Published in Clin Cancer Res on February 16, 2010
STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 1.62
The SLC39 family of zinc transporters. Mol Aspects Med (2013) 1.41
Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr (2011) 1.35
Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets. Cancer Invest (2012) 1.12
Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration. PLoS One (2010) 1.09
A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med (2013) 0.96
ZIP4 is a novel molecular marker for glioma. Neuro Oncol (2013) 0.95
A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). Biochem J (2013) 0.90
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature (2015) 0.86
Imaging-guided curative surgical resection of pancreatic cancer in a xenograft mouse model. Cancer Lett (2012) 0.86
URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription. Cell Death Dis (2014) 0.85
ZIP4, a novel determinant of tumor invasion in hepatocellular carcinoma, contributes to tumor recurrence after liver transplantation. Int J Biol Sci (2014) 0.81
Study human pancreatic cancer in mice: how close are they? Biochim Biophys Acta (2012) 0.80
Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun. Oncotarget (2015) 0.78
ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer. Cell Cycle (2014) 0.78
Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations. Sci Rep (2015) 0.77
ZIP4 silencing improves bone loss in pancreatic cancer. Oncotarget (2015) 0.77
The Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets. PLoS One (2015) 0.76
Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun (2017) 0.75
Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. PLoS One (2013) 0.75
Zinc transporters are differentially expressed in human non-small cell lung cancer. Oncotarget (2016) 0.75
Structural insights of ZIP4 extracellular domain critical for optimal zinc transport. Nat Commun (2016) 0.75
SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer. Sci Rep (2017) 0.75
Pancreatic cancer. Lancet (2004) 11.63
Pancreatic carcinoma. N Engl J Med (1992) 7.25
Cancer statistics, 1998. CA Cancer J Clin (1998) 6.26
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet (2002) 2.41
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A (2006) 2.35
Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology (2003) 2.16
Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer (2004) 2.02
Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther (2008) 1.90
The role of zinc in growth and cell proliferation. J Nutr (2000) 1.89
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer (2006) 1.59
A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity. J Biol Chem (2007) 1.58
Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. Int J Oncol (2002) 1.53
Copper and zinc levels in normal and malignant tissues. Cancer (1983) 1.48
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. Biochem J (2003) 1.47
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett (2003) 1.42
Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate (2004) 1.37
Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci (2007) 1.35
Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res (2009) 1.30
Zinc-altered immune function and cytokine production. J Nutr (2000) 1.22
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene (2004) 1.19
Role of mononuclear cells and inflammatory cytokines in pancreatic cancer-related cachexia. Clin Cancer Res (2005) 1.18
IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer Biol Ther (2007) 1.08
Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia. Am J Physiol Cell Physiol (2006) 1.08
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Mol Cancer Res (2007) 1.02
Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp Gerontol (2007) 1.02
Expression of carbonic anhydrase IX in human pancreatic cancer. Aliment Pharmacol Ther (2003) 1.01
Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein. Exp Biol Med (Maywood) (2003) 1.01
Growth factors and cytokines in pancreatic carcinogenesis. Ann N Y Acad Sci (1999) 0.96
Hypoxia and angiogenesis in pancreatic cancer. ANZ J Surg (2006) 0.95
That zincing feeling: the effects of EDTA on the behaviour of zinc-binding transcriptional regulators. Biochem J (2004) 0.93
Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3. Mol Cancer Res (2009) 0.92
Targeted drug delivery in pancreatic cancer. Biochim Biophys Acta (2009) 0.92
Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression. J Biol Chem (2007) 0.91
Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes. Lymphokine Cytokine Res (1994) 0.90
Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2. Oncogene (2003) 0.90
Expression of IL-6 receptor in pancreatic cancer: involvement in VEGF induction. Anticancer Res (2003) 0.90
A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution. Structure (2002) 0.89
Induction of interferon-gamma in human leukocyte cultures stimulated by Zn2+. Clin Immunol Immunopathol (1987) 0.88
Interleukin-1alpha, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer. Hepatobiliary Pancreat Dis Int (2005) 0.87
Differential effects of copper and zinc on human peripheral blood monocyte cytokine secretion. Cell Immunol (1990) 0.86
IL-6 protects enterocytes from hypoxia-induced apoptosis by induction of bcl-2 mRNA and reduction of fas mRNA. Biochem Biophys Res Commun (2006) 0.84
Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons. Nutr Neurosci (2008) 0.79
Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells. Exp Biol Med (Maywood) (2006) 0.79
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75
Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res (2008) 5.21
