Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.

PubWeight™: 1.64‹?› | Rank: Top 3%

🔗 View Article (PMC 2196045)

Published in J Exp Med on August 19, 2002

Authors

Ana-Maria Lennon-Duménil1, Arnold H Bakker, René Maehr, Edda Fiebiger, Herman S Overkleeft, Mario Rosemblatt, Hidde L Ploegh, Cécile Lagaudrière-Gesbert

Author Affiliations

1: Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

Articles citing this

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB. Proc Natl Acad Sci U S A (2003) 2.96

Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol (2008) 2.53

Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion. Cold Spring Harb Perspect Biol (2013) 2.00

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity (2009) 1.82

Fungal effector protein AVR2 targets diversifying defense-related cys proteases of tomato. Plant Cell (2008) 1.64

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell (2004) 1.44

The macrophage marches on its phagosome: dynamic assays of phagosome function. Nat Rev Immunol (2009) 1.43

Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation. BMC Bioinformatics (2007) 1.37

Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches. Infect Immun (2003) 1.29

How B cells capture, process and present antigens: a crucial role for cell polarity. Nat Rev Immunol (2013) 1.29

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A (2009) 1.29

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes. Proc Natl Acad Sci U S A (2010) 1.28

The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages. Infect Immun (2006) 1.22

Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol Biol Cell (2003) 1.18

Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. Am J Respir Crit Care Med (2008) 1.16

Phagosome maturation during the removal of apoptotic cells: receptors lead the way. Trends Cell Biol (2008) 1.15

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem Biol (2010) 1.13

Autonomous phagosomal degradation and antigen presentation in dendritic cells. Proc Natl Acad Sci U S A (2012) 0.98

Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells. PLoS One (2014) 0.97

The Role of FcRn in Antigen Presentation. Front Immunol (2014) 0.93

Intracellular events regulating cross-presentation. Front Immunol (2012) 0.93

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations. Front Immunol (2012) 0.93

Antigen release kinetics in the phagosome are critical to cross-presentation efficiency. J Immunol (2008) 0.91

Mechanisms of dendritic cell lysosomal killing of Cryptococcus. Sci Rep (2012) 0.89

Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis. Microbes Infect (2010) 0.88

Decidual macrophages and their roles at the maternal-fetal interface. Yale J Biol Med (2012) 0.86

The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues. Semin Immunopathol (2016) 0.85

Antigen cross-presentation: extending recent laboratory findings to therapeutic intervention. Clin Exp Immunol (2011) 0.85

A Candida albicans mannoprotein deprived of its mannan moiety is efficiently taken up and processed by human dendritic cells and induces T-cell activation without stimulating proinflammatory cytokine production. Infect Immun (2008) 0.84

GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity. Eur J Immunol (2012) 0.84

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets. Front Immunol (2015) 0.83

Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity. Sci Rep (2015) 0.81

Cytokines regulate cysteine cathepsins during TLR responses. Cell Immunol (2010) 0.81

Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. J Immunol (2015) 0.81

Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes. Immunology (2004) 0.80

Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro. Immunology (2007) 0.80

The comings and goings of MHC class I molecules herald a new dawn in cross-presentation. Immunol Rev (2016) 0.80

Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis. Eur J Immunol (2014) 0.79

γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages. J Biol Chem (2014) 0.79

Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjug Chem (2009) 0.78

The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization. PLoS One (2012) 0.78

Endosomal processing for antigen presentation mediated by CD1 and Class I major histocompatibility complex: roads to display or destruction. Immunology (2009) 0.78

Intracellular regulation of cross-presentation during dendritic cell maturation. PLoS One (2013) 0.78

A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood (2012) 0.77

Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease. Periodontol 2000 (2015) 0.75

Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner. PLoS Negl Trop Dis (2016) 0.75

Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets. J Immunol (2016) 0.75

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity. Toxicol Appl Pharmacol (2017) 0.75

Cationic liposomes promote antigen cross-presentation in dendritic cells by alkalizing the lysosomal pH and limiting the degradation of antigens. Int J Nanomedicine (2017) 0.75

Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Cell Mol Bioeng (2017) 0.75

Articles cited by this

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13

The phagosome proteome: insight into phagosome functions. J Cell Biol (2001) 4.23

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature (1994) 3.55

Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol (1997) 3.24

Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity (1996) 2.93

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem Biol (2000) 2.84

Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). Proc Natl Acad Sci U S A (2000) 2.40

