Published in Antimicrob Agents Chemother on January 01, 1991
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrob Agents Chemother (1994) 4.43
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC. Antimicrob Agents Chemother (2004) 2.10
Reevaluation of the factors involved in the efficacy of new beta-lactams against Enterobacter cloacae. Antimicrob Agents Chemother (1991) 1.16
Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa SC8329. Antimicrob Agents Chemother (1991) 1.13
Molecular basis of the efficacy of cefaclor against Haemophilus influenzae. Antimicrob Agents Chemother (1992) 0.86
Method for estimation of low outer membrane permeability to beta-lactam antibiotics. Antimicrob Agents Chemother (2002) 0.78
Evaluation of several dosing regimens of cefepime, with various simulations of renal function, against clinical isolates of Pseudomonas aeruginosa in a pharmacodynamic infection model. Antimicrob Agents Chemother (1999) 0.77
Comparison of strategies using cefpirome and ceftazidime for empiric treatment of pneumonia in intensive care patients. The Cefpirome Pneumonia Study Group. Antimicrob Agents Chemother (1998) 0.75
Molecular basis of bacterial outer membrane permeability. Microbiol Rev (1985) 17.75
Periplasmic space in Salmonella typhimurium and Escherichia coli. J Biol Chem (1977) 8.13
Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics. Antimicrob Agents Chemother (1977) 7.70
Outer membrane of Salmonella typhimurium: chemical analysis and freeze-fracture studies with lipopolysaccharide mutants. J Bacteriol (1975) 6.51
Porin channels in Escherichia coli: studies with beta-lactams in intact cells. J Bacteriol (1983) 6.29
Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins. J Bacteriol (1983) 5.20
Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12. Antimicrob Agents Chemother (1985) 4.88
Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams. Antimicrob Agents Chemother (1985) 4.43
Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture. J Gen Microbiol (1983) 3.41
The interplay of beta-lactamases and intrinsic factors in the resistance of gram-negative bacteria to penicillins and cephalosporins. Ann N Y Acad Sci (1974) 2.83
Structure and function of porins from gram-negative bacteria. Annu Rev Microbiol (1988) 2.60
Role of permeability barriers in resistance to beta-lactam antibiotics. Pharmacol Ther (1985) 2.32
Antibiotic uptake into gram-negative bacteria. Eur J Clin Microbiol Infect Dis (1988) 2.30
Role of porins in outer membrane permeability. J Bacteriol (1987) 2.06
Outer membrane permeability and beta-lactamase stability of dipolar ionic cephalosporins containing methoxyimino substituents. Antimicrob Agents Chemother (1990) 2.03
Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. J Biol Chem (1988) 1.77
A method for measuring the outer membrane-permeability of beta-lactam antibiotics in gram-negative bacteria. J Antibiot (Tokyo) (1977) 1.69
Contribution of beta-lactamase hydrolysis and outer membrane permeability to ceftriaxone resistance in Enterobacter cloacae. Antimicrob Agents Chemother (1987) 1.55
Effect of EDTA upon bacterial permeability to benzylpenicillin. Biochem Biophys Res Commun (1965) 1.33
Reevaluation of the factors involved in the efficacy of new beta-lactams against Enterobacter cloacae. Antimicrob Agents Chemother (1991) 1.16
The permeability parameter of the outer membrane of Pseudomonas aeruginosa varies with the concentration of a test substrate, cephalosporin C. J Gen Microbiol (1986) 1.16
Molecular characterization of an Enterobacter cloacae gene (romA) which pleiotropically inhibits the expression of Escherichia coli outer membrane proteins. J Bacteriol (1990) 1.10
A novel method for evaluating the outer membrane permeability to beta-lactamase-stable beta-lactam antibiotics. J Antibiot (Tokyo) (1980) 0.94
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature (2000) 32.30
Outer membrane of Pseudomonas aeruginosa: heat- 2-mercaptoethanol-modifiable proteins. J Bacteriol (1979) 9.28
Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains. J Bacteriol (1983) 8.19
Outer membranes of gram-negative bacteria. XIX. Isolation from Pseudomonas aeruginosa PAO1 and use in reconstitution and definition of the permeability barrier. J Bacteriol (1978) 7.66
Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect Immun (1983) 6.24
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol Microbiol (1997) 5.91
Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob Agents Chemother (1982) 4.98
Outer membrane protein H1 of Pseudomonas aeruginosa: involvement in adaptive and mutational resistance to ethylenediaminetetraacetate, polymyxin B, and gentamicin. J Bacteriol (1980) 4.93
Con--mutants: class of mutants in Escherichia coli K-12 lacking a major cell wall protein and defective in conjugation and adsorption of a bacteriophage. J Bacteriol (1974) 4.63
Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili. J Bacteriol (2000) 4.59
