PubRank

Jung Joon Lee

Author PubWeight™ 59.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol 2006 1.91
2 Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res 2003 1.45
3 Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. Carcinogenesis 2008 1.27
4 Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production. J Nat Prod 2002 1.18
5 Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. Cancer Res 2010 1.17
6 Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett 2007 1.12
7 (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J Med Chem 2007 1.10
8 An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem 2010 1.03
9 Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes. J Biol Chem 2002 1.01
10 Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. J Pharmacol Exp Ther 2005 0.95
11 Rational biosynthetic engineering for optimization of geldanamycin analogues. Chembiochem 2009 0.94
12 Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin. J Am Chem Soc 2004 0.93
13 Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species. J Nat Prod 2009 0.92
14 Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis. PLoS One 2012 0.91
15 Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. J Nat Prod 2006 0.91
16 The first total synthesis of moracin O and moracin P, and establishment of the absolute configuration of moracin O. Chem Commun (Camb) 2009 0.91
17 Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression. J Nat Prod 2008 0.89
18 Cucurbitacin B suppresses the transactivation activity of RelA/p65. J Cell Biochem 2011 0.89
19 A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway. Biochem Biophys Res Commun 2009 0.88
20 Angiogenic activity of sesamin through the activation of multiple signal pathways. Biochem Biophys Res Commun 2009 0.87
21 Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharm Res 2006 0.86
22 A novel dihydroxanthenone, AGI-B4 with inhibition of VEGF-induced endothelial cell growth. J Antibiot (Tokyo) 2002 0.86
23 Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med 2012 0.86
24 Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring. Chembiochem 2007 0.86
25 Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int Immunopharmacol 2008 0.85
26 Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB. Phytochemistry 2003 0.85
27 Caesaldecan, a cassane diterpenoid from the leaves of Caesalpinia decapetala. Chem Pharm Bull (Tokyo) 2005 0.85
28 Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety. Chembiochem 2006 0.85
29 Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1. J Nat Prod 2007 0.85
30 Diarylheptanoids from Alnus hirsuta inhibit the NF-kB activation and NO and TNF-alpha production. Biol Pharm Bull 2007 0.84
31 Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Planta Med 2002 0.83
32 The sesquiterpene lactone eupatolide sensitizes breast cancer cells to TRAIL through down-regulation of c-FLIP expression. Oncol Rep 2010 0.83
33 A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Biol Pharm Bull 2008 0.83
34 Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB. Planta Med 2003 0.82
35 Inhibitors of the LPS-induced NF-kappaB activation from Artemisia sylvatica. Phytochemistry 2004 0.82
36 Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway. Biochem Biophys Res Commun 2010 0.82
37 A quassinoid 6alpha-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation. Eur J Pharmacol 2008 0.82
38 Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. J Pharmacol Sci 2010 0.82
39 Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett 2010 0.81
40 Cytotoxic prenylated flavonoids from Morus alba. Fitoterapia 2010 0.81
41 4′,6-dihydroxy-4-methoxyisoaurone inhibits the HIF-1α pathway through inhibition of Akt/mTOR/p70S6K/4E-BP1 phosphorylation. J Pharmacol Sci 2014 0.81
42 Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. J Antibiot (Tokyo) 2002 0.80
43 Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus. Planta Med 2004 0.80
44 Hypoxia-inducible factor-1 and nuclear factor-kappaB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia. Bioorg Med Chem Lett 2008 0.80
45 New sesquiterpene dimers from Inula britannica inhibit NF-kappaB activation and NO and TNF-alpha production in LPS-stimulated RAW264.7 cells. Planta Med 2006 0.80
