Published in Steroids on February 04, 2010
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology (2010) 1.29
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression. Mol Endocrinol (2012) 0.85
Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell (2015) 0.83
Pathway based analysis of genes and interactions influencing porcine testis samples from boars with divergent androstenone content in back fat. PLoS One (2014) 0.75
Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment. J Assist Reprod Genet (2014) 0.75
Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab (2007) 6.83
Functions of ceramide in coordinating cellular responses to stress. Science (1996) 5.54
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell (1994) 4.55
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell (2006) 4.13
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature (1993) 3.58
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev (2004) 3.58
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta (2006) 3.10
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol (1999) 2.87
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes (2004) 2.86
Structural and functional characteristics of S1P receptors. J Cell Biochem (2004) 2.75
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat Med (2004) 2.71
Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta (2002) 2.69
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol (1998) 2.54
Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem (2002) 2.42
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem (1989) 2.32
The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest (2002) 2.30
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta (2008) 2.25
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J Biol Chem (1999) 2.22
Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest (1996) 2.21
Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system. Science (1992) 2.13
Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer. J Biol Chem (1998) 2.08
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem (1986) 2.00
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev (1994) 1.97
Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res (2002) 1.93
Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J Biol Chem (1999) 1.90
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem (2004) 1.84
Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Mol Pharmacol (2007) 1.79
Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem (2006) 1.76
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res (2002) 1.69
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J Biol Chem (1999) 1.62
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res (2007) 1.61
Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem (2002) 1.57
A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liver. J Hepatol (1999) 1.53
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J Cell Biol (2006) 1.52
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc Natl Acad Sci U S A (2009) 1.49
Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem (2008) 1.49
The role of intranuclear lipids. Biol Cell (2004) 1.46
Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochem Pharmacol (1999) 1.44
The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. J Biol Chem (2009) 1.38
Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev (1993) 1.38
Ceramide mediates caspase-independent programmed cell death. FASEB J (2005) 1.36
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. J Biol Chem (2007) 1.35
Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol Endocrinol (2003) 1.35
Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. Cell Signal (2006) 1.35
Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol (2002) 1.34
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology (2006) 1.34
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. Biochem Soc Trans (2003) 1.33
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol (2005) 1.33
Mass spectrometric identification of increased C16 ceramide levels during apoptosis. J Biol Chem (1999) 1.32
Cytokines and steroidogenesis. Mol Cell Endocrinol (2004) 1.31
Translational aspects of sphingolipid metabolism. Trends Mol Med (2007) 1.31
Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res (2009) 1.29
ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex. Microsc Res Tech (2003) 1.28
Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta (2002) 1.27
The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. implications for the control of adrenal functional zonation. J Biol Chem (2004) 1.27
The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem Cell Biol (1995) 1.26
Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim Biophys Acta (2006) 1.25
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem (2001) 1.24
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Arch Biochem Biophys (1995) 1.23
The regulation of aldosterone synthase expression. Mol Cell Endocrinol (2004) 1.22
Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem (2005) 1.21
The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev (2008) 1.21
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol Endocrinol (2003) 1.21
GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1. Mol Endocrinol (2004) 1.20
Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem J (1997) 1.19
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol (2007) 1.17
Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proc Natl Acad Sci U S A (2004) 1.17
Traveling for the glycosphingolipid path. Glycoconj J (2001) 1.16
Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology (2002) 1.16
Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res (2003) 1.15
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem (1999) 1.13
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology (2009) 1.13
Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood (2002) 1.12
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ (2001) 1.12
Neurosteroid regulation of central nervous system development. Pharmacol Ther (2007) 1.12
Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol (2006) 1.12
Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. J Biol Chem (2005) 1.12
Minireview: transcriptional regulation of adrenocortical development. Endocrinology (2004) 1.10
Basic concepts and recent developments in human steroid hormone biosynthesis. Rev Endocr Metab Disord (2007) 1.10
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int J Cancer (1996) 1.09
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem (2006) 1.08
Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. J Mol Endocrinol (2003) 1.07
Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. J Alzheimers Dis (2009) 1.07
Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. J Biol Chem (1997) 1.06
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med (Berl) (2009) 1.06
Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways. Cell Signal (2007) 1.05
Nuclear sphingolipids: metabolism and signaling. J Lipid Res (2008) 1.05
GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis. Endocrinology (2003) 1.05
Ovarian steroids: the good, the bad, and the signals that raise them. Cell Cycle (2006) 1.05
Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res Rev (2007) 1.05
Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosis. Cancer Res (2004) 1.03
Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol (2008) 1.03
Ceramide mediates tumor-induced dendritic cell apoptosis. J Immunol (2001) 1.01
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology (2006) 1.34
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol (2007) 1.17
Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate. Mol Endocrinol (2006) 1.16
Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol (2006) 1.12
Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem (2008) 0.98
Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem (2011) 0.96
Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology (2005) 0.95
Multiple roles for sphingolipids in steroid hormone biosynthesis. Subcell Biochem (2008) 0.91
Nuclear sphingolipid metabolism. Annu Rev Physiol (2011) 0.89
RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking. Endocrinology (2010) 0.87
ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocr Res (2004) 0.86
The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Biochim Biophys Acta (2009) 0.86
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression. Mol Endocrinol (2012) 0.85
cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1. J Lipid Res (2013) 0.83
Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. Mol Cell Endocrinol (2007) 0.81
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology (2012) 0.80
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor. Mol Cell Biol (2012) 0.80
Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. Mol Cell Endocrinol (2011) 0.80
Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem J (2013) 0.79
cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells. Mol Biol Cell (2013) 0.79