Iron transport of Escherichia coli K-12: involvement of the colicin B receptor and of a citrate-inducible protein. J Bacteriol (1976) 4.35
Alterations in outer membrane permeability. Annu Rev Microbiol (1984) 4.22
Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1981) 3.95
Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Biochemistry (1999) 3.88
Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01. Biochim Biophys Acta (1979) 3.70
Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes. Biochim Biophys Acta (1981) 3.65
Functional organization of the outer membrane of escherichia coli: phage and colicin receptors as components of iron uptake systems. J Supramol Struct (1976) 3.53
Use of the fluorescent probe 1-N-phenylnaphthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1984) 3.19
Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families. Infect Immun (2000) 3.13
Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane. J Biol Chem (1999) 3.07
Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Antimicrob Agents Chemother (2000) 3.06
Pseudomonas aeruginosa outer membrane permeability: isolation of a porin protein F-deficient mutant. J Bacteriol (1983) 2.98
Bacteriophage resistance in Escherichia coli K-12: general pattern of resistance. J Bacteriol (1975) 2.94
Ion selectivity of gram-negative bacterial porins. J Bacteriol (1985) 2.87
Aminoglycoside uptake and mode of action--with special reference to streptomycin and gentamicin. I. Antagonists and mutants. J Antimicrob Chemother (1981) 2.78
Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin. Antimicrob Agents Chemother (1986) 2.74
Outer membrane protein P of Pseudomonas aeruginosa: regulation by phosphate deficiency and formation of small anion-specific channels in lipid bilayer membranes. J Bacteriol (1982) 2.73
Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1982) 2.64
Iron transport in Escherichia coli K-12. 2,3-Dihydroxybenzoate-promoted iron uptake. Arch Microbiol (1977) 2.62
Monoclonal antibodies against Pseudomonas aeruginosa outer membrane antigens: isolation and characterization. Infect Immun (1982) 2.61
Mode of action of the antimicrobial peptide indolicidin. J Biol Chem (1996) 2.57
Surface localization of Pseudomonas aeruginosa outer membrane porin protein F by using monoclonal antibodies. Infect Immun (1983) 2.51
Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane. Antimicrob Agents Chemother (1984) 2.37
Heterogeneity of lipopolysaccharides from Pseudomonas aeruginosa: analysis of lipopolysaccharide chain length. J Bacteriol (1988) 2.35
Outer membrane proteins of Pseudomonas aeruginosa serotype strains. J Infect Dis (1982) 2.32
Determinants of efficacy and toxicity of aminoglycosides. J Antimicrob Chemother (1989) 2.30
Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells. J Antimicrob Chemother (1981) 2.29
Role of Pseudomonas aeruginosa PhoP-phoQ in resistance to antimicrobial cationic peptides and aminoglycosides. Microbiology (2000) 2.21
PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance. Mol Microbiol (1999) 2.19
Interaction of cationic antimicrobial peptides with model membranes. J Biol Chem (2001) 2.16
Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F. J Bacteriol (1986) 2.15
Antiendotoxin activity of cationic peptide antimicrobial agents. Infect Immun (1996) 2.13
Pseudomonas aeruginosa outer membrane: peptidoglycan-associated proteins. J Bacteriol (1981) 2.06
Role of porins in outer membrane permeability. J Bacteriol (1987) 2.06
The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin. Infect Immun (1995) 2.03
Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2000) 1.99
Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. J Bacteriol (1999) 1.96
Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression. J Immunol (2000) 1.93
Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol (2000) 1.93
Interaction of macrophage cationic proteins with the outer membrane of Pseudomonas aeruginosa. Infect Immun (1988) 1.92
Binding of polycationic antibiotics and polyamines to lipopolysaccharides of Pseudomonas aeruginosa. J Bacteriol (1985) 1.90
PhyloBLAST: facilitating phylogenetic analysis of BLAST results. Bioinformatics (2001) 1.89
Involvement of outer membrane of Pseudomonas cepacia in aminoglycoside and polymyxin resistance. Antimicrob Agents Chemother (1986) 1.87
Lipopolysaccharide-deficient, bacteriophage-resistant mutants of Escherichia coli K-12. J Bacteriol (1976) 1.86
Evidence for two distinct mechanisms of resistance to polymyxin B in Pseudomonas aeruginosa. Antimicrob Agents Chemother (1984) 1.81
Pseudomonas aeruginosa outer membrane protein F: structural role and relationship to the Escherichia coli OmpA protein. J Bacteriol (1989) 1.81
Salt-resistant alpha-helical cationic antimicrobial peptides. Antimicrob Agents Chemother (1999) 1.78
