Published in Cell Metab on October 01, 2009
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet (2013) 2.71
Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. Nat Neurosci (2014) 2.22
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LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Mol Metab (2015) 0.90
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells. J Biol Chem (2012) 0.89
Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction. Diabetes (2012) 0.89
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Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis. Stem Cells (2014) 0.85
LKB1 signaling in advancing cell differentiation. Fam Cancer (2011) 0.85
SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells. Mol Cell Biol (2013) 0.84
Impact of islet architecture on β-cell heterogeneity, plasticity and function. Nat Rev Endocrinol (2016) 0.84
Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature. Diabetologia (2014) 0.84
Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles. J Cell Physiol (2015) 0.82
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Dis Model Mech (2014) 0.81
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Deletion of Lkb1 in adult mice results in body weight reduction and lethality. Sci Rep (2016) 0.77
Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr (2013) 0.77
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nat Commun (2016) 0.77
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Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. PLoS One (2016) 0.75
Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts. Int J Biochem Cell Biol (2016) 0.75
Subcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells. Sci Rep (2014) 0.75
Cell polarity defines three distinct domains in pancreatic β-cells. J Cell Sci (2016) 0.75
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (2017) 0.75
Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis. Cell Death Dis (2017) 0.75
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 12.35
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
The primary cilium as the cell's antenna: signaling at a sensory organelle. Science (2006) 6.79
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res (2007) 5.45
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 5.00
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41
Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell (2004) 3.87
Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature (2007) 3.71
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature (2001) 3.65
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell (2007) 3.49
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest (2001) 3.29
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol (2000) 3.27
LKB1/STRAD promotes axon initiation during neuronal polarization. Cell (2007) 3.25
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Retracted LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol (2007) 2.40
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol (2004) 2.16
Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes (1988) 2.15
Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science (1989) 2.04
Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes. Am J Surg Pathol (2005) 2.04
Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science (2002) 2.03
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol (2008) 1.96
Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol Cell (1998) 1.91
Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes (2007) 1.78
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development (2004) 1.73
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem (2007) 1.62
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol (2006) 1.61
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A (2008) 1.56
Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci U S A (2006) 1.36
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2004) 1.23
Transcriptional program of the endocrine pancreas in mice and humans. Diabetes (2003) 1.23
Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes (2005) 1.16
Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab (2004) 1.13
Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol (2007) 1.08
Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol (2005) 1.08
EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes. Nucleic Acids Res (2006) 1.02
Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling. Mol Biol Cell (2007) 1.01
LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol (2008) 0.91
Pancreatic beta cells: responding to the matrix. Cell Metab (2006) 0.85
Novel genes identified by manual annotation and microarray expression analysis in the pancreas. Genomics (2006) 0.82
Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters. J Cell Biol (2008) 0.81
OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res (2003) 33.03
Design and implementation of microarray gene expression markup language (MAGE-ML). Genome Biol (2002) 16.75
Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol (2008) 12.96
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OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups. Nucleic Acids Res (2006) 11.43
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2006) 8.26
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
A simple spreadsheet-based, MIAME-supportive format for microarray data: MAGE-TAB. BMC Bioinformatics (2006) 7.53
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
The MGED Ontology: a resource for semantics-based description of microarray experiments. Bioinformatics (2006) 7.37
PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res (2008) 6.73
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell (2009) 6.23
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PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data. Nucleic Acids Res (2003) 6.19
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature (2008) 5.96
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab (2005) 5.39
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Promoter features related to tissue specificity as measured by Shannon entropy. Genome Biol (2005) 5.19
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci (2006) 5.11
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med (2002) 5.10
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 5.00
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev (2008) 4.83
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41
The Plasmodium genome database. Nature (2002) 4.36
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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
Predicting gene ontology functions from ProDom and CDD protein domains. Genome Res (2002) 4.06
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A (2002) 4.06
ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res (2007) 3.96
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science (2011) 3.77
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Development of FuGO: an ontology for functional genomics investigations. OMICS (2006) 3.59
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
The Functional Genomics Experiment model (FuGE): an extensible framework for standards in functional genomics. Nat Biotechnol (2007) 3.55
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology (2007) 3.41
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell (2010) 3.40
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature (2012) 3.40
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments. Genome Res (2006) 3.21
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog Biophys Mol Biol (2003) 3.09
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Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell (2005) 2.98
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Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
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Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
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Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology (2014) 2.40
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
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An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature (2012) 2.35
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res (2011) 2.35
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med (2013) 2.31
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PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab (2012) 2.24
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol (2003) 2.24
Propagation of adipogenic signals through an epigenomic transition state. Genes Dev (2010) 2.23
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
Somatic LKB1 mutations promote cervical cancer progression. PLoS One (2009) 2.21
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups. Curr Protoc Bioinformatics (2011) 2.15