PubRank

D W Crabb

Author PubWeight™ 71.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991 2.75
2 Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol. Alcohol 2006 1.75
3 A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells. Anal Biochem 1987 1.59
4 Alcohol and medication interactions. Alcohol Res Health 1999 1.58
5 Training resident physicians in fiberoptic sigmoidoscopy. How many supervised examinations are required to achieve competence? Am J Med 1986 1.50
6 Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. J Biol Chem 1993 1.45
7 Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 1994 1.38
8 Evidence for both a regulatory mutation and a structural mutation in a family with maple syrup urine disease. J Clin Invest 1989 1.32
9 The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J Biol Chem 2001 1.30
10 The metabolic effects of dichloroacetate. Metabolism 1981 1.29
11 An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength. Alcohol Clin Exp Res 1999 1.29
12 cDNA cloning of the E1 alpha subunit of the branched-chain alpha-keto acid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Ann N Y Acad Sci 1989 1.28
13 Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 2001 1.25
14 A new family of protein kinases--the mitochondrial protein kinases. Adv Enzyme Regul 1995 1.24
15 Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 1993 1.17
16 Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 1996 1.16
17 Familial gastroesophageal reflux and development of Barrett's esophagus. Ann Intern Med 1985 1.16
18 Molecular cloning of a cDNA for the E1 alpha subunit of rat liver branched chain alpha-ketoacid dehydrogenase. J Biol Chem 1987 1.14
19 Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms. Gut 2004 1.12
20 Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. Hepatology 1991 1.09
21 Regulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Adv Enzyme Regul 1990 1.07
22 The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest 1995 1.06
23 CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution. J Biol Chem 1992 1.04
24 The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 1996 1.03
25 Alcoholic liver disease. Curr Opin Gastroenterol 2000 1.02
26 Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver. J Biol Chem 1988 0.99
27 Nucleotide and deduced amino acid sequence of the E1 alpha subunit of human liver branched-chain alpha-ketoacid dehydrogenase. Gene 1988 0.97
28 Premature translation termination of the pre-E1 alpha subunit of the branched chain alpha-ketoacid dehydrogenase as a cause of maple syrup urine disease in Polled Hereford calves. J Biol Chem 1990 0.96
29 Structural and mechanistic similarities of 6-phosphogluconate and 3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the 3-hydroxyacid dehydrogenases. FEBS Lett 1996 0.95
30 Alcoholic liver disease. Curr Opin Gastroenterol 2001 0.94
31 Steady-state kinetic properties of purified rat liver alcohol dehydrogenase: application to predicting alcohol elimination rates in vivo. Arch Biochem Biophys 1983 0.93
32 Site-directed mutagenesis of phosphorylation sites of the branched chain alpha-ketoacid dehydrogenase complex. J Biol Chem 1994 0.92
33 The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 1995 0.91
34 Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis. Hepatology 1993 0.91
35 Relationship between kinetics of liver alcohol dehydrogenase and alcohol metabolism. Pharmacol Biochem Behav 1983 0.90
36 Effect of dichloroacetate on carbohydrate and lipid metabolism of isolated hepatocytes. Arch Biochem Biophys 1976 0.90
37 Immunocytochemistry of alcohol dehydrogenase in the rat central nervous system. Alcohol Clin Exp Res 1989 0.88
38 Assaying the reporter gene chloramphenicol acetyltransferase. Methods Enzymol 1989 0.86
39 Molecular defects in the E1 alpha subunit of the branched-chain alpha-ketoacid dehydrogenase complex that cause maple syrup urine disease. Mol Biol Med 1991 0.86
40 Complete amino acid sequence of rat liver alcohol dehydrogenase deduced from the cDNA sequence. Gene 1986 0.85
41 Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. J Biol Chem 1989 0.85
42 CCAAT/enhancer binding protein binds and activates the promoter of the rat class I alcohol dehydrogenase gene. Arch Biochem Biophys 1991 0.84
43 Genetic aspects and risk factors in alcoholism and alcoholic liver disease. Gastroenterology 1994 0.83
44 Sensitivity of virally-driven luciferase reporter plasmids to members of the steroid/thyroid/retinoid family of nuclear receptors. J Steroid Biochem Mol Biol 2000 0.83
45 Studies on the regulation of leucine catabolism in the liver. Stimulation by pyruvate and dichloroacetate. J Biol Chem 1978 0.83
46 Localization of the human gene for the El alpha subunit of branched chain keto acid dehydrogenase (BCKDHA) to chromosome 19q13.1----q13.2. Cytogenet Cell Genet 1989 0.82
47 Mechanism responsible for the hypoglycemic actions of dichloroacetate and 2-chloropropionate. Arch Biochem Biophys 1979 0.81
48 Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone. Arch Biochem Biophys 1988 0.81
49 Inhibition of hepatocyte proteolysis and lactate gluconeogenesis by chloroquine. Arch Biochem Biophys 1980 0.80
