Physiol 2006 1.03
157 Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues. Int J Cancer 2004 1.03
158 Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest 2014 1.03
159 A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos. FASEB J 2002 1.02
160 A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development 2013 1.01
161 Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol 2013 1.01
162 An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J Biol Chem 2004 1.01
163 Growth factor therapy and autologous lymph node transfer in lymphedema. Circulation 2011 1.01
164 Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Mol Cancer 2011 1.00
165 VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013 1.00
166 Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report. Arterioscler Thromb Vasc Biol 2009 0.99
167 Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Sci Transl Med 2011 0.98
168 Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice. Mol Ther 2008 0.98
169 Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis. Semin Cell Dev Biol 2002 0.98
170 Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood 2010 0.97
171 Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development. FASEB J 2004 0.96
172 Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res 2008 0.96
173 CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation 2014 0.96
174 Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood 2011 0.96
175 Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering. FASEB J 2011 0.95
176 Insights into the molecular pathogenesis and targeted treatment of lymphedema. Ann N Y Acad Sci 2002 0.95
177 The bloody fate of endothelial stem cells. Genes Dev 2003 0.95
178 State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circ Res 2015 0.94
179 The VEGF family, the inside story. Cell 2007 0.94
180 Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns. J Biol Chem 2006 0.94
181 Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy. Circ Res 2006 0.94
182 FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci U S A 2010 0.94
183 Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Mol Biol Cell 2004 0.94
184 Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation 2013 0.94
185 Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds. FASEB J 2004 0.94
186 Vascular endothelial growth factor-D expression in human atherosclerotic lesions. Cardiovasc Res 2003 0.93
187 Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants. Am J Respir Crit Care Med 2006 0.93
188 The yin, the yang, and the angiopoietin-1. J Clin Invest 2011 0.92
189 PHD2 regulates arteriogenic macrophages through TIE2 signalling. EMBO Mol Med 2013 0.92
190 Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol 2008 0.92
191 Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity. Dis Model Mech 2010 0.92
192 Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Dev Cell 2002 0.92
193 Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cell Mol Life Sci 2013 0.92
194 Genesis and pathogenesis of lymphatic vessels. Cell Tissue Res 2003 0.91
195 Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. Int J Biochem Cell Biol 2003 0.91
196 Lymphangiogenesis in development and disease. Novartis Found Symp 2007 0.91
197 Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res 2008 0.91
198 Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Hum Gene Ther 2005 0.91
199 Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arterioscler Thromb Vasc Biol 2011 0.91
200 Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. PLoS One 2012 0.91
201 Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proc Natl Acad Sci U S A 2013 0.90
202 Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol 2010 0.90
203 Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Exp Cell Res 2003 0.90
204 Endostatin signaling and regulation of endothelial cell-matrix interactions. Adv Cancer Res 2005 0.90
205 Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 2014 0.90
206 Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res 2014 0.90
207 VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies. Nat Med 2002 0.89
208 Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood 2009 0.89
209 Perspectives on lymphangiogenesis and angiogenesis in cancer. J Surg Oncol 2011 0.89
210 Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses. J Cell Sci 2012 0.88
211 Role of synectin in lymphatic development in zebrafish and frogs. Blood 2010 0.88
212 Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma. Int J Cancer 2012 0.88
213 Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev 2010 0.88
214 The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer. Growth Factors 2002 0.88
215 Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood 2012 0.87
216 The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. J Immunol 2011 0.86
217 Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits. Circulation 2004 0.86
218 AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy. Mol Ther 2012 0.86
219 VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest 2014 0.85
220 Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One 2012 0.85
221 Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins. Circ Res 2007 0.85
222 The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal 2013 0.85
223 Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia. J Heart Lung Transplant 2005 0.84
224 Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation. Arterioscler Thromb Vasc Biol 2006 0.84
225 Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res 2012 0.83
226 Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol 2013 0.83
227 Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood 2013 0.83
228 Molecular pathways for lymphangiogenesis and their role in human disease. Novartis Found Symp 2007 0.83
229 PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts. Arterioscler Thromb Vasc Biol 2009 0.83
230 Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest 2016 0.82
231 The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development 2013 0.82
232 Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest 2016 0.82
233 Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. PLoS One 2012 0.82
234 Intravital imaging of intestinal lacteals unveils lipid drainage through contractility. J Clin Invest 2015 0.81
235 VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts. Arterioscler Thromb Vasc Biol 2007 0.81
236 Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest 2016 0.81
237 PROX1 is involved in progression of rectal neuroendocrine tumors, NETs. Virchows Arch 2015 0.81
238 Matrix reloaded to circulation hits the tumor target. Cancer Cell 2003 0.80
239 VEGF-D: a modifier of embryonic lymphangiogenesis. Blood 2008 0.80
240 Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice. PLoS One 2006 0.79
241 PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1. Blood 2012 0.79
242 Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema. J Invest Dermatol 2008 0.79
243 Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. J Clin Invest 2016 0.78
244 Inside bloody lymphatics. Blood 2010 0.78
245 HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. Eur J Clin Invest 2014 0.78
246 Preclinical safety, toxicology, and biodistribution study of adenoviral gene therapy with sVEGFR-2 and sVEGFR-3 combined with chemotherapy for ovarian cancer. Hum Gene Ther Clin Dev 2013 0.77
247 Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations. Angiogenesis 2012 0.77
248 The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features. Biochim Biophys Acta 2013 0.76
249 On the relationship of LDL and VEGFR1: not just a family affair. EMBO Rep 2007 0.76
250 Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants. Transpl Int 2013 0.75
251 Fifteen years of molecular lymphangiogenesis - an interview with Kari Alitalo by Tatiana Petrova. Int J Dev Biol 2011 0.75
252 Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat. J Heart Lung Transplant 2010 0.75
253 Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice. J Leukoc Biol 2006 0.75
254 [Lentiviruses to use]. Duodecim 2003 0.75
255 [Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance]. Duodecim 2014 0.75