Published in Am J Hum Genet on April 01, 1991
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health (2007) 3.67
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet (1999) 3.03
Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet (1999) 2.73
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry (2011) 2.45
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Effect of alcohol consumption on risk of hyperhomocysteinemia based on alcohol-related facial flushing response. Korean J Fam Med (2013) 1.52
Evidence of positive selection on a class I ADH locus. Am J Hum Genet (2007) 1.48
Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism. Addict Biol (2006) 1.47
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The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci (2003) 1.44
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Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet (2003) 1.39
Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. Am J Hum Genet (2007) 1.37
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Genetic studies of alcoholism and substance dependence. Am J Hum Genet (1999) 1.17
Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. Alcohol Clin Exp Res (2010) 1.11
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Hum Genet (2011) 1.10
Genes encoding enzymes involved in ethanol metabolism. Alcohol Res (2012) 1.09
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Hum Genet (2013) 1.06
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Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Hum Genet (2013) 1.04
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Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. J Stud Alcohol Drugs (2008) 1.03
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Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. Genes (Basel) (2014) 1.01
Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. World J Gastroenterol (2005) 1.01
Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. Clin Psychol Sci (2015) 1.00
Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. Hum Genet (2012) 0.99
Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males. World J Gastroenterol (2008) 0.99
Convergence of genome-wide association and candidate gene studies for alcoholism. Alcohol Clin Exp Res (2012) 0.96
Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample. Alcohol Clin Exp Res (2011) 0.95
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. FASEB J (2009) 0.94
Association between alcoholism and the dopamine D4 receptor gene. J Med Genet (1996) 0.91
Cancer stem cells in head and neck cancer. Onco Targets Ther (2012) 0.90
Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. J Neurogenet (2009) 0.88
ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. Alcohol Clin Exp Res (2011) 0.86
Identifying genetic variation for alcohol dependence. Alcohol Res (2012) 0.86
Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. Philos Trans R Soc Lond B Biol Sci (2008) 0.86
Alcohol metabolism in human cells causes DNA damage and activates the Fanconi anemia-breast cancer susceptibility (FA-BRCA) DNA damage response network. Alcohol Clin Exp Res (2011) 0.86
A new approach to SNP genotyping with fluorescently labeled mononucleotides. Nucleic Acids Res (2004) 0.85
Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. Hum Genomics (2009) 0.85
Genetic research: who is at risk for alcoholism. Alcohol Res Health (2010) 0.85
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. Alcohol Clin Exp Res (2015) 0.85
Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome. J Cell Mol Med (2011) 0.84
Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample. Alcohol Clin Exp Res (2013) 0.84
Genetic predisposition to alcoholic liver disease. Gut (1992) 0.84
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis. Proc Natl Acad Sci U S A (2015) 0.82
Gene specific modifications unravel ethanol and acetaldehyde actions. Front Behav Neurosci (2013) 0.82
Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol (2015) 0.82
A FRET-based analysis of SNPs without fluorescent probes. Nucleic Acids Res (2004) 0.82
Variation in the ADH1B proximal promoter affects expression. Chem Biol Interact (2010) 0.82
Advances in genetic studies of substance abuse in China. Shanghai Arch Psychiatry (2013) 0.81
Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk. PLoS One (2014) 0.81
Genetically selected alcohol preferring rats to model human alcoholism. Curr Top Behav Neurosci (2013) 0.81
Heritability of smoking, alcohol use, and psychological characteristics among adolescent twins in Qingdao, China. Asia Pac J Public Health (2010) 0.80
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. Hum Mol Genet (2010) 0.80
Endophenotypes for Alcohol Use Disorder: An Update on the Field. Curr Addict Rep (2015) 0.80
Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol. J Exp Med (2001) 0.80
Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. Am J Med Genet B Neuropsychiatr Genet (2014) 0.79
Allelic variants of ADH, ALDH and the five factor model of personality in alcohol dependence syndrome. Ind Psychiatry J (2014) 0.79
