PubRank

Charles S Craik

Author PubWeight™ 121.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Global landscape of HIV-human protein complexes. Nature 2011 3.70
2 Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature 2011 2.71
3 Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell 2010 2.19
4 Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem 2006 2.05
5 Trapping moving targets with small molecules. Science 2009 1.86
6 Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host Microbe 2010 1.76
7 Engineering of a macromolecular scaffold to develop specific protease inhibitors. Nat Biotechnol 2003 1.73
8 Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 2005 1.68
9 Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proc Natl Acad Sci U S A 2007 1.52
10 Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J 2005 1.51
11 Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J 2006 1.42
12 A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem 2004 1.41
13 Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. J Biol Chem 2006 1.31
14 Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem J 2003 1.29
15 Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. J Org Chem 2002 1.26
16 Fabs enable single particle cryoEM studies of small proteins. Structure 2012 1.25
17 Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proc Natl Acad Sci U S A 2009 1.25
18 Methyl groups as probes for proteins and complexes in in-cell NMR experiments. J Am Chem Soc 2004 1.23
19 Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem 2002 1.22
20 Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction. J Am Chem Soc 2003 1.21
21 Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol 2009 1.21
22 Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem 2007 1.19
23 Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem 2009 1.18
24 Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. J Virol 2002 1.17
25 Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces. J Am Chem Soc 2006 1.17
26 Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. J Biol Chem 2006 1.16
27 Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods 2012 1.14
28 Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies. Biochemistry 2003 1.12
29 Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Chem Biol 2005 1.12
30 Quantitative identification of the protonation state of histidines in vitro and in vivo. Biochemistry 2003 1.11
31 Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity. Biochemistry 2002 1.10
32 The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). J Mol Biol 2007 1.10
33 Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. J Mol Biol 2008 1.09
34 A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem 2008 1.06
35 The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J 2004 1.05
36 Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. J Biol Chem 2010 1.04
37 The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol 2003 1.04
38 Prediction of protease substrates using sequence and structure features. Bioinformatics 2010 1.04
39 Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proc Natl Acad Sci U S A 2004 1.03
40 GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data. BMC Bioinformatics 2011 1.03
41 A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem 2010 1.03
42 Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One 2009 1.02
43 Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem J 2002 1.02
44 IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol 2007 1.01
45 Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One 2013 1.00
46 Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate 2005 0.99
47 Papa's got a brand new tag: advances in identification of proteases and their substrates. Trends Biotechnol 2005 0.99
48 Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. Biol Chem 2008 0.99
49 Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorg Med Chem 2005 0.98
50 Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biol Chem 2003 0.98
51 Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. J Biol Chem 2004 0.98
52 Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. J Biol Chem 2013 0.97
53 Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. J Biol Chem 2014 0.97
54 MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov 2013 0.96
55 Induced structure of a helical switch as a mechanism to regulate enzymatic activity. Nat Struct Mol Biol 2005 0.96
56 MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Front Biosci 2008 0.96
57 Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem 2008 0.95
58 Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry 2002 0.93
59 The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Proc Natl Acad Sci U S A 2003 0.92
60 Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol 2002 0.92
61 Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem 2009 0.92
62 Tumor detection by imaging proteolytic activity. Cancer Res 2010 0.92
63 Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J 2004 0.92
64 The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. Int J Parasitol 2008 0.92
65 Conformational change coupling the dimerization and activation of KSHV protease. Biochemistry 2002 0.92
66 How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol 2010 0.92
67 Herpesvirus protease inhibition by dimer disruption. J Virol 2004 0.92
68 Rapid identification of recombinant Fabs that bind to membrane proteins. Methods 2011 0.92
69 A reverse binding motif that contributes to specific protease inhibition by antibodies. J Mol Biol 2011 0.91
70 Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. J Biol Chem 2008 0.91
71 Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res 2013 0.91
72 Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorg Med Chem Lett 2002 0.90
73 Positional scanning synthetic combinatorial libraries for substrate profiling. Methods Mol Biol 2009 0.90
74 Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS Nano 2010 0.90
75 Improving the species cross-reactivity of an antibody using computational design. Bioorg Med Chem Lett 2009 0.90
76 Substrate modulation of enzyme activity in the herpesvirus protease family. J Mol Biol 2007 0.90
77 The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem 2010 0.89
78 SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis 2009 0.89
79 Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem 2004 0.88
80 Mechanisms of macromolecular protease inhibitors. Chembiochem 2010 0.87
81 One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease. Biochemistry 2006 0.87
82 Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer. Biol Chem 2010 0.87
83 Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors 2010 0.87
84 Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. J Biol Chem 2003 0.86
85 Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis 2010 0.86
86 Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A 2012 0.86
87 Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem 2012 0.86
88 Conversion of trypsin to a functional threonine protease. Protein Sci 2006 0.85
89 Hip is a pro-survival substrate of granzyme B. J Biol Chem 2007 0.85
90 Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2012 0.85
91 Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano 2014 0.84
92 Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis 2012 0.84
93 Human and mouse granzyme M display divergent and species-specific substrate specificities. Biochem J 2011 0.84
94 Using specificity to strategically target proteases. Bioorg Med Chem 2008 0.84
95 IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol 2011 0.84
96 Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis 2013 0.83
97 Enzyme inhibition by allosteric capture of an inactive conformation. J Mol Biol 2011 0.83
98 Substrate specificity of transthyretin: identification of natural substrates in the nervous system. Biochem J 2009 0.83
99 Expression and characterization of constitutively active human caspase-14. Biochem Biophys Res Commun 2006 0.82
100 Optimization of 13C direct detection NMR methods. J Biomol NMR 2004 0.82
101 Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. Chem Biol 2011 0.81
102 Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction. Biochemistry 2002 0.81
103 Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Res 2011 0.81
104 Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry 2014 0.80
105 Design and synthesis of novel inhibitors of gelatinase B. Bioorg Med Chem Lett 2002 0.78
106 Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem 2002 0.78
107 Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. Nano Lett 2008 0.78
108 Elastin degradation by cathepsin V requires two exosites. J Biol Chem 2013 0.77
109 Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry 2012 0.77
110 Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference. Biochimie 2012 0.77
111 Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology 2009 0.77
112 Engineering ecotin for identifying proteins with a trypsin fold. Appl Biochem Biotechnol 2009 0.76
113 Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation. Biol Chem 2010 0.76
114 Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis. Arch Biochem Biophys 2008 0.76
115 Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis. Prostate 2011 0.76
116 Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem 2013 0.75
117 Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors. Biol Chem 2016 0.75
118 Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost 2017 0.75
119 Imaging PD-L1 expression with immunoPET. Bioconjug Chem 2017 0.75