Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.

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Published in J Med Chem on March 11, 2010

Authors

Paul P Geurink1, Nora Liu, Michiel P Spaans, Sondra L Downey, Adrianus M C H van den Nieuwendijk, Gijsbert A van der Marel, Alexei F Kisselev, Bogdan I Florea, Herman S Overkleeft

Author Affiliations

1: Leiden Institute of Chemistry and Netherlands Proteomics Centre, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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