Published in Biochim Biophys Acta on February 12, 2010
Emerging role of ISG15 in antiviral immunity. Cell (2010) 2.19
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature (2014) 2.10
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science (2012) 2.06
Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med (2011) 1.42
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators. PLoS Pathog (2016) 1.39
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Viral hijacking of the host ubiquitin system to evade interferon responses. Curr Opin Microbiol (2010) 1.12
Hepatitis C virus reveals a novel early control in acute immune response. PLoS Pathog (2011) 1.10
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virol J (2011) 1.03
Antiviral Properties of ISG15. Viruses (2010) 1.02
ISG15: leading a double life as a secreted molecule. Exp Mol Med (2013) 1.01
Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia. PLoS One (2012) 1.00
Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma. Oncotarget (2014) 1.00
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest (2012) 0.96
Increased cerebral protein ISGylation after focal ischemia is neuroprotective. J Cereb Blood Flow Metab (2011) 0.95
Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Res (2014) 0.94
Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection. Cell Mol Immunol (2014) 0.94
It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet (2013) 0.90
Ubiquitin-like proteins and their roles in archaea. Trends Microbiol (2012) 0.89
1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice. J Virol (2013) 0.87
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway. J Virol (2015) 0.85
Crystal structure of human ISG15 protein in complex with influenza B virus NS1B. J Biol Chem (2011) 0.85
Cardiac function and disease: emerging role of small ubiquitin-related modifier. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
Ubiquitin-fold modifier 1 acts as a positive regulator of breast cancer. Front Endocrinol (Lausanne) (2015) 0.84
Rickettsia conorii infection stimulates the expression of ISG15 and ISG15 protease UBP43 in human microvascular endothelial cells. Biochem Biophys Res Commun (2011) 0.83
Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response. J Virol (2013) 0.82
Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways. Int J Mol Sci (2012) 0.82
Innate defects of the IL-12/IFN-γ axis in susceptibility to infections by mycobacteria and salmonella. J Interferon Cytokine Res (2013) 0.81
Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80
Budding of Enveloped Viruses: Interferon-Induced ISG15-Antivirus Mechanisms Targeting the Release Process. Adv Virol (2012) 0.79
The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells. Biochem Biophys Res Commun (2012) 0.79
Dugbe virus ovarian tumour domain interferes with ubiquitin/ISG15-regulated innate immune cell signalling. J Gen Virol (2012) 0.79
Prognostic value of ISG15 mRNA level in drinkers with esophageal squamous cell cancers. Int J Clin Exp Pathol (2015) 0.79
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun (2016) 0.79
ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system. Oncotarget (2016) 0.78
Comparative analysis of selected innate immune-related genes following infection of immortal DF-1 cells with highly pathogenic (H5N1) and low pathogenic (H9N2) avian influenza viruses. Virus Genes (2015) 0.77
OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. PLoS One (2012) 0.77
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis. Invest Ophthalmol Vis Sci (2017) 0.77
Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation. Translation (Austin) (2014) 0.76
Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase. J Gen Virol (2015) 0.76
Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle. J Vet Sci (2015) 0.76
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Sci Rep (2017) 0.75
Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress. Mol Cells (2017) 0.75
Interferon-stimulated gene 15 in hepatitis B-related liver diseases. Oncotarget (2016) 0.75
Backbone and Ile-δ1, Leu, Val methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein. Biomol NMR Assign (2011) 0.75
UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells. Oncotarget (2017) 0.75
HPV16 E6 and E7 Upregulate Interferon-Induced Antiviral Response Genes ISG15 and IFIT1 in Human Trophoblast Cells. Pathogens (2017) 0.75
Roles of miR-138 and ISG15 in oral squamous cell carcinoma. Exp Ther Med (2017) 0.75
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature (2005) 2.43
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J Biol Chem (2006) 2.03
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Deubiquitinating enzymes as cellular regulators. J Biochem (2003) 1.60
Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase. J Biol Chem (2005) 1.53
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol (2008) 1.52
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat Cell Biol (2006) 1.52
EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell (2012) 1.48
A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47
The C-terminal tails of HslU ATPase act as a molecular switch for activation of HslV peptidase. J Biol Chem (2002) 1.39
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. EMBO Rep (2009) 1.30
Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem (2006) 1.26
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat Commun (2011) 1.19
The active site of a lon protease from Methanococcus jannaschii distinctly differs from the canonical catalytic Dyad of Lon proteases. J Biol Chem (2004) 1.15
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. EMBO J (2012) 1.12
Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat Cell Biol (2009) 1.12
Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells. J Cell Physiol (2005) 1.09
Oligomeric structure of the ATP-dependent protease La (Lon) of Escherichia coli. Mol Cells (2006) 1.07
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Nat Cell Biol (2006) 1.06
Structural basis for Ufm1 processing by UfSP1. J Biol Chem (2008) 1.04
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A (2007) 1.03
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J Biol Chem (2006) 1.02
Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. Mol Biol Cell (2008) 0.98
Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69. Proc Natl Acad Sci U S A (2002) 0.97
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest (2012) 0.96
Control of adipogenesis by the SUMO-specific protease SENP2. Mol Cell Biol (2010) 0.93
Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem (2011) 0.88
Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome. Reprod Fertil Dev (2003) 0.88
Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent. J Biol Chem (2008) 0.87
Effect of a peroxisome proliferator-activated receptor gamma sumoylation mutant on neointimal formation after balloon injury in rats. Atherosclerosis (2009) 0.85
HslVU ATP-dependent protease utilizes maximally six among twelve threonine active sites during proteolysis. J Biol Chem (2009) 0.81
A Method for Assaying Deubiquitinating Enzymes. Biol Proced Online (1998) 0.81
Strategies for assaying deubiquitinating enzymes. Methods Enzymol (2005) 0.79
USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci (2013) 0.78
Molecular architecture of the ATP-dependent CodWX protease having an N-terminal serine active site. EMBO J (2003) 0.78
Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells. J Cell Sci (2002) 0.78
Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase. Mol Cells (2007) 0.76
Crystal structure of Bacillus subtilis CodW, a noncanonical HslV-like peptidase with an impaired catalytic apparatus. Proteins (2008) 0.75
Structural alteration in the pore motif of the bacterial 20S proteasome homolog HslV leads to uncontrolled protein degradation. J Mol Biol (2013) 0.75