|
1
|
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
|
Cell Metab
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2005
|
5.39
|
|
2
|
Common variants in WFS1 confer risk of type 2 diabetes.
|
Nat Genet
|
2007
|
3.58
|
|
3
|
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
|
J Clin Invest
|
2010
|
2.22
|
|
4
|
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
|
J Clin Invest
|
2004
|
2.09
|
|
5
|
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.
|
Hum Mol Genet
|
2008
|
1.98
|
|
6
|
A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.
|
Diabetes
|
2004
|
1.83
|
|
7
|
Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.
|
J Biol Chem
|
2003
|
1.77
|
|
8
|
LKB1 regulates pancreatic beta cell size, polarity, and function.
|
Cell Metab
|
2009
|
1.70
|
|
9
|
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
|
Proc Natl Acad Sci U S A
|
2006
|
1.63
|
|
10
|
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
|
Diabetes
|
2008
|
1.61
|
|
11
|
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
|
PLoS Biol
|
2008
|
1.40
|
|
12
|
Assessing allele frequencies of single nucleotide polymorphisms in DNA pools by pyrosequencing technology.
|
Biotechniques
|
2002
|
1.34
|
|
13
|
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
|
Diabetes
|
2008
|
1.33
|
|
14
|
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.
|
Diabetes
|
2005
|
1.32
|
|
15
|
Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.
|
Diabetes
|
2006
|
1.31
|
|
16
|
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
|
Diabetes
|
2004
|
1.25
|
|
17
|
Transcriptional program of the endocrine pancreas in mice and humans.
|
Diabetes
|
2003
|
1.23
|
|
18
|
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.
|
Diabetes
|
2002
|
1.23
|
|
19
|
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
|
J Biol Chem
|
2004
|
1.18
|
|
20
|
Early brain vulnerability in Wolfram syndrome.
|
PLoS One
|
2012
|
1.17
|
|
21
|
Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.
|
Diabetes
|
2005
|
1.13
|
|
22
|
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
|
Genes Dev
|
2009
|
1.08
|
|
23
|
Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.
|
Diabetes
|
2004
|
1.06
|
|
24
|
Phenotypic characteristics of early Wolfram syndrome.
|
Orphanet J Rare Dis
|
2013
|
0.99
|
|
25
|
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.
|
PLoS One
|
2011
|
0.93
|
|
26
|
A global approach to identify differentially expressed genes in cDNA (two-color) microarray experiments.
|
Bioinformatics
|
2007
|
0.92
|
|
27
|
HNF4A genetic variants: role in diabetes.
|
Curr Opin Clin Nutr Metab Care
|
2007
|
0.92
|
|
28
|
Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
|
PLoS One
|
2010
|
0.92
|
|
29
|
Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.
|
PLoS One
|
2010
|
0.89
|
|
30
|
Gene expression profiling in islet biology and diabetes research.
|
Diabetes Metab Res Rev
|
2003
|
0.85
|
|
31
|
Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells.
|
Diabetes
|
2002
|
0.84
|
|
32
|
Balance impairment in individuals with Wolfram syndrome.
|
Gait Posture
|
2012
|
0.81
|