50 Chemical modification and site-directed mutagenesis studies of rat 3-hydroxyisobutyrate dehydrogenase. Biochemistry 1995 0.80
51 The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner. Biochem Biophys Res Commun 1993 0.80
52 Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. Biochim Biophys Acta 1998 0.80
53 The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene. Gene 1996 0.79
54 The molecular biology of alcohol dehydrogenase: implications for the control of alcohol metabolism. J Lab Clin Med 1988 0.79
55 Effect of fasting on the activity and turnover of rat liver alcohol dehydrogenase. Alcohol Clin Exp Res 1984 0.79
56 Studies on the regulation of leucine catabolism. II. Mechanism responsible for dichloroacetate stimulation of leucine oxidation by the liver. Arch Biochem Biophys 1978 0.79
57 Molecular cloning of the E1 beta subunit of the rat branched chain alpha-ketoacid dehydrogenase. Biochim Biophys Acta 1992 0.79
58 Inhibition of hepatic gluconeogenesis by dichloroacetate. Arch Biochem Biophys 1978 0.79
59 Sequence of the E1 alpha subunit of branched-chain alpha-ketoacid dehydrogenase in two patients with thiamine-responsive maple syrup urine disease. Am J Hum Genet 1990 0.78
60 Molecular cloning of the branched-chain alpha-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenase. Adv Enzyme Regul 1993 0.78
61 Role of the pituitary and neonatal androgenic imprinting in the hormonal regulation of liver alcohol dehydrogenase activity. Biochem Pharmacol 1986 0.78
62 The heat-shock response in cultured cells exposed to ethanol and its metabolites. J Lab Clin Med 1989 0.77
63 Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression. Hepatology 1994 0.77
64 Effects of vitamin A deficiency on rat liver alcohol dehydrogenase expression and alcohol elimination rate in rats. Alcohol Clin Exp Res 2000 0.77
65 Mammalian 3-hydroxyisobutyrate dehydrogenase. Methods Enzymol 2000 0.77
66 Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney. Hepatology 1993 0.77
67 Expression of alcohol dehydrogenase in primary monolayer cultures of rat hepatocytes. Biochem Biophys Res Commun 1985 0.77
68 Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics. Alcohol Clin Exp Res 1994 0.77
69 Rate-determining factors for ethanol metabolism in fasted and castrated male rats. Biochem Pharmacol 1984 0.77
70 Estradiol induces class I alcohol dehydrogenase activity and mRNA in kidney of female rats. Arch Biochem Biophys 1991 0.76
71 Estradiol regulates class I alcohol dehydrogenase gene expression in renal medulla of male rats by a post-transcriptional mechanism. Arch Biochem Biophys 1992 0.76
72 The effect of experimental diabetes on liver alcohol dehydrogenase activity in rats. Alcohol Clin Exp Res 1986 0.76
73 Catabolism of isobutyrate by colonocytes. Arch Biochem Biophys 1996 0.75
74 A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene. Brain Res Mol Brain Res 1997 0.75
75 Molecular cloning of the E1 beta subunit of the rat branched chain alpha-ketoacid dehydrogenase. Biochim Biophys Acta 1995 0.75
76 Corticosterone induces rat liver alcohol dehydrogenase mRNA but not enzyme protein or activity. Alcohol Clin Exp Res 1992 0.75
77 Studies on the hormonal regulation of rat liver alcohol dehydrogenase. Prog Clin Biol Res 1987 0.75
78 Methylmalonic aciduria presenting in an adult. J Inherit Metab Dis 1991 0.75
79 Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA. Alcohol Clin Exp Res 1991 0.75
80 Tissue-specific expression and preliminary functional analysis of the 5' flanking regions of the human mitochondrial aldehyde dehydrogenase (ALDH2) gene. Adv Exp Med Biol 1995 0.75
81 Detection of a CA repeat polymorphism in the rat class I alcohol dehydrogenase gene. Alcohol Clin Exp Res 1993 0.75
82 Central nervous system control of alcohol dehydrogenase activity in rats. Life Sci 1985 0.75
83 Hormonal control of hepatic lipogenesis. Adv Exp Med Biol 1979 0.75
84 Loss of growth hormone-dependent characteristics of rat hepatocytes in culture. In Vitro Cell Dev Biol 1987 0.75
85 Loss of sexual differentiation of rat hepatocytes in short-term culture. Alcohol Alcohol Suppl 1987 0.75
86 Characterization of the 5'-flanking sequence of rat class I alcohol dehydrogenase gene. J Biol Chem 1994 0.75
87 Modulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo. Adv Exp Med Biol 1993 0.75
88 Genetically determined differences in liver alcohol dehydrogenase activity in male rats. Biochem Genet 1985 0.75
89 The first 22 base pairs of the proximal promoter of the rat class I alcohol dehydrogenase gene is bipartite and interacts with multiple DNA-binding proteins. Arch Biochem Biophys 1992 0.75
90 Structural and mechanistic aspects of a new family of dehydrogenases, the beta-hydroxyacid dehydrogenases. Adv Exp Med Biol 1997 0.75
91 Regulation of the expression of the rat alcohol dehydrogenase gene by glucocorticoids. Prog Clin Biol Res 1989 0.75
92 Alcoholism research: recent developments. Indiana Med 1985 0.75
93 Seven transmembrane domain receptor subtypes identified in NG108-15 cells by reverse transcription-polymerase chain reaction. Biochem Biophys Res Commun 1994 0.75