VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.

PubWeight™: 12.96‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMC 2172999)

Published in J Cell Biol on June 16, 2003

Authors

Holger Gerhardt1, Matthew Golding, Marcus Fruttiger, Christiana Ruhrberg, Andrea Lundkvist, Alexandra Abramsson, Michael Jeltsch, Christopher Mitchell, Kari Alitalo, David Shima, Christer Betsholtz

Author Affiliations

1: Deparrment of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, Box 440, SE 405 30 Göteborg, Sweden.

Articles citing this

(truncated to the top 100)

Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol (2009) 9.87

Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89

Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest (2006) 6.12

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell (2009) 5.91

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59

Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell (2010) 4.99

The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol (2005) 4.54

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A (2007) 4.52

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest (2005) 4.09

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood (2010) 3.82

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature (2010) 3.70

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev (2003) 3.48

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest (2003) 3.31

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev (2005) 3.29

Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25

Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22

Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer (2010) 2.93

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med (2010) 2.88

The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer (2008) 2.67

The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61

The astrocyte odyssey. Prog Neurobiol (2008) 2.58

Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A (2004) 2.39

Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37

Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci U S A (2006) 2.36

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc (2009) 2.34

Contact-inhibited chemotaxis in de novo and sprouting blood-vessel growth. PLoS Comput Biol (2008) 2.33

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol (2009) 2.17

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell (2012) 2.14

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice. Nat Protoc (2010) 2.12

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09

Fluid forces control endothelial sprouting. Proc Natl Acad Sci U S A (2011) 2.09

Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol (2006) 2.08

Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06

Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure. Development (2008) 2.03

Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02

A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature (2013) 1.98

Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene (2008) 1.95

Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res (2012) 1.94

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol (2010) 1.92

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91

Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling. Dev Biol (2005) 1.90

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest (2007) 1.89

Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis (2003) 1.89

Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89

Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev (2007) 1.86

Local cortical tension by myosin II guides 3D endothelial cell branching. Curr Biol (2009) 1.85

Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci (2005) 1.85

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83

The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol (2008) 1.82

Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest (2012) 1.79

A computational tool for quantitative analysis of vascular networks. PLoS One (2011) 1.79

Imaging angiogenesis and the microenvironment. APMIS (2008) 1.77

TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76

Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev (2007) 1.76

A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis. Biophys J (2007) 1.74

A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell (2010) 1.72

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol (2010) 1.72

Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev Cell (2009) 1.72

Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella. J Cell Biol (2008) 1.70

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev (2007) 1.68

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. Blood (2011) 1.68

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression. Blood (2011) 1.66

Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev (2004) 1.65

Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev (2010) 1.64

Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev (2011) 1.63

VEGF and endothelial guidance in angiogenic sprouting. Organogenesis (2008) 1.63

Custom design of the cardiac microenvironment with biomaterials. Circ Res (2005) 1.63

The role of VEGF receptors in angiogenesis; complex partnerships. Cell Mol Life Sci (2006) 1.63

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62

Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62

Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Blood (2006) 1.62

The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am J Pathol (2004) 1.61

Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth. Am J Pathol (2006) 1.61

Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol (2014) 1.61

Tumor angiogenesis and vascular patterning: a mathematical model. PLoS One (2011) 1.59

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron (2011) 1.58

Biomechanical regulation of blood vessel growth during tissue vascularization. Nat Med (2009) 1.58

Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J Cell Biol (2007) 1.54

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell (2012) 1.53

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood (2012) 1.53

VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res (2015) 1.52

Diabetic retinopathy: targeting vasoregression. Diabetes (2011) 1.51

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol (2010) 1.50

Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol Biol Cell (2010) 1.49

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest (2010) 1.49

Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev (2007) 1.49

Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor. Blood (2015) 1.49

Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48

VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines. Blood (2011) 1.46

Building blood vessels--stem cell models in vascular biology. J Cell Biol (2007) 1.46

Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. Blood (2007) 1.45

Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development (2011) 1.44

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proc Natl Acad Sci U S A (2013) 1.44

Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer (2012) 1.44

Clinical significance of epithelial-mesenchymal transition. Clin Transl Med (2014) 1.44

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest (2011) 1.44

Articles cited by this

Angiogenesis in cancer and other diseases. Nature (2000) 28.28

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (1996) 16.92

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (1983) 15.43

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 15.15

The molecular biology of axon guidance. Science (1996) 11.90

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science (1997) 10.54

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell (1998) 10.32

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest (1999) 6.32

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A (1995) 5.66

sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell (2002) 5.66

Vasculogenesis. Annu Rev Cell Dev Biol (1995) 5.41

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res (1977) 5.19

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev (2002) 5.15

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science (1998) 5.07

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci (1995) 4.97

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A (1998) 4.48

Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell (2002) 3.84

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70

Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro. Lab Invest (1990) 3.28

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development (1996) 2.85

Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol (1999) 2.79

Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion. Invest Ophthalmol Vis Sci (2002) 2.46

Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis. Invest Ophthalmol Vis Sci (2002) 2.23

VEGF gene therapy: stimulating angiogenesis or angioma-genesis? Nat Med (2000) 2.13

PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron (1996) 2.10

VEGF: an update on biological and therapeutic aspects. Curr Opin Biotechnol (2000) 2.01

Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Lab Invest (1984) 1.99

A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J Biol Chem (1998) 1.98

Relationship between astrocytes, ganglion cells and vasculature of the retina. J Comp Neurol (1987) 1.88

In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev Cell (2002) 1.87

Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr Top Microbiol Immunol (1999) 1.79

A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J Biol Chem (1998) 1.66

The formation of capillary basement membranes during internal vascularization of the rat's cerebral cortex. Z Zellforsch Mikrosk Anat (1972) 1.64

Structures in focus--filopodia. Int J Biochem Cell Biol (2002) 1.63

Early vascularization of the embryonic cerebral cortex: Golgi and electron microscopic studies. J Comp Neurol (1985) 1.63

Development of the human retinal vasculature: cellular relations and VEGF expression. Exp Eye Res (1997) 1.59

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc Natl Acad Sci U S A (1999) 1.51

Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons. Curr Biol (2000) 1.48

Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model. In Vitro Cell Dev Biol Anim (2000) 1.22

Signaling reaches to new dimensions in Drosophila imaginal discs. Cell (2000) 1.21

The sensory-motor role of growth cone filopodia. Curr Opin Neurobiol (1995) 1.19

Cell fate choices in Drosophila tracheal morphogenesis. Bioessays (2000) 1.19

Vascular developmental biology: getting nervous. Curr Opin Genet Dev (2000) 1.15

Articles by these authors

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09

Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89

Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24

Endothelial/pericyte interactions. Circ Res (2005) 8.24

Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol (2007) 7.75

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42

Pericytes regulate the blood-brain barrier. Nature (2010) 6.62

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell (2007) 6.44

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell (2011) 6.12

Lymphangiogenesis: Molecular mechanisms and future promise. Cell (2010) 5.84

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol (2009) 5.55

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev (2002) 5.15

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 5.15

Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol (2011) 4.76

Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol (2002) 4.66

A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol (2002) 4.63

Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (2003) 4.40

Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003) 4.39

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest (2005) 4.09

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med (2009) 4.07

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J (2002) 3.99

Lymphangiogenesis and cancer metastasis. Nat Rev Cancer (2002) 3.90

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood (2010) 3.82

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80

Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 3.78

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 3.64

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev (2003) 3.48

Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst (2002) 3.44

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet (2004) 3.38

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med (2004) 3.32

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest (2003) 3.31

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev (2005) 3.29

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol (2009) 3.28

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27

Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22

The biology of vascular endothelial growth factors. Cardiovasc Res (2005) 3.22

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19

Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol (2002) 2.99

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood (2004) 2.95

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J (2002) 2.73

Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development (2002) 2.68

VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood (2006) 2.66

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat Genet (2013) 2.62

Pericytes limit tumor cell metastasis. J Clin Invest (2006) 2.55

VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood (2002) 2.52

Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol (2008) 2.49

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res (2005) 2.48

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature (2011) 2.47

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44

Pericytes and vascular stability. Exp Cell Res (2005) 2.39

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med (2011) 2.38

Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab (2007) 2.35

Signaling and functions of angiopoietin-1 in vascular protection. Circ Res (2006) 2.34

Pericytes and the pathogenesis of diabetic retinopathy. Diabetes (2002) 2.31

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood (2009) 2.30

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci U S A (2002) 2.30

Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med (2007) 2.29

Cytokine detection by antibody-based proximity ligation. Proc Natl Acad Sci U S A (2004) 2.29

VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ Res (2003) 2.25

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol (2003) 2.24

Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis (2008) 2.21

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol (2009) 2.17

Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res (2008) 2.15

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol (2004) 2.13

Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev Dyn (2004) 2.11

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors. Genes Chromosomes Cancer (2010) 2.11

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04

Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev (2005) 2.01

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. Mol Cell Neurosci (2004) 1.95

Perifoveal müller cell depletion in a case of macular telangiectasia type 2. Ophthalmology (2010) 1.92

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell (2006) 1.92

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest (2013) 1.92

The lymphatic vasculature: recent progress and paradigms. Annu Rev Cell Dev Biol (2005) 1.91

Analysis of mural cell recruitment to tumor vessels. Circulation (2002) 1.90

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest (2011) 1.88

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol (2008) 1.88

A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet (2004) 1.87

Biological basis of therapeutic lymphangiogenesis. Circulation (2011) 1.85