Published in Methods Mol Biol on January 01, 2010
MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncol Rep (2013) 0.96
TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression. PLoS One (2013) 0.95
Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One (2013) 0.95
Ultrasound enhanced matrix metalloproteinase-9 triggered release of contents from echogenic liposomes. Mol Pharm (2012) 0.90
The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock. Toxins (Basel) (2011) 0.88
Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9. Bioorg Med Chem Lett (2011) 0.86
Comparative Analysis of Matrix Metalloproteinase Family Members Reveals That MMP9 Predicts Survival and Response to Temozolomide in Patients with Primary Glioblastoma. PLoS One (2016) 0.75
Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity. Chem Rev (2005) 4.48
Tackling antibiotic resistance. Nat Rev Microbiol (2011) 3.95
Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev (2003) 3.72
Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci (2005) 2.54
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res (2008) 1.88
Potent mechanism-based inhibitors for matrix metalloproteinases. J Biol Chem (2005) 1.83
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proc Natl Acad Sci U S A (2013) 1.75
The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J Biol Chem (2004) 1.74
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. J Am Chem Soc (2005) 1.67
Recent advances in MMP inhibitor design. Cancer Metastasis Rev (2006) 1.66
Bacterial cell-wall recycling. Ann N Y Acad Sci (2012) 1.60
Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrob Agents Chemother (2009) 1.51
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples. Chem Biol (2006) 1.50
Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. J Am Chem Soc (2008) 1.50
Cell surface association of matrix metalloproteinase-9 (gelatinase B). Cancer Metastasis Rev (2003) 1.45
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chem Biol (2002) 1.42
Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. J Biol Chem (2003) 1.38
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Res (2005) 1.36
The future of the β-lactams. Curr Opin Microbiol (2010) 1.36
High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase. J Am Chem Soc (2002) 1.36
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. J Org Chem (2004) 1.33
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. Biochemistry (2005) 1.32
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor. Int J Cancer (2006) 1.32
Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. J Am Chem Soc (2009) 1.31
Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance. J Biol Chem (2011) 1.30
Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. Biochemistry (2007) 1.28
Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases. J Biol Chem (2009) 1.28
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2007) 1.27
Extracellular proteases as targets for treatment of cancer metastases. Chem Soc Rev (2004) 1.26
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. Biochemistry (2006) 1.25
Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. FASEB J (2011) 1.25
Design of novel antibiotics that bind to the ribosomal acyltransfer site. J Am Chem Soc (2002) 1.23
Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime. Antimicrob Agents Chemother (2002) 1.23
Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall. J Am Chem Soc (2005) 1.22
The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins. J Biol Chem (2004) 1.22
Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. J Am Chem Soc (2008) 1.21
Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. J Am Chem Soc (2013) 1.21
Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. J Biol Chem (2009) 1.21
Synthesis of a fragment of bacterial cell wall. J Org Chem (2004) 1.20
Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. J Am Chem Soc (2009) 1.19
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma. J Am Chem Soc (2007) 1.19
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. J Am Chem Soc (2003) 1.18
Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry (2012) 1.17
Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proc Natl Acad Sci U S A (2006) 1.17
Three decades of the class A beta-lactamase acyl-enzyme. Curr Protein Pept Sci (2009) 1.17
X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. J Am Chem Soc (2004) 1.15
Synthetic peptidoglycan motifs for germination of bacterial spores. Chembiochem (2010) 1.12
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme. J Biol Chem (2002) 1.12
Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics. J Am Chem Soc (2014) 1.11
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases. Chem Biol Drug Des (2009) 1.11
Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab (2009) 1.10
Metabolism of a highly selective gelatinase inhibitor generates active metabolite. Chem Biol Drug Des (2007) 1.10
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. J Am Chem Soc (2014) 1.10
Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study. Stroke (2012) 1.10
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener (2012) 1.10
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth. Am J Pathol (2007) 1.09
Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. J Biol Chem (2010) 1.09
Short alkylated peptoid mimics of antimicrobial lipopeptides. Antimicrob Agents Chemother (2010) 1.08
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors. Org Lett (2005) 1.08
Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. J Am Chem Soc (2002) 1.08
Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. Chem Biol (2013) 1.08
Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity. J Biol Chem (2004) 1.07
A practical synthesis of nitrocefin. J Org Chem (2005) 1.07
Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. J Am Chem Soc (2013) 1.06
Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1. J Biol Chem (2007) 1.06
Crystal structures of penicillin-binding protein 6 from Escherichia coli. J Am Chem Soc (2009) 1.05
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases. J Biol Chem (2002) 1.04
Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. Biochemistry (2009) 1.04
Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. J Am Chem Soc (2007) 1.03
Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance. Bioorg Chem (2004) 1.03
Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib. Biochemistry (2007) 1.02
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents. Brain Res (2006) 1.02
Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli. Biochemistry (2007) 1.02
Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. Nat Struct Mol Biol (2010) 1.01
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition. Chem Biol Drug Des (2009) 1.00
Crystal structures of bacterial peptidoglycan amidase AmpD and an unprecedented activation mechanism. J Biol Chem (2011) 1.00
Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus. J Biol Chem (2006) 1.00
Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases. J Biol Chem (2013) 1.00
Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism. Biochemistry (2011) 1.00
Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae. EMBO Rep (2009) 0.99
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. Chem Biol (2006) 0.98
Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. PLoS One (2013) 0.98
Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations. J Am Chem Soc (2008) 0.98
Quest for selectivity in inhibition of matrix metalloproteinases. Curr Top Med Chem (2004) 0.97
Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2). J Biol Chem (2003) 0.97
Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus. Biochemistry (2012) 0.97
The bifunctional enzymes of antibiotic resistance. Curr Opin Microbiol (2009) 0.96
Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. FEBS Lett (2010) 0.96
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A. J Org Chem (2005) 0.96
A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. J Am Chem Soc (2011) 0.96
Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. J Biol Chem (2011) 0.96
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. Biochemistry (2010) 0.95
Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem (2011) 0.95
Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. J Am Chem Soc (2003) 0.95
Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme. J Biol Chem (2006) 0.94
Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor. Chem Biol Drug Des (2008) 0.94
Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Biochemistry (2007) 0.93
Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a. J Biol Chem (2008) 0.93