Monoclonal antibodies specific for Escherichia coli J5 lipopolysaccharide: cross-reaction with other gram-negative bacterial species. Infect Immun (1984) 1.77
Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids. Antimicrob Agents Chemother (1999) 1.76
In-vitro activity of newer quinolones against aerobic bacteria. J Antimicrob Chemother (1986) 1.71
The colicin I receptor of Escherichia coli K-12 has a role in enterochelin-mediated iron transport. FEBS Lett (1976) 1.68
Isolation of the outer membranes from Treponema pallidum and Treponema vincentii. J Bacteriol (1994) 1.67
Isolation of the outer membrane and characterization of the major outer membrane protein from Spirochaeta aurantia. J Bacteriol (1987) 1.67
Activity of ten antimicrobial agents against anaerobic bacteria. J Antimicrob Chemother (1978) 1.66
Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola. Infect Immun (1993) 1.66
Cellular events and intracellular survival of Campylobacter jejuni during infection of HEp-2 cells. Infect Immun (1989) 1.65
Quantitation and identification of antibodies to outer-membrane proteins of Pseudomonas aeruginosa in sera of patients with cystic fibrosis. J Infect Dis (1984) 1.62
Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus. Antimicrob Agents Chemother (1992) 1.62
Resistance occurring after fluoroquinolone therapy of experimental Pseudomonas aeruginosa peritonitis. Antimicrob Agents Chemother (1987) 1.62
In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii. Antimicrob Agents Chemother (1988) 1.61
Role of TNF and IL-1 in infections with Toxoplasma gondii. Immunology (1990) 1.61
Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity. J Biol Chem (1999) 1.61
Characterization of two surface-localized antigenic sites on porin protein F of Pseudomonas aeruginosa. Can J Microbiol (1985) 1.58
Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. Antimicrob Agents Chemother (2000) 1.58
Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles. Biochemistry (2000) 1.57
Alteration of susceptibility to EDTA, polymyxin B and gentamicin in Pseudomonas aeruginosa by divalent cation regulation of outer membrane protein H1. J Gen Microbiol (1983) 1.56
Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob Agents Chemother (2001) 1.56
A plasmid-mediated cephalosporinase from Achromobacter species. J Infect Dis (1982) 1.55
Contribution of beta-lactamase hydrolysis and outer membrane permeability to ceftriaxone resistance in Enterobacter cloacae. Antimicrob Agents Chemother (1987) 1.55
Isolation and characterization of a family of porin proteins from Helicobacter pylori. Infect Immun (1995) 1.52
Treatment of vascular graft infection by in situ replacement with a rifampin-bonded gelatin-sealed Dacron graft. J Vasc Surg (1994) 1.51
Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J Immunol (2000) 1.51
Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modification. Antimicrob Agents Chemother (1994) 1.51
Modulation of structure and antibacterial and hemolytic activity by ring size in cyclic gramicidin S analogs. J Biol Chem (1996) 1.50
Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides. Biochemistry (1999) 1.48
Mitogenic effects of purified outer membrane proteins from Pseudomonas aeruginosa. Infect Immun (1980) 1.48
Sequencing solution: use volunteer annotators organized via Internet. Nature (2000) 1.46
Demonstration and chemical modification of a specific phosphate binding site in the phosphate-starvation-inducible outer membrane porin protein P of Pseudomonas aeruginosa. Biochim Biophys Acta (1986) 1.42
Expression of host resistance to Salmonella typhi and Salmonella typhimurium: bacterial survival within macrophages of murine and human origin. Microb Pathog (1990) 1.42
Improved activity of a synthetic indolicidin analog. Antimicrob Agents Chemother (1997) 1.41
Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1). J Bacteriol (1995) 1.41
Role of Pseudomonas aeruginosa outer membrane protein OprH in polymyxin and gentamicin resistance: isolation of an OprH-deficient mutant by gene replacement techniques. Antimicrob Agents Chemother (1992) 1.41
Biological properties of structurally related alpha-helical cationic antimicrobial peptides. Infect Immun (1999) 1.40
The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa. Mol Microbiol (1994) 1.40
Outer membrane porin proteins F, P, and D1 of Pseudomonas aeruginosa and PhoE of Escherichia coli: chemical cross-linking to reveal native oligomers. J Bacteriol (1983) 1.40
Interaction of cationic peptides with lipoteichoic acid and gram-positive bacteria. Infect Immun (1999) 1.40
Outer-membrane protein PhoE from Escherichia coli forms anion-selective pores in lipid-bilayer membranes. Eur J Biochem (1984) 1.38
Effect of motility and chemotaxis on the invasion of Salmonella typhimurium into HeLa cells. Microb Pathog (1990) 1.38
Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens. Nat Biotechnol (2000) 1.37
A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1992) 1.37