Published in Cell Death Differ on January 01, 2010
While p73 is essential, p63 is completely dispensable for the development of the central nervous system. Cell Cycle (2011) 2.31
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development (2012) 1.97
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
MicroRNA-203 contributes to skin re-epithelialization. Cell Death Dis (2012) 1.05
Tissue-specific expression of p73 C-terminal isoforms in mice. Cell Cycle (2012) 0.84
Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63. J Skin Cancer (2013) 0.80
Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature. Oncotarget (2016) 0.77
TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: regulation by vitamin D3 Metabolites. PLoS One (2015) 0.75
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev (1999) 6.87
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins. Cell Death Differ (2009) 1.93
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
Structural evolution of C-terminal domains in the p53 family. EMBO J (2007) 1.32
A link between p73 transcriptional activity and p73 degradation. Oncogene (2004) 0.95
HPRT minigene generates chimeric transcripts as a by-product of gene targeting. Genesis (2007) 0.94
A new p63-deficient mouse model or a fresh look at an old one? Cell Death Differ (2009) 0.89
Treasure or artifact: a decade of p63 research speaks for itself. Cell Death Differ (2010) 0.86
p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell (2012) 4.11
p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res (2008) 3.58
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal (2005) 3.50
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
Transcription-independent pro-apoptotic functions of p53. Curr Opin Cell Biol (2005) 2.88
Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62
Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect Immun (2005) 2.60
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol (2004) 2.50
DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med (2002) 2.48
p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem (2003) 2.43
While p73 is essential, p63 is completely dispensable for the development of the central nervous system. Cell Cycle (2011) 2.31
p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res (2008) 2.27
Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway. Cancer Res (2006) 2.17
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol (2005) 2.13
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle (2009) 2.00
A polymorphic microsatellite that mediates induction of PIG3 by p53. Nat Genet (2002) 1.97
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J Biol Chem (2006) 1.94
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle (2009) 1.56
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma. Leuk Lymphoma (2006) 1.51
p63 antagonizes Wnt-induced transcription. Cell Cycle (2010) 1.47
p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell (2007) 1.41
Links between mutant p53 and genomic instability. J Cell Biochem (2012) 1.41
Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy. Cancer Res (2006) 1.39
Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Cancer Res (2004) 1.36
p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop. Oncogene (2002) 1.36
Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage. FASEB J (2002) 1.34
deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo. Mol Cell Biol (2003) 1.33
Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res (2005) 1.33
MicroRNA-449 in cell fate determination. Cell Cycle (2011) 1.31
Direct reprogramming by oncogenic Ras and Myc. Proc Natl Acad Sci U S A (2013) 1.26
The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle (2007) 1.25
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med (2012) 1.23
The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie (2005) 1.20
Classic and novel roles of p53: prospects for anticancer therapy. Trends Mol Med (2007) 1.19
Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Mol Cell (2005) 1.17
Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups. Acta Neuropathol (2015) 1.16
Stress-induced p53 runs a transcription-independent death program. Biochem Biophys Res Commun (2005) 1.13
BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. J Biol Chem (2009) 1.12
Detection of mitochondrial localization of p53. Methods Mol Biol (2003) 1.11
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia. Cell Cycle (2010) 1.07
NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue. PLoS One (2008) 1.05
Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo. Clin Cancer Res (2005) 1.05
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage. FASEB J (2003) 1.04
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A (2011) 1.03
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g. Radiother Oncol (2013) 1.01
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. J Biol Chem (2002) 1.01
Specific inhibition of Mdm2-mediated neddylation by Tip60. Cell Cycle (2007) 1.01
Stress-induced p53 runs a direct mitochondrial death program: its role in physiologic and pathophysiologic stress responses in vivo. Cell Cycle (2004) 1.01
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways. J Cell Biol (2008) 1.00
A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy. Cell Cycle (2012) 0.99
Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J (2007) 0.98
Differential regulation of p63 and p73 expression. Oncogene (2003) 0.97
A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle (2008) 0.97
Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle. Cell Cycle (2007) 0.96
Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. Cell Cycle (2008) 0.96
Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA. Nucleic Acids Res (2004) 0.94
Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer. Eur J Cancer (2007) 0.94
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc Natl Acad Sci U S A (2013) 0.94
Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis. FEBS Lett (2005) 0.93
p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy. Mutat Res (2009) 0.93
E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection. J Virol (2004) 0.91
Role of the p53 family in stabilizing the genome and preventing polyploidization. Adv Exp Med Biol (2010) 0.91
A promoter that acquired p53 responsiveness during primate evolution. Cancer Res (2003) 0.90
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest (2010) 0.90
Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase. Cell Cycle (2013) 0.89
Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One (2012) 0.88
DeltaNp73 can modulate the expression of various genes in a p53-independent fashion. Oncogene (2003) 0.87
Mutual interference of adenovirus infection and myc expression. J Virol (2003) 0.87
Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny. Cancer Res (2006) 0.86
p73 and p63: why do we still need them? Cell Cycle (2004) 0.86
TAp73 is essential for germ cell adhesion and maturation in testis. J Cell Biol (2014) 0.86
Identification of p53 in mitochondria. Methods Mol Biol (2013) 0.85
Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and -34 making the decision? Cell Cycle (2009) 0.85
Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer. Curr Opin Oncol (2014) 0.85
Role of p53 family members p73 and p63 in human hematological malignancies. Leuk Lymphoma (2012) 0.84
Genomic profiling reveals distinctive molecular relapse patterns in IDH1/2 wild-type glioblastoma. Genes Chromosomes Cancer (2014) 0.83
Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers. Int J Oncol (2006) 0.82
Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53. J Gen Virol (2002) 0.81
Analysis of nuclear and cytoplasmic degradation of p53 in cells after stress. Methods Mol Biol (2003) 0.81
Cortical hypoplasia and ventriculomegaly of p73-deficient mice: Developmental and adult analysis. J Comp Neurol (2014) