Published in Tissue Eng Part B Rev on February 01, 2010
Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev (2012) 1.57
Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Mol Ther (2011) 1.10
Engineering biomaterial systems to enhance viral vector gene delivery. Mol Ther (2011) 1.07
Gene therapy for bone healing. Expert Rev Mol Med (2010) 1.02
PTH promotes allograft integration in a calvarial bone defect. Mol Pharm (2013) 0.99
Gene therapy for the regeneration of bone. Injury (2011) 0.98
Gene therapy approaches to regenerating bone. Adv Drug Deliv Rev (2012) 0.97
Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair. Mol Ther (2010) 0.94
Gene delivery to bone. Adv Drug Deliv Rev (2012) 0.93
Controlled release strategies for bone, cartilage, and osteochondral engineering--Part I: recapitulation of native tissue healing and variables for the design of delivery systems. Tissue Eng Part B Rev (2013) 0.90
Evaluation of fibrin-based gene-activated matrices for BMP2/7 plasmid codelivery in a rat nonunion model. Int Orthop (2014) 0.83
Adeno-associated virus-coated allografts: a novel approach for cranioplasty. J Tissue Eng Regen Med (2012) 0.82
Effect of a novel nonviral gene delivery of BMP-2 on bone healing. ScientificWorldJournal (2012) 0.78
The use of scaffolds in musculoskeletal tissue engineering. Open Orthop J (2011) 0.78
BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study. Stem Cells Int (2015) 0.78
Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts. Bioengineering (Basel) (2016) 0.77
Effectiveness of synthetic hydroxyapatite versus Persian Gulf coral in an animal model of long bone defect reconstruction. J Orthop Traumatol (2013) 0.76
Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model. J Orthop Traumatol (2014) 0.75
Sustained release poly (lactic-co-glycolic acid) microspheres of bone morphogenetic protein 2 plasmid/calcium phosphate to promote in vitro bone formation and in vivo ectopic osteogenesis. Am J Transl Res (2015) 0.75
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab (2003) 5.27
Morbidity at bone graft donor sites. J Orthop Trauma (1989) 4.99
The cell and molecular biology of fracture healing. Clin Orthop Relat Res (1998) 4.65
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol (2008) 2.88
Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med (1999) 2.84
Tumor ablation with irreversible electroporation. PLoS One (2007) 2.66
Combat wounds in operation Iraqi Freedom and operation Enduring Freedom. J Trauma (2008) 2.61
Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg Br (1989) 2.43
Infection in bone allografts. Incidence, nature, and treatment. J Bone Joint Surg Am (1988) 2.24
Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials. BMJ (2009) 2.15
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med (2005) 2.10
Retrieved human allografts : a clinicopathological study. J Bone Joint Surg Am (2001) 2.02
Factors affecting nonunion of the allograft-host junction. Clin Orthop Relat Res (2001) 1.83
Transplantation immunity in bone homografting. J Bone Joint Surg Br (1959) 1.73
The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg (1990) 1.73
Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients. Ann Surg Oncol (2008) 1.65
Characterization of extremity wounds in Operation Iraqi Freedom and Operation Enduring Freedom. J Orthop Trauma (2007) 1.63
Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther (2001) 1.63
Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc Natl Acad Sci U S A (1996) 1.61
Fractures of allografts. Frequency, treatment, and end-results. J Bone Joint Surg Am (1990) 1.57
Allograft bone decreases in strength in vivo over time. Clin Orthop Relat Res (2005) 1.54
Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther (2005) 1.49
Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res (2004) 1.45
The use of frozen cadaveric allografts in the management of patients with bone tumors of the extremities. Orthop Clin North Am (1987) 1.44
A novel murine segmental femoral graft model. J Orthop Res (2004) 1.43
The science of fracture healing. J Orthop Trauma (2006) 1.41
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng (2007) 1.41
Evaluation of canine cortical bone graft remodeling. Vet Surg (1993) 1.40
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther (2000) 1.39
Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther (2005) 1.35
Human reporter genes: potential use in clinical studies. Nucl Med Biol (2007) 1.33
Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg Am (2006) 1.32
Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med (2001) 1.30
Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells. J Orthop Res (2008) 1.24
Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. J Biomech (2007) 1.23
Critical biological determinants of incorporation of non-vascularized cortical bone grafts. Quantification of a complex process and structure. J Bone Joint Surg Am (1997) 1.19
Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system. Mol Ther (2004) 1.17
Ultrasound-based nonviral gene delivery induces bone formation in vivo. Gene Ther (2007) 1.14
