| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Toxicity testing in the 21st century: implications for human health risk assessment.
|
Risk Anal
|
2008
|
5.57
|
|
2
|
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
|
Arch Toxicol
|
2013
|
3.00
|
|
3
|
Inhaled carbon nanotubes reach the subpleural tissue in mice.
|
Nat Nanotechnol
|
2009
|
2.78
|
|
4
|
Reactive oxygen species as a signal in glucose-stimulated insulin secretion.
|
Diabetes
|
2007
|
2.59
|
|
5
|
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.
|
Toxicol Sci
|
2011
|
2.03
|
|
6
|
A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening.
|
Toxicol Sci
|
2012
|
1.81
|
|
7
|
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
|
Toxicol Appl Pharmacol
|
2009
|
1.63
|
|
8
|
Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.
|
Environ Health Perspect
|
2010
|
1.47
|
|
9
|
Organotypic liver culture models: meeting current challenges in toxicity testing.
|
Crit Rev Toxicol
|
2012
|
1.46
|
|
10
|
Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene.
|
Crit Rev Toxicol
|
2004
|
1.45
|
|
11
|
Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.
|
Toxicol Sci
|
2003
|
1.44
|
|
12
|
Application of biologically based computer modeling to simple or complex mixtures.
|
Environ Health Perspect
|
2002
|
1.42
|
|
13
|
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
|
Toxicol Sci
|
2010
|
1.30
|
|
14
|
A systems biology perspective on Nrf2-mediated antioxidant response.
|
Toxicol Appl Pharmacol
|
2009
|
1.25
|
|
15
|
A deterministic map of Waddington's epigenetic landscape for cell fate specification.
|
BMC Syst Biol
|
2011
|
1.21
|
|
16
|
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks.
|
Open Biol
|
2013
|
1.16
|
|
17
|
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages.
|
Toxicol Appl Pharmacol
|
2009
|
1.15
|
|
18
|
Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?
|
Environ Health Perspect
|
2013
|
1.14
|
|
19
|
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines.
|
Toxicol Sci
|
2004
|
1.13
|
|
20
|
The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative.
|
Arch Toxicol
|
2007
|
1.11
|
|
21
|
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome.
|
Diabetes
|
2012
|
1.10
|
|
22
|
Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.
|
Toxicol Sci
|
2013
|
1.10
|
|
23
|
New directions in toxicity testing.
|
Annu Rev Public Health
|
2011
|
1.09
|
|
24
|
Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways.
|
PLoS One
|
2011
|
1.09
|
|
25
|
Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element.
|
Toxicol Sci
|
2004
|
1.08
|
|
26
|
Dose-dependent transitions in mechanisms of toxicity: case studies.
|
Toxicol Appl Pharmacol
|
2004
|
1.08
|
|
27
|
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.
|
Environ Health Perspect
|
2010
|
1.07
|
|
28
|
Quantitative interpretation of human biomonitoring data.
|
Toxicol Appl Pharmacol
|
2008
|
1.07
|
|
29
|
Dose response relationship in anti-stress gene regulatory networks.
|
PLoS Comput Biol
|
2006
|
1.07
|
|
30
|
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.
|
Toxicol Sci
|
2007
|
1.07
|
|
31
|
Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule.
|
Crit Rev Toxicol
|
2011
|
1.07
|
|
32
|
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
|
Free Radic Biol Med
|
2011
|
1.07
|
|
33
|
t4 workshop report: Pathways of Toxicity.
|
ALTEX
|
2013
|
1.06
|
|
34
|
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.
|
Toxicol Sci
|
2013
|
1.03
|
|
35
|
Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment.
|
Toxicol Sci
|
2010
|
1.03
|
|
36
|
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
|
Hepatology
|
2010
|
1.03
|
|
37
|
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.
|
J Pharmacokinet Pharmacodyn
|
2012
|
1.02
|
|
38
|
Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response.
|
Biochem Biophys Res Commun
|
2011
|
1.02
|
|
39
|
Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid.
|
Toxicol Appl Pharmacol
|
2007
|
1.02
|
|
40
|
Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages.
|
J Toxicol Environ Health A
|
2013
|
1.00
|
|
41
|
A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure.
|
Toxicol Sci
|
2007
|
1.00
|
|
42
|
Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models.
|
Toxicol Sci
|
2010
|
0.99
|
|
43
|
Non-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression.
|
J Mol Endocrinol
|
2007
|
0.99
|
|
44
|
In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.
|
Environ Health Perspect
|
2002
|
0.98
|
|
45
|
Application of pharmacokinetic data to the risk assessment of inhaled manganese.
|
Neurotoxicology
|
2006
|
0.98
|
|
46
|
Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.
