Published in Sci Signal on February 02, 2010
TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci (2012) 3.49
Beyond TGFβ: roles of other TGFβ superfamily members in cancer. Nat Rev Cancer (2013) 1.67
Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes Dis (2014) 1.27
BMPs and their clinical potentials. BMB Rep (2011) 1.11
Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells. PLoS One (2012) 1.05
Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium. Invest Ophthalmol Vis Sci (2012) 1.00
Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse. PLoS One (2012) 0.94
BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation. Am J Physiol Gastrointest Liver Physiol (2013) 0.94
Bone morphogenetic protein 2: a potential new player in the pathogenesis of diabetic retinopathy. Exp Eye Res (2014) 0.93
BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Dev Biol (2012) 0.93
BMP9 inhibits the proliferation and invasiveness of breast cancer cells MDA-MB-231. J Cancer Res Clin Oncol (2011) 0.91
Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells. Am J Transl Res (2015) 0.90
Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs. Front Physiol (2012) 0.89
BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways. PLoS One (2014) 0.87
Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate. Biomaterials (2014) 0.86
Insights into the osteoblast precursor differentiation towards mature osteoblasts induced by continuous BMP-2 signaling. Biol Open (2013) 0.85
Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications. Immunology (2011) 0.84
Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes. Arthritis Res Ther (2015) 0.83
The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation. Sci Rep (2015) 0.82
Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases. Int J Mol Sci (2014) 0.82
LIM mineralization protein-1 inhibits the malignant phenotypes of human osteosarcoma cells. Int J Mol Sci (2014) 0.82
BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells. PLoS One (2013) 0.81
Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair. World J Stem Cells (2016) 0.81
RPE and Choroid Mechanisms Underlying Ocular Growth and Myopia. Prog Mol Biol Transl Sci (2015) 0.80
Bone morphogenic protein-7 contributes to cerebral ischemic preconditioning induced-ischemic tolerance by activating p38 mitogen-activated protein kinase signaling pathway. Inflammation (2014) 0.80
Secondary structure of rhBMP-2 in a protective biopolymeric carrier material. Biomacromolecules (2012) 0.80
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS One (2015) 0.80
BMP signaling in telencephalic neural cell specification and maturation. Front Cell Neurosci (2013) 0.80
Effects of imposed defocus of opposite sign on temporal gene expression patterns of BMP4 and BMP7 in chick RPE. Exp Eye Res (2013) 0.79
Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway. Exp Cell Res (2013) 0.79
In situ guided tissue regeneration in musculoskeletal diseases and aging : Implementing pathology into tailored tissue engineering strategies. Cell Tissue Res (2011) 0.78
A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS One (2015) 0.78
A host-guest relationship in bone morphogenetic protein receptor-II defines specificity in ligand-receptor recognition. Biochemistry (2012) 0.78
Osteoblast maturation on microtextured titanium involves paracrine regulation of bone morphogenetic protein signaling. J Biomed Mater Res A (2014) 0.78
Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists. Stem Cells Transl Med (2016) 0.78
Protein kinase D1 is essential for bone acquisition during pubertal growth. Endocrinology (2013) 0.78
Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions. World J Surg Oncol (2013) 0.77
Inhibitory Effect of Bone Morphogenetic Protein 4 in Retinal Pigment Epithelial-Mesenchymal Transition. Sci Rep (2016) 0.76
Association of genetic variants of BMP4 with type 2 diabetes mellitus and clinical traits in a Chinese Han population. Biomed Res Int (2013) 0.76
A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro. Mol Cells (2016) 0.75
A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives. Stem Cells Int (2016) 0.75
Rhizoma Dioscoreae extract protects against alveolar bone loss in ovariectomized rats via microRNAs regulation. Nutrients (2015) 0.75
Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors. Hum Reprod Update (2016) 0.75
Membrane nanowaves in single and collective cell migration. PLoS One (2014) 0.75
Effects and mechanisms of a microcurrent dressing on skin wound healing: a review. Mil Med Res (2014) 0.75
Autosomal dominant mesomandibular fibro-osseous dysplasia: a self-resolving inherited fibro-osseous lesion of the jaws. Front Physiol (2012) 0.75
Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation. Inflammation (2017) 0.75
Evaluation of complications associated with off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in pediatric orthopaedics. J Mater Sci Mater Med (2016) 0.75
Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension. Circulation (2017) 0.75
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Signal transduction of bone morphogenetic protein receptors. Cell Signal (2004) 3.11
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem (2001) 2.59
Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev (2009) 2.57
Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol (2006) 1.99
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. J Clin Invest (2005) 1.88
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A (2003) 1.52
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva. J Biol Chem (2012) 1.43
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol (2007) 1.43
MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites. PLoS One (2011) 1.41
A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. J Natl Cancer Inst (2008) 1.29
p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci (2006) 1.28
Tumor necrosis factor-alpha promotes malignant pleural effusion. Cancer Res (2007) 1.27
Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells. BMC Genomics (2007) 1.25
Integration of the TGF-beta pathway into the cellular signalling network. Cell Signal (2002) 1.23
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells. Brain (2010) 1.23
Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J Cell Sci (2005) 1.21
A portrait of Transforming Growth Factor β superfamily signalling: Background matters. Int J Biochem Cell Biol (2011) 1.21
Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Proteomics (2004) 1.20
Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol (2008) 1.19
Cell fate determination during tooth development and regeneration. Birth Defects Res C Embryo Today (2009) 1.18
Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling. Cell Signal (2011) 1.18
Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes. J Bone Joint Surg Am (2003) 1.18
Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells. J Physiol (2003) 1.13
Noggin. Int J Biochem Cell Biol (2011) 1.12
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol (2009) 1.10
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. J Exp Med (2013) 1.08
A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2. Eur J Hum Genet (2006) 1.07
A butyrophilin family member critically inhibits T cell activation. J Immunol (2010) 1.04
Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Genes Cells (2004) 1.03
Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex. J Exp Zool B Mol Dev Evol (2009) 1.02
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells Dev (2012) 1.01
Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol (2009) 1.00
Oligomeric interactions of TGF-β and BMP receptors. FEBS Lett (2012) 0.99
miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules. Int J Biochem Cell Biol (2012) 0.99
BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway. BMC Biol (2012) 0.99
Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity. EMBO J (2009) 0.97
New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling. Curr Opin Genet Dev (2009) 0.97
Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol (2009) 0.97
Constitutively active ALK2 receptor mutants require type II receptor cooperation. Mol Cell Biol (2013) 0.96
Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse. PLoS One (2012) 0.94
BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Dev Biol (2012) 0.93
B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate. J Immunol (2006) 0.93
Nerve growth factor mediates activation of the Smad pathway in PC12 cells. Eur J Biochem (2004) 0.93
Noggin null allele mice exhibit a microform of holoprosencephaly. Hum Mol Genet (2011) 0.92
BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development (2010) 0.92
Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways. J Cell Sci (2003) 0.91
BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell Tissue Res (2012) 0.91
The genetic basis of craniofacial and dental abnormalities. Schweiz Monatsschr Zahnmed (2011) 0.90
Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs. Front Physiol (2012) 0.89
Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity. J Cell Sci (2010) 0.89
PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1. J Cell Sci (2009) 0.88
Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2. Stem Cells (2014) 0.88
Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Wiley Interdiscip Rev Dev Biol (2014) 0.88
Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Lett (2015) 0.87
Formation of stable homomeric and transient heteromeric bone morphogenetic protein (BMP) receptor complexes regulates Smad protein signaling. J Biol Chem (2011) 0.87
SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors. J Biol Chem (2012) 0.87
A member of the transforming growth factor-beta receptor family from Echinococcus multilocularis is activated by human bone morphogenetic protein 2. Mol Biochem Parasitol (2006) 0.86
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia. PLoS One (2012) 0.86
New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res (2012) 0.86
Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation. Acta Biomater (2011) 0.86
Covalent quantum dot receptor linkage via the acyl carrier protein for single-molecule tracking, internalization, and trafficking studies. Biotechniques (2010) 0.85
Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor. Cancer Detect Prev (2004) 0.85
The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding. FEBS J (2009) 0.85
MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. J Bone Miner Res (2015) 0.84
BMP growth factor signaling in a biomechanical context. Biofactors (2013) 0.84
BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells. Biomaterials (2013) 0.84
Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications. Immunology (2011) 0.84
Biochemical and functional characterization of the Ror2/BRIb receptor complex. Biochem Biophys Res Commun (2009) 0.83
Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res (2010) 0.83
Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis. Front Physiol (2012) 0.83
Comprehensive analysis of TGF-β and BMP receptor interactomes. Eur J Cell Biol (2011) 0.83
The "artificial artery" as in vitro perfusion model. PLoS One (2013) 0.82
Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS One (2011) 0.82
The etiology of cleft palate formation in BMP7-deficient mice. PLoS One (2013) 0.82
Characterization of B7S3 as a novel negative regulator of T cells. J Immunol (2007) 0.82
Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci (2013) 0.82
Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor. J Cell Physiol (2006) 0.81
Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo. PLoS One (2012) 0.81
Modulation of matrix metalloprotease-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formation. Tissue Eng Part A (2010) 0.81
Involvement of twisted gastrulation in T cell-independent plasma cell production. J Immunol (2011) 0.81
Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer. Rapid Commun Mass Spectrom (2007) 0.80
Antagonism of GxxPG fragments ameliorates manifestations of aortic disease in Marfan syndrome mice. Hum Mol Genet (2012) 0.80
Molecular characterisation of a second structurally unusual AR-Smad without an MH1 domain and a Smad4 orthologue from Echinococcus multilocularis. Int J Parasitol (2007) 0.79
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis. PLoS One (2013) 0.78
Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity. Biol Chem (2006) 0.77
Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica (2014) 0.76
Identification and characterisation of two distinct Smad proteins from the fox-tapeworm Echinococcus multilocularis. Int J Parasitol (2003) 0.76
Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices. Rapid Commun Mass Spectrom (2007) 0.75
A unique automation platform for measuring low level radioactivity in metabolite identification studies. PLoS One (2012) 0.75
A Focused Low-Intensity Pulsed Ultrasound (FLIPUS) System for Cell Stimulation: Physical and Biological Proof of Principle. IEEE Trans Ultrason Ferroelectr Freq Control (2015) 0.75
Resistance to TGF-beta1-mediated growth inhibition correlates with sustained Smad2 phosphorylation in primary murine splenocytes. Eur J Immunol (2002) 0.75
Cytostar-T plates--a valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies? J Chromatogr A (2007) 0.75
Activation of Mechanosensitive Transcription Factors in Murine C2C12 Mesenchymal Precursors by Focused Low-Intensity Pulsed Ultrasound (FLIPUS). IEEE Trans Ultrason Ferroelectr Freq Control (2016) 0.75