How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol (1995) 2.24

Defective antigen processing in GILT-free mice. Science (2001) 2.16

Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell (1998) 1.86

How MHC class II molecules reach the endocytic pathway. EMBO J (1995) 1.80

Mechanisms of antigen uptake for presentation. Curr Opin Immunol (1996) 1.68

Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes. J Biol Chem (1998) 1.67

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem Biol (2000) 1.62

Proteases involved in MHC class II antigen presentation. Immunol Rev (1999) 1.54

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med (2000) 1.49

Antigen processing for amateurs and professionals. Trends Cell Biol (1998) 1.44

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J Exp Med (1995) 1.44

Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr Biol (2001) 1.43

The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation. Immunol Rev (1999) 1.37

Antigen processing in the endocytic compartment. Curr Opin Immunol (2001) 1.36

A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Curr Opin Immunol (2002) 1.32

Neutrophils process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes. J Immunol (2001) 1.31

Different fates of phagocytosed particles after delivery into macrophage lysosomes. J Cell Biol (1996) 1.31

Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem (1993) 1.25

Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosomes. J Cell Sci (1997) 1.23

Endosomal proteolysis and MHC class II function. Curr Opin Immunol (1998) 1.22

Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes. J Immunol (1999) 1.17

Procathepsins L and D are membrane-bound in acidic microsomal vesicles. J Biol Chem (1991) 1.03

The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J (2001) 1.00

Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors. J Med Chem (1996) 0.94

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties. Eur J Immunol (1999) 0.91

Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors. Eur J Immunol (2001) 0.87

Articles by these authors

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature (2003) 7.56

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med (2007) 5.96

A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15

Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72

Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature (2002) 3.93

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43

Sortagging: a versatile method for protein labeling. Nat Chem Biol (2007) 3.39

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31

Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19

A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 3.01

A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol (2006) 2.94

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci (2012) 2.90

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain. Science (2008) 2.88

The known unknowns of antigen processing and presentation. Nat Rev Immunol (2008) 2.85

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem (2004) 2.75

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nat Methods (2009) 2.57

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure (2006) 2.56

Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity (2011) 2.50

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol Cell (2005) 2.43

Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis (2008) 2.40

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2008) 2.38

Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood (2004) 2.37

Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34

Proteasome inhibitors: an expanding army attacking a unique target. Chem Biol (2012) 2.26

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol (2011) 2.23

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem (2003) 2.22

A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J (2003) 2.18

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13

Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J (2009) 2.12

Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc (2007) 2.10

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09

Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol (2006) 2.05

Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03

Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00

The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes (2010) 1.91

Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol (2007) 1.90

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol (2005) 1.85

Ubiquitin-like proteins. Annu Rev Biochem (2012) 1.84

Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. J Immunol (2009) 1.84

Antigen bias in T cell cross-priming. Science (2004) 1.82

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82

Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol (2006) 1.78

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods (2005) 1.78

Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nat Protoc (2012) 1.76

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell (2007) 1.75

Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (2010) 1.74

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature (2006) 1.73

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J (2009) 1.72

Identification of proteins associated with murine cytomegalovirus virions. J Virol (2004) 1.72

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem (2005) 1.71

Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host Microbe (2009) 1.69

Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68

Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. J Am Chem Soc (2009) 1.63

Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol (2006) 1.62

Thioglycosides in sequential glycosylation strategies. Chem Soc Rev (2005) 1.60

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development (2014) 1.59

Making and breaking peptide bonds: protein engineering using sortase. Angew Chem Int Ed Engl (2011) 1.58

Screen for ISG15-crossreactive deubiquitinases. PLoS One (2007) 1.57

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J (2007) 1.56

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem Biol (2006) 1.54

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J (2004) 1.53

Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. Eur J Immunol (2011) 1.52

High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J Virol (2006) 1.52

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc Natl Acad Sci U S A (2008) 1.51

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol (2005) 1.50

Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol (2002) 1.50

Epithelial control of the human pDC response to extracellular bacteria. Eur J Immunol (2013) 1.47

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol (2009) 1.47

Identification of host cell factors required for intoxication through use of modified cholera toxin. J Cell Biol (2011) 1.47

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem (2003) 1.46

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell (2004) 1.44

Synthesis of pH-activatable red fluorescent BODIPY dyes with distinct functionalities. Org Lett (2011) 1.44

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A (2011) 1.44

Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A (2008) 1.43

Site-specific protein labeling via sortase-mediated transpeptidation. Curr Protoc Protein Sci (2009) 1.43

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunol Rev (2005) 1.43

Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol (2004) 1.42

Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides. Org Lett (2003) 1.42