46 Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma. J Nat Prod 2002 0.79
47 Lupane-triterpene carboxylic acids from the leaves of Acanthopanax trifoliatus. Chem Pharm Bull (Tokyo) 2003 0.79
48 In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents. Biol Pharm Bull 2007 0.79
49 A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata. Planta Med 2009 0.79
50 Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo. Planta Med 2004 0.79
51 Lupane-triterpenes from the leaves of Brassaiopsis glomerulata. Arch Pharm Res 2003 0.78
52 Four ent-kaurane-type diterpenoids from Croton tonkinensis Gagnep. Chem Pharm Bull (Tokyo) 2004 0.78
53 Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. Eur J Pharmacol 2010 0.78
54 An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB. J Nat Prod 2010 0.78
55 Effect of 5-O-Methylhirsutanonol on nuclear factor-kappaB-dependent production of NO and expression of iNOS in lipopolysaccharide-induced RAW264.7 cells. J Agric Food Chem 2007 0.78
56 Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res 2007 0.78
57 Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol 2004 0.78
58 Pentacyclic triterpenoids from Mallotus apelta. Arch Pharm Res 2004 0.77
59 Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis. Biochem Pharmacol 2003 0.77
60 Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch Pharm Res 2008 0.77
61 Triterpenoids and diarylheptanoids from Alnus hirsuta inhibit HIF-1 in AGS cells. Arch Pharm Res 2007 0.77
62 Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa. Biol Pharm Bull 2004 0.77
63 6-Alkylsalicylic acid analogues inhibit in vitro ATPase activity of heat shock protein 90. Arch Pharm Res 2010 0.77
64 Two new phenylpropanoid glycosides from the stem bark of Acanthopanax trifoliatus. Arch Pharm Res 2003 0.77
65 Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis. Arch Pharm Res 2005 0.77
66 Pharmacophore-based 3D-QSAR of HIF-1 inhibitors. Arch Pharm Res 2009 0.77
67 Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-kappaB activation and NO production in macrophage RAW264.7 cells. J Nat Prod 2007 0.76
68 Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma. J Antibiot (Tokyo) 2005 0.76
69 Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription. Arch Pharm Res 2004 0.75
70 Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. Planta Med 2003 0.75
71 Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427. J Microbiol Biotechnol 2010 0.75
72 A new 24-nor-lupane-glycoside of Acanthopanax trifoliatus. Arch Pharm Res 2003 0.75
73 Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum. Chem Pharm Bull (Tokyo) 2003 0.75
74 Wilfoside K1N isolated from Cynanchum wilfordii inhibits angiogenesis and tumor cell invasion. Int J Oncol 2005 0.75
75 Synthesis of 4-acetylisocoumarin: first total syntheses of AGI-7 and sescandelin. J Org Chem 2002 0.75
76 Pharmacokinetics of 11-hydroxyaclacinomycin X (ID-6105), a novel anthracycline, after i.v. bolus multiple administration in rats. Arch Pharm Res 2005 0.75
77 ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-kappaB activation and NO production. J Nat Prod 2003 0.75
78 A new phenyl glycoside from the aerial parts of Equisetum hyemale. Nat Prod Res 2014 0.75
79 Inhibition of NF-IL6 activity by manassantin B, a dilignan isolated from Saururus chinensis, in phorbol myristate acetate-stimulated U937 promonocytic cells. Mol Cells 2005 0.75
80 New cytotoxic benzopyrans from the leaves of Mallotus apelta. Arch Pharm Res 2005 0.75
81 Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice. Arch Pharm Res 2010 0.75
82 Apoptosis induced by ID6105, a new anthracycline (11-hydroxyaclacinomycin X, Hyrubicin), and its anti-tumor effects on experimental tumor models. Cancer Chemother Pharmacol 2006 0.75
83 Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci 2012 0.75
84 In vivo antitumor efficacy and cardiotoxicity of novel anthracycline ID6105 (11-hydroxy-aclacinomycin X, Hyrubicin). Cancer Chemother Pharmacol 2005 0.75
85 Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-alpha secretion from trypsin-stimulated HMC-1 cells. Arch Pharm Res 2003 0.75