Transplantation of bone. Surg Clin North Am (1978) 1.12
Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells. Tissue Eng Part A (2008) 1.11
Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med (2003) 1.08
Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther (2007) 1.07
AAV vectors, insertional mutagenesis, and cancer. Mol Ther (2007) 1.03
Maxillofacial-derived stem cells regenerate critical mandibular bone defect. Tissue Eng Part A (2008) 1.00
Gene transfer approaches to the healing of bone and cartilage. Mol Ther (2002) 1.00
Bone morphogenic protein-2 gene therapy for mandibular distraction osteogenesis. Ann Plast Surg (2004) 0.99
Bone regeneration by modified gene-activated matrix: effectiveness in segmental tibial defects in rats. Tissue Eng (2006) 0.98
Structural and nanoindentation studies of stem cell-based tissue-engineered bone. J Biomech (2006) 0.98
Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep. Hum Gene Ther (2006) 0.97
Effect of BMP-2 gene transfer on bone healing in sheep. Gene Ther (2006) 0.97
Recent advances in gene delivery for structural bone allografts. Tissue Eng (2007) 0.97
The biology of bone grafts. Semin Arthroplasty (1993) 0.97
Molecular imaging of the skeleton: quantitative real-time bioluminescence monitoring gene expression in bone repair and development. J Bone Miner Res (2003) 0.96
Combat orthopaedics: a view from the trenches. J Am Acad Orthop Surg (2006) 0.95
Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose. Hum Gene Ther (2007) 0.92
Specimen-specific beam models for fast and accurate prediction of human trabecular bone mechanical properties. Bone (2006) 0.91
Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model. J Orthop Res (2004) 0.91
Fresh autogeneic, frozen allogeneic, and decalcified allogeneic bone grafts in dogs. J Bone Joint Surg Br (1991) 0.90
Orthopaedic war injuries: from combat casualty care to definitive treatment: a current review of clinical advances, basic science, and research opportunities. Instr Course Lect (2008) 0.89
Freeze-dried allogeneic segmental cortical-bone grafts in dogs. J Bone Joint Surg Am (1978) 0.89
Bone regeneration after topical BMP-2-gene delivery in circumferential peri-implant bone defects. Clin Oral Implants Res (2008) 0.86
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings. Biomaterials (2008) 0.85
Ectopic bone formation by electroporatic transfer of bone morphogenetic protein-4 gene. Bone (2002) 0.84
Ectopic bone formation by human bone morphogenetic protein-2 gene transfer to skeletal muscle using transcutaneous electroporation. Hum Gene Ther (2003) 0.84
Osteoinduction by microbubble-enhanced transcutaneous sonoporation of human bone morphogenetic protein-2. J Gene Med (2009) 0.83
Osteoinduction by bone morphogenetic protein 2-expressing adenoviral vector: application of biomaterial to mask the host immune response. Hum Gene Ther (2004) 0.83
Segmental bone grafting. Comparison of different types of graft in dogs. Int Orthop (1989) 0.82
Bioluminescent imaging in bone. Methods Mol Biol (2008) 0.82
Gene expression analysis of ectopic bone formation induced by electroporatic gene transfer of BMP4. Ups J Med Sci (2006) 0.81
Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression. BMC Musculoskelet Disord (2006) 0.81
Human BMP-2 gene transfer using transcutaneous in vivo electroporation induced both intramembranous and endochondral ossification. Anat Rec A Discov Mol Cell Evol Biol (2005) 0.81
Massive bone allografts for traumatic skeletal defects. South Med J (1991) 0.80
Experimental model for allograft incorporation and allograft fracture repair. J Orthop Res (2000) 0.80
Methods of optimization of electrical impedance tomography for imaging tissue electroporation. Physiol Meas (2007) 0.79
Leukemia inhibitory factor enhances bone formation in calvarial bone defect. J Craniofac Surg (2000) 0.78
Osteogenic enhancement of diaphyseal reconstruction. Comparison of bone grafts in the rabbit. Acta Orthop Scand (1990) 0.76
Feline model for the study of frozen osteoarticular hemijoint transplantation: qualitative and quantitative assessment of bone healing. Am J Vet Res (1985) 0.76
Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood (2004) 4.04
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest (2002) 3.29
Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest (2003) 3.14
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun (2002) 2.44
Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone (2005) 2.26
Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation. J Orthop Res (2008) 2.25
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem (2007) 2.22
Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene (2006) 2.16
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med (2005) 2.10
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res (2005) 2.04
Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum (2011) 1.98
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem (2005) 1.96
Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum (2004) 1.94
Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy. J Immunol (2010) 1.94
COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res (2002) 1.84
RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. J Bone Miner Res (2004) 1.83
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood (2003) 1.78
Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem (2006) 1.73
Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J Clin Invest (2006) 1.69
Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. Arthritis Rheum (2007) 1.68
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci (2008) 1.67
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res (2003) 1.66
Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976) (2007) 1.60
Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev (2005) 1.57
Increased lymphangiogenesis in joints of mice with inflammatory arthritis. Arthritis Res Ther (2007) 1.57
A perspective: engineering periosteum for structural bone graft healing. Clin Orthop Relat Res (2008) 1.57
Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis Rheum (2009) 1.54
Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther (2005) 1.49
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J Cell Physiol (2006) 1.46
The TNF-alpha transgenic mouse model of inflammatory arthritis. Springer Semin Immunopathol (2003) 1.44
A novel murine segmental femoral graft model. J Orthop Res (2004) 1.43
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem (2008) 1.41
MRI and quantification of draining lymph node function in inflammatory arthritis. Ann N Y Acad Sci (2007) 1.41
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng (2007) 1.41
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res (2005) 1.39
Evaluating postoperative analgesics in mice using telemetry. Comp Med (2005) 1.32
Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum (2008) 1.31
Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res (2009) 1.31
TNF-alpha and pathologic bone resorption. Keio J Med (2005) 1.31
NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res (2003) 1.30
Near-infrared lymphatic imaging demonstrates the dynamics of lymph flow and lymphangiogenesis during the acute versus chronic phases of arthritis in mice. Arthritis Rheum (2010) 1.30
Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells. Stem Cells (2006) 1.30
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J Am Soc Nephrol (2005) 1.30
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci (2009) 1.29
Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J Orthop Res (2008) 1.28
Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease. Curr Opin Rheumatol (2006) 1.27
Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol (2008) 1.27
Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction. J Orthop Res (2008) 1.25
Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J Bone Miner Res (2005) 1.24
Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells. J Orthop Res (2008) 1.24
Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. J Biomech (2007) 1.23
Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells. Stem Cells (2004) 1.23
Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration. Tissue Eng (2006) 1.23
Articular cartilage biology. J Am Acad Orthop Surg (2003) 1.22
Circadian oscillation of gene expression in murine calvarial bone. J Bone Miner Res (2007) 1.20
Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. Am J Pathol (2009) 1.20
Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem (2003) 1.20
Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol (2005) 1.20
Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther (2002) 1.19
VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism. J Biol Chem (2008) 1.19
Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res (2012) 1.19
Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. J Cell Biochem (2005) 1.18
Molecular targets for tendon neoformation. J Clin Invest (2008) 1.18
Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Res (2001) 1.18
Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem (2006) 1.17
CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis. Arthritis Res Ther (2010) 1.17
In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res (2002) 1.17
Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther (2008) 1.17
Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system. Mol Ther (2004) 1.17
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem (2008) 1.16
Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse model. Cancer Res (2002) 1.16
Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem (2008) 1.16
CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice. Arthritis Res Ther (2011) 1.15
Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. J Orthop Res (2009) 1.14
Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging. Arthritis Rheum (2008) 1.14
Osteolysis: medical and surgical approaches. Clin Orthop Relat Res (2004) 1.14
Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem Cells (2011) 1.14
RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens. J Cell Physiol (2010) 1.13
Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion. Stem Cells (2008) 1.13