|
Toxicol Sci
|
2013
|
0.98
|
|
47
|
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
|
J Pharmacol Exp Ther
|
2012
|
0.98
|
|
48
|
A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift.
|
ALTEX
|
2010
|
0.96
|
|
49
|
The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.
|
Regul Toxicol Pharmacol
|
2006
|
0.96
|
|
50
|
Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis.
|
Toxicol Lett
|
2007
|
0.95
|
|
51
|
Dose-dependent transitions in mechanisms of toxicity.
|
Toxicol Appl Pharmacol
|
2004
|
0.95
|
|
52
|
Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta.
|
Brain Res
|
2006
|
0.94
|
|
53
|
Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine.
|
J Toxicol Environ Health A
|
2003
|
0.94
|
|
54
|
Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.
|
Crit Rev Toxicol
|
2012
|
0.93
|
|
55
|
Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action.
|
Toxicol Sci
|
2004
|
0.93
|
|
56
|
Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development.
|
Toxicol Sci
|
2011
|
0.92
|
|
57
|
Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions.
|
J Comp Neurol
|
2007
|
0.92
|
|
58
|
Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study.
|
Mutat Res
|
2012
|
0.92
|
|
59
|
Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response.
|
Toxicol In Vitro
|
2009
|
0.91
|
|
60
|
Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes.
|
Environ Health Perspect
|
2012
|
0.90
|
|
61
|
Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153.
|
Toxicol Pathol
|
2004
|
0.90
|
|
62
|
A framework for the next generation of risk science.
|
Environ Health Perspect
|
2014
|
0.89
|
|
63
|
Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study.
|
Environ Toxicol Chem
|
2011
|
0.89
|
|
64
|
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.
|
Toxicol Sci
|
2010
|
0.88
|
|
65
|
Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses.
|
Toxicol Appl Pharmacol
|
2009
|
0.88
|
|
66
|
Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK).
|
Environ Health Perspect
|
2015
|
0.88
|
|
67
|
Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling.
|
Am J Physiol Lung Cell Mol Physiol
|
2007
|
0.87
|
|
68
|
Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure.
|
J Toxicol Environ Health A
|
2008
|
0.87
|
|
69
|
Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat.
|
Inhal Toxicol
|
2003
|
0.86
|
|
70
|
Computational systems biology and dose-response modeling in relation to new directions in toxicity testing.
|
J Toxicol Environ Health B Crit Rev
|
2010
|
0.86
|
|
71
|
Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling.
|
J Occup Environ Hyg
|
2005
|
0.86
|
|
72
|
Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals.
|
Toxicol Sci
|
2009
|
0.86
|
|
73
|
Hormesis and adaptive cellular control systems.
|
Dose Response
|
2008
|
0.86
|
|
74
|
Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop.
|
Toxicol Sci
|
2011
|
0.86
|
|
75
|
Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure.
|
Toxicol Sci
|
2010
|
0.86
|
|
76
|
Binary gene induction and protein expression in individual cells.
|
Theor Biol Med Model
|
2006
|
0.86
|
|
77
|
Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.
|
Toxicol Sci
|
2002
|
0.86
|
|
78
|
Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response.
|
Environ Health Perspect
|
2012
|
0.86
|
|
79
|
Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach.
|
Inhal Toxicol
|
2003
|
0.85
|
|
80
|
Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model.
|
Toxicol Sci
|
2009
|
0.85
|
|
81
|
Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans.
|
Toxicol Sci
|
2006
|
0.85
|
|
82
|
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage.
|
Toxicol Appl Pharmacol
|
2012
|
0.85
|
|
83
|
A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice.
|
Arch Toxicol
|
2006
|
0.85
|
|
84
|
A dermatotoxicokinetic model of human exposures to jet fuel.
|
Toxicol Sci
|
2006
|
0.85
|
|
85
|
Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.
|
Reprod Toxicol
|
2011
|
0.84
|
|
86
|
Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling.
|
Toxicol Sci
|
2007
|
0.84
|
|
87
|
A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.
|
Environ Health Perspect
|
2002
|
0.84
|
|
88
|
PBPK modeling of complex hydrocarbon mixtures: gasoline.
|
Environ Toxicol Pharmacol
|
2004
|
0.84
|
|
89
|
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
|
Front Physiol
|
2012
|
0.84
|
|
90
|
Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine.
|
Chem Res Toxicol
|
2006
|
0.84
|
|
91
|
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation.
|
Inhal Toxicol
|
2008
|
0.84
|
|
92
|
Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin.
|
BMC Syst Biol
|
2010
|
0.83
|
|
93
|
t4 workshop report--lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program.
|
ALTEX
|
2013
|
0.83
|
|
94
|
Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene.
