PubRank

Alessandro Guidotti

Author PubWeight™ 64.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A 2005 3.12
2 Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A 2006 2.01
3 Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 2005 1.74
4 In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proc Natl Acad Sci U S A 2005 1.72
5 Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics 2007 1.70
6 Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) 2006 1.48
7 The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology 2012 1.40
8 A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci U S A 2003 1.38
9 Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophr Res 2007 1.34
10 The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacol Ther 2006 1.32
11 DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proc Natl Acad Sci U S A 2005 1.26
12 Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci U S A 2007 1.23
13 The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. Mol Pharmacol 2008 1.22
14 Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proc Natl Acad Sci U S A 2008 1.22
15 Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology 2012 1.21
16 Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics 2010 1.20
17 Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 2006 1.19
18 Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophr Res 2006 1.18
19 Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology 2011 1.17
20 SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol 2009 1.15
21 Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function. Neuropharmacology 2004 1.15
22 In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A 2003 1.14
23 In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. J Comp Neurol 2002 1.07
24 Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res 2008 1.03
25 The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr Opin Pharmacol 2002 1.02
26 Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev 2006 0.99
27 Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology 2011 0.99
28 Olfactory discrimination learning deficit in heterozygous reeler mice. Brain Res 2003 0.98
29 Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress 2005 0.98
30 Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proc Natl Acad Sci U S A 2010 0.97
31 Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol 2011 0.97
32 From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia. Epigenetics 2009 0.96
33 GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Rev Neurother 2009 0.96
34 Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci U S A 2004 0.95
35 Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proc Natl Acad Sci U S A 2005 0.95
36 Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention? Mol Interv 2003 0.95
37 GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Crit Rev Neurobiol 2003 0.94
38 Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. J Psychiatry Neurosci 2005 0.91
39 Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc Natl Acad Sci U S A 2006 0.91
40 Histone methylation at H3K9: evidence for a restrictive epigenome in schizophrenia. Schizophr Res 2013 0.88
41 Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. Toxicology 2008 0.88
42 Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem. Neuropharmacology 2008 0.87
43 DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol 2012 0.86
44 Advancing drug discovery for schizophrenia. Ann N Y Acad Sci 2011 0.86
45 Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology 2011 0.86
46 Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation. Epigenomics 2009 0.84
47 The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proc Natl Acad Sci U S A 2008 0.84
48 Brain neurosteroids in gender-related aggression induced by social isolation. Crit Rev Neurobiol 2004 0.83
49 Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Neuropharmacology 2004 0.83
50 Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology. Toxicol Sci 2010 0.80
51 L-methionine decreases dendritic spine density in mouse frontal cortex. Neuroreport 2010 0.80
52 Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives. Pharmacol Biochem Behav 2010 0.79
53 Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia? Schizophr Res 2005 0.79
54 Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage. Neuropharmacology 2011 0.78
55 5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. Psychopharmacology (Berl) 2014 0.78
56 Gene profiling of laser-microdissected brain regions and individual cells in drug abuse and schizophrenia research. Methods Mol Biol 2012 0.77
57 Varenicline treatment decreases DNMT1 mRNA expression in lymphocytes of schizophrenic patients who are cigarette smokers. Schizophr Res 2010 0.77
58 Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review. Curr Neuropharmacol 2016 0.76
59 [Stress and sleep/emotional disorder: possible involvement of neurosteroid allopregnanolone]. Nihon Yakurigaku Zasshi 2005 0.76
60 Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam. Neuropharmacology 2005 0.76
61 Preface. Fifty years of Neuropharmacology a tribute to Ermino Costa. Pharmacol Res 2011 0.75
62 The Fidia-Georgetown Institute for the Neurosciences (FGIN) 1985-1994. Pharmacol Res 2011 0.75