Genomic influences on alcohol problems in a population-based sample of young adults. Addiction (2015) 0.79
Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer. Alcohol Alcohol (2012) 0.78
Recent advances in understanding the role of nutrition in human genome evolution. Adv Nutr (2011) 0.78
Genetics of bipolar affective disorder: time for another reinvention? Am J Hum Genet (1995) 0.78
Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. J Stud Alcohol Drugs (2014) 0.78
Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls. Chem Biol Interact (2015) 0.78
Anxiety and depression in patients with head and neck cancer: 6-month follow-up study. Neuropsychiatr Dis Treat (2016) 0.78
Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. Dig Dis Sci (2000) 0.78
Gene-Environment Interplay: Where We Are, Where We Are Going. J Marriage Fam (2015) 0.78
ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet (2017) 0.78
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. Alcohol Clin Exp Res (2015) 0.77
ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies. PLoS One (2012) 0.77
Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. Hum Hered (2010) 0.77
Genetics of major mood disorders. Psychiatry (Edgmont) (2004) 0.77
Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? Alcohol Clin Exp Res (2011) 0.76
Pharmacotherapy for alcohol use disorder: current and emerging therapies. Harv Rev Psychiatry (2015) 0.76
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis. Yonsei Med J (2016) 0.76
Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? Addict Biol (2015) 0.76
Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. Int J Clin Exp Med (2015) 0.76
Establishment of a Quick and Highly Accurate Breath Test for ALDH2 Genotyping. Clin Transl Gastroenterol (2017) 0.75
Genetics of addictions. Clin Lab Med (2010) 0.75
The complexity of complex diseases. Am J Hum Genet (2003) 0.75
The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review. Am J Transl Res (2010) 0.75
Habitual Alcohol Consumption and Metabolic Syndrome in Patients with Sleep Disordered Breathing. PLoS One (2016) 0.75
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An experimental approach to understanding the genetic and neurobiological basis of alcoholism. Trans Am Clin Climatol Assoc (1993) 0.75
Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. PLoS One (2017) 0.75
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol Psychiatry (2017) 0.75
Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA (1990) 5.04
Cellular and molecular mechanisms of drug dependence. Science (1988) 4.99
DNA banking: the effects of storage of blood and isolated DNA on the integrity of DNA. Am J Med Genet (1987) 4.09
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A (1984) 3.22
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Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest (1989) 2.44
Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology (1986) 2.20
Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis. Lancet (1984) 2.09
Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet (1979) 2.01
Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. Am J Hum Genet (1980) 1.97
Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: gene deletion and its possible implications in alcohol metabolism. Biochem Genet (1981) 1.76
Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet (1982) 1.46
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Hybridization of genomic DNA to oligonucleotide probes in the presence of tetramethylammonium chloride. Methods Enzymol (1987) 1.28
Genetics of human alcohol and aldehyde dehydrogenases. Adv Hum Genet (1986) 1.28
Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. Genomics (1988) 1.20
Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. Am J Hum Genet (1988) 1.20
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A twin study of ethanol metabolism. Behav Genet (1985) 1.15
Relationship between facial flushing and blood acetaldehyde levels after alcohol intake. Pharmacol Biochem Behav (1979) 1.12
Aldehyde dehydrogenase polymorphism and alcohol metabolism in alcoholics. Alcohol (1985) 1.10
Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2. Am J Hum Genet (1986) 1.09
Alcohol metabolism in American Indians and whites. Lack of racial differences in metabolic rate and liver alcohol dehydrogenase. N Engl J Med (1976) 1.08
Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots. Hum Genet (1989) 1.07
Determinations of ethanol, acetaldehyde and acetate in blood and urine during alcohol oxidation in man. Alcohol Alcohol (1989) 1.06
The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. Genomics (1990) 1.06
Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers. Hum Genet (1989) 1.05
The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects. Eur J Clin Pharmacol (1977) 1.04
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Aldehyde dehydrogenase isozyme variation and alcoholism in Japan. Pharmacol Biochem Behav (1983) 1.02
Human alcohol dehydrogenase ADH2 and ADH3 polymorphisms in ethnic Chinese and Indians of West Malaysia. Hum Genet (1979) 0.90