|
Crit Rev Toxicol
|
2005
|
0.83
|
|
95
|
Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration.
|
Regul Toxicol Pharmacol
|
2002
|
0.83
|
|
96
|
A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency.
|
Toxicol Sci
|
2008
|
0.83
|
|
97
|
Long-term stability of primary rat hepatocytes in micropatterned cocultures.
|
J Biochem Mol Toxicol
|
2013
|
0.83
|
|
98
|
Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells.
|
Free Radic Biol Med
|
2012
|
0.83
|
|
99
|
Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants.
|
Pharm Res
|
2013
|
0.83
|
|
100
|
In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.
|
Toxicol In Vitro
|
2011
|
0.83
|
|
101
|
Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats.
|
Toxicol Sci
|
2005
|
0.82
|
|
102
|
Dermal absorption and penetration of jet fuel components in humans.
|
Toxicol Lett
|
2006
|
0.82
|
|
103
|
Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model.
|
Regul Toxicol Pharmacol
|
2011
|
0.82
|
|
104
|
Development of an immunochemical detection method for atrazine-induced albumin adducts.
|
Chem Res Toxicol
|
2007
|
0.82
|
|
105
|
PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene.
|
Environ Health Perspect
|
2007
|
0.82
|
|
106
|
Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses.
|
Environ Health Perspect
|
2014
|
0.82
|
|
107
|
Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes.
|
Toxicol Appl Pharmacol
|
2013
|
0.81
|
|
108
|
Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action-based cancer risk assessment for chloroform.
|
Risk Anal
|
2007
|
0.81
|
|
109
|
Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH.
|
Environ Health Perspect
|
2009
|
0.81
|
|
110
|
Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model.
|
Reprod Toxicol
|
2011
|
0.81
|
|
111
|
Pharmacokinetic modeling of manganese. I. Dose dependencies of uptake and elimination.
|
J Toxicol Environ Health A
|
2007
|
0.81
|
|
112
|
Quantitative identification of atrazine and its chlorinated metabolites in plasma.
|
J Anal Toxicol
|
2003
|
0.81
|
|
113
|
In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat.
|
Toxicol In Vitro
|
2013
|
0.81
|
|
114
|
Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology.
|
Environ Toxicol Pharmacol
|
2004
|
0.81
|
|
115
|
Workshop overview: reassessment of the cancer risk of dichloromethane in humans.
|
Toxicol Sci
|
2006
|
0.80
|
|
116
|
Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment.
|
J Toxicol Environ Health B Crit Rev
|
2003
|
0.80
|
|
117
|
Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation.
|
J Toxicol Environ Health A
|
2007
|
0.80
|
|
118
|
Dose-response modeling of etoposide-induced DNA damage response.
|
Toxicol Sci
|
2013
|
0.80
|
|
119
|
Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose.
|
Toxicol Ind Health
|
2004
|
0.80
|
|
120
|
A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.
|
Reprod Toxicol
|
2012
|
0.80
|
|
121
|
Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model.
|
Toxicol Sci
|
2009
|
0.80
|
|
122
|
Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT-Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment.
|
J Toxicol
|
2012
|
0.80
|
|
123
|
Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kinetics.
|
J Toxicol Environ Health A
|
2007
|
0.79
|
|
124
|
Pollution trees: identifying similarities among complex pollutant mixtures in water and correlating them to mutagenicity.
|
Environ Sci Technol
|
2012
|
0.79
|
|
125
|
Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.
|
Inhal Toxicol
|
2002
|
0.79
|
|
126
|
Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches.
|
Toxicology
|
2007
|
0.79
|
|
127
|
Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling.
|
Toxicol In Vitro
|
2006
|
0.79
|
|
128
|
On the incorporation of chemical-specific information in risk assessment.
|
Toxicol Lett
|
2008
|
0.79
|
|
129
|
Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats.
|
Toxicology
|
2008
|
0.79
|
|
130
|
Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction.
|
Arch Toxicol
|
2012
|
0.79
|
|
131
|
Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
|
Toxicol Sci
|
2007
|
0.79
|
|
132
|
Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model.
|
Toxicol Sci
|
2004
|
0.79
|
|
133
|
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.
|
Antioxid Redox Signal
|
2015
|
0.78
|
|
134
|
Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages.
|
Toxicol Sci
|
2014
|
0.78
|
|
135
|
Physiologically based pharmacokinetic/toxicokinetic modeling.
|
Methods Mol Biol
|
2012
|
0.78
|
|
136
|
Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin.
|
Toxicol In Vitro
|
2013
|
0.78
|
|
137
|
Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats.
|
Reprod Toxicol
|
2012
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0.78
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