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res (2009) 4.19
A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res (2009) 3.87
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology (2010) 3.57
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell (2008) 3.44
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A (2012) 3.03
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation (2012) 2.54
Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol (2005) 2.51
Essential Staphylococcus aureus toxin export system. Nat Med (2013) 2.50
Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol (2009) 2.44
Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst (2008) 2.37
Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn (2009) 2.35
Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg (2009) 2.31
High accuracy information extraction of medication information from clinical notes: 2009 i2b2 medication extraction challenge. J Am Med Inform Assoc (2010) 2.29
Ras activity levels control the development of pancreatic diseases. Gastroenterology (2009) 2.17
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol (2013) 2.14
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest (2012) 2.13
Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel. J Gen Physiol (2010) 2.09
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 2.08
Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta (2009) 2.08
StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut (2011) 2.07
S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem (2003) 2.05
Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus. J Bacteriol (2004) 2.04
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell (2009) 2.04
Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood (2006) 1.98
Asymptomatic cerebral microbleeds in adult patients with moyamoya disease: a prospective cohort study with 2 years of follow-up. Cerebrovasc Dis (2013) 1.97
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem (2001) 1.97
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Defining cell-type specificity at the transcriptional level in human disease. Genome Res (2013) 1.96
S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res (2005) 1.95
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell (2010) 1.92
Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther (2008) 1.90
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell (2007) 1.89
NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology (2002) 1.84
Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chem Pharm Bull (Tokyo) (2008) 1.83
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol (2009) 1.81
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A (2007) 1.81
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A (2003) 1.81
p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol (2006) 1.81
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res (2004) 1.80
MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res (2013) 1.80
HIV protease inhibitor ritonavir induces cytotoxicity of human endothelial cells. Arterioscler Thromb Vasc Biol (2002) 1.78
Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier. J Am Soc Nephrol (2009) 1.77
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood (2013) 1.70
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet (2010) 1.69
Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology (2012) 1.68
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67
A permissive role of mushroom body α/β core neurons in long-term memory consolidation in Drosophila. Curr Biol (2012) 1.67
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A (2005) 1.65
G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects. J Gen Physiol (2007) 1.64
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood (2008) 1.63
A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci (2013) 1.63
ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts. Cancer Biol Ther (2010) 1.63
Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains. J Physiol (2002) 1.62
Roles for KRAS in pancreatic tumor development and progression. Gastroenterology (2013) 1.61
MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med (2011) 1.59
Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer (2006) 1.59
Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene. Am J Hum Genet (2005) 1.57
Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival. Cancer Res (2008) 1.57
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies. Blood (2013) 1.56
Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci (2008) 1.54
Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol (2012) 1.53
Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin Cancer Res (2008) 1.52
DNA microarray analysis of genome dynamics in Yersinia pestis: insights into bacterial genome microevolution and niche adaptation. J Bacteriol (2004) 1.52
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med (2009) 1.51
Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with Duke's stage. Cancer Biol Ther (2010) 1.50
Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res (2004) 1.47
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet (2011) 1.46
The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol (2006) 1.46
Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. Am J Pathol (2002) 1.46
A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res (2011) 1.45
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells. Mol Cancer Ther (2006) 1.45
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res (2006) 1.45
Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk. Cancer Cell (2011) 1.44
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis. Gene (2012) 1.44