Lung alcohol and aldehyde dehydrogenase isoenzymes in Chinese. Taiwan Yi Xue Hui Za Zhi (1989) 0.87
Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization. Genomics (1989) 0.84
Polymorphism of aldehyde dehydrogenase and ethanol elimination. Alcohol (1985) 0.83
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A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N Engl J Med (1986) 8.03
A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis (1990) 6.52
Human serology in Chlamydia trachomatis infection with microimmunofluorescence. J Infect Dis (1974) 6.18
Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet (1998) 6.04
Immunotyping of Chlamydia trachomatis with monoclonal antibodies. J Infect Dis (1985) 5.29
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New and emerging etiologies for community-acquired pneumonia with implications for therapy. A prospective multicenter study of 359 cases. Medicine (Baltimore) (1990) 4.04
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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
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Current knowledge on Chlamydia pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases. Eur J Clin Microbiol Infect Dis (1989) 3.15
A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet (2000) 3.14
Identification of a new group of Chlamydia psittaci strains called TWAR. J Clin Microbiol (1986) 3.11
Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol (1998) 3.07
Simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (Chlamydia trachomatis) antigens for use as a screening test for antibody. J Clin Microbiol (1975) 3.03
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet (1999) 3.03
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Pneumonia associated with the TWAR strain of Chlamydia. Ann Intern Med (1987) 3.00
Three new immunologic types of trachoma-inclusion conjunctivitis organisms. J Immunol (1973) 2.96
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Chlamydia pneumoniae (TWAR) in atherosclerosis of the carotid artery. Circulation (1995) 2.24
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TRIC type K, a new immunologic type of Chlamydia trachomatis. J Immunol (1974) 2.22
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Evidence that Chlamydia pneumoniae causes pneumonia and bronchitis. J Infect Dis (1993) 1.89
A potency test for trachoma vaccine utilizing the mouse toxicity prevention test. Am J Ophthalmol (1967) 1.89
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Community- and hospital-acquired pneumonia associated with Chlamydia TWAR infection demonstrated serologically. Arch Intern Med (1989) 1.86
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Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins. Am J Hum Genet (2000) 1.85
The potential for vaccine against infection of the genital tract with Chlamydia trachomatis. Sex Transm Dis (1999) 1.84
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84
Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res (1997) 1.79
Rapid immunotyping of Chlamydia trachomatis with monoclonal antibodies in a solid-phase enzyme immunoassay. J Clin Microbiol (1985) 1.79
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Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry (2008) 1.78
Distal tubal obstruction induced by repeated Chlamydia trachomatis salpingeal infections in pig-tailed macaques. J Infect Dis (1987) 1.76
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Genital infections with Chlamydia trachomatis and Neisseria gonorrhoeae in Ghanaian women. Genitourin Med (1985) 1.73
A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res (2001) 1.72
Countrywide epidemics of Chlamydia pneumoniae, strain TWAR, in Scandinavia, 1981-1983. J Infect Dis (1989) 1.72
Subnuclear systems for synthesis of simian virus 40 DNA in vitro. Proc Natl Acad Sci U S A (1976) 1.71
Sexually transmitted diseases and tubal pregnancy. Sex Transm Dis (1991) 1.69
Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol (1995) 1.67
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res (2001) 1.63
Serological response to Chlamydia pneumoniae in adults with coronary arterial fatty streaks and fibrolipid plaques. J Clin Microbiol (1993) 1.63
Persistent Campylobacter jejuni infection in an immunocompromised patient. Ann Intern Med (1984) 1.62
Detection of multiple serovars of Chlamydia trachomatis in genital infections. J Infect Dis (1985) 1.61
A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells. Anal Biochem (1987) 1.59
Alcohol and medication interactions. Alcohol Res Health (1999) 1.58
Clamping breath alcohol concentration reduces experimental variance: application to the study of acute tolerance to alcohol and alcohol elimination rate. Alcohol Clin Exp Res (1998) 1.58
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Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet (2007) 1.55
Relation between diurnal variation of blood pressure and left ventricular mass in a Chinese population. Am J Cardiol (1995) 1.55
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