Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

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Published in Neuron on January 14, 2010

Authors

Venu M Nemani1, Wei Lu, Victoria Berge, Ken Nakamura, Bibiana Onoa, Michael K Lee, Farrukh A Chaudhry, Roger A Nicoll, Robert H Edwards

Author Affiliations

1: Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

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Dopamine neurons make glutamatergic synapses in vitro. J Neurosci (1998) 2.33

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