Published in Cell on November 04, 2005
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell (2011) 6.23
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron (2010) 4.76
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron (2011) 4.74
Genetic animal models of Parkinson's disease. Neuron (2010) 3.86
Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci (2006) 3.73
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron (2013) 2.94
Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest (2006) 2.86
The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci (2013) 2.78
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence. Proc Natl Acad Sci U S A (2009) 2.59
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc Natl Acad Sci U S A (2008) 2.00
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med (2008) 1.90
Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol Biol Cell (2010) 1.89
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nat Rev Genet (2009) 1.84
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc Natl Acad Sci U S A (2010) 1.83
Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem (2010) 1.82
A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci (2010) 1.80
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia. Acta Neuropathol (2010) 1.80
What causes cell death in Parkinson's disease? Ann Neurol (2008) 1.66
The function of α-synuclein. Neuron (2013) 1.63
α-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.62
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci (2011) 1.56
A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J (2014) 1.55
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. Am J Pathol (2007) 1.52
Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis. PLoS One (2011) 1.51
Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim Biophys Acta (2008) 1.51
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci (2010) 1.49
Animal models of Parkinson's disease progression. Acta Neuropathol (2008) 1.49
α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends Neurosci (2010) 1.49
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell (2008) 1.48
Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation (2006) 1.47
Cysteine string protein limits expression of the large conductance, calcium-activated K⁺ (BK) channel. PLoS One (2014) 1.46
Residual structure, backbone dynamics, and interactions within the synuclein family. J Mol Biol (2007) 1.43
α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol (2012) 1.42
Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiol Aging (2008) 1.41
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res (2008) 1.40
The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms. J Biol Chem (2010) 1.39
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. Brain (2010) 1.38
CSPα knockout causes neurodegeneration by impairing SNAP-25 function. EMBO J (2011) 1.37
Heat shock proteins: cellular and molecular mechanisms in the central nervous system. Prog Neurobiol (2010) 1.37
Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein. Hum Mol Genet (2009) 1.37
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest (2009) 1.35
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener (2012) 1.34
Integrating pathways of Parkinson's disease in a molecular interaction map. Mol Neurobiol (2013) 1.34
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. Elife (2013) 1.31
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism. J Neurochem (2008) 1.31
Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic (2008) 1.30
Identification of CSPα clients reveals a role in dynamin 1 regulation. Neuron (2012) 1.28
Monomeric synucleins generate membrane curvature. J Biol Chem (2012) 1.27
The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective. ASN Neuro (2010) 1.26
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc Natl Acad Sci U S A (2013) 1.26
Alpha-synuclein: from secretion to dysfunction and death. Cell Death Dis (2012) 1.25
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. Proc Natl Acad Sci U S A (2006) 1.23
VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the exocrine system. Mol Biol Cell (2007) 1.22
Autoantibodies to alpha-synuclein in inherited Parkinson's disease. J Neurochem (2007) 1.22
Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci (2012) 1.22
Genes associated with Parkinson syndrome. J Neurol (2008) 1.21
Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease. Biochemistry (2011) 1.20
Dual role of the cysteine-string domain in membrane binding and palmitoylation-dependent sorting of the molecular chaperone cysteine-string protein. Mol Biol Cell (2006) 1.20
MicroRNA-7a regulates pancreatic β cell function. J Clin Invest (2014) 1.18
Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep (2010) 1.17
Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiol (2006) 1.17
α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci (2011) 1.16
Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol (2011) 1.14
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol (2009) 1.14
A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One (2010) 1.13
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases. Pharmaceuticals (Basel) (2010) 1.13
Sumoylation inhibits alpha-synuclein aggregation and toxicity. J Cell Biol (2011) 1.13
{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. Mol Biol Cell (2009) 1.11
Immunological features of alpha-synuclein in Parkinson's disease. J Cell Mol Med (2008) 1.10
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. J Neurosci (2012) 1.10
Synucleins regulate the kinetics of synaptic vesicle endocytosis. J Neurosci (2014) 1.10
Snaring the function of alpha-synuclein. Cell (2005) 1.09
The Hsp90 chaperone complex regulates GDI-dependent Rab recycling. Mol Biol Cell (2006) 1.09
Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res (2009) 1.08
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells. Am J Pathol (2007) 1.08
Chaperoning the SNAREs: a role in preventing neurodegeneration? Nat Cell Biol (2011) 1.07
Evolution of the human-specific microRNA miR-941. Nat Commun (2012) 1.06
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts. Acta Neuropathol (2011) 1.06
Folding and misfolding of alpha-synuclein on membranes. Biochim Biophys Acta (2011) 1.06
Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease. Angew Chem Int Ed Engl (2010) 1.06
The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition. J Biol Chem (2010) 1.05
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener (2009) 1.05
Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. PLoS Genet (2012) 1.04
In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. PLoS One (2010) 1.02
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta (2008) 1.01
Synuclein modulation of monoamine transporters. FEBS Lett (2011) 1.01
Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Mol Med (2009) 1.00
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis (2011) 0.99
Alpha-synuclein function and dysfunction on cellular membranes. Exp Neurobiol (2014) 0.99
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron (2008) 2.15
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
In vivo cocaine experience generates silent synapses. Neuron (2009) 2.11
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
A neural circuit for memory specificity and generalization. Science (2013) 1.96
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron (2011) 1.89
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J (2002) 1.88
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. J Neurosci (2005) 1.87
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J (2005) 1.86
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis. J Neurosci (2006) 1.82
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem (2003) 1.82
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron (2007) 1.81
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release. Neuron (2013) 1.78
Induced neuronal cells: how to make and define a neuron. Cell Stem Cell (2011) 1.77
Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proc Natl Acad Sci U S A (2004) 1.76
Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell (2003) 1.75
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. J Neurosci (2009) 1.74
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron (2004) 1.74
Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A (2007) 1.74
Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron (2012) 1.74
Comprehensive qPCR profiling of gene expression in single neuronal cells. Nat Protoc (2011) 1.73
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell (2013) 1.70
A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci (2011) 1.68
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion. J Neurosci (2006) 1.68
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry (2006) 1.67
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A (2007) 1.67
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci (2013) 1.65
Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells. Proc Natl Acad Sci U S A (2008) 1.63
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A (2011) 1.63
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Proc Natl Acad Sci U S A (2002) 1.62
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci (2006) 1.61
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proc Natl Acad Sci U S A (2011) 1.60
A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci (2009) 1.59
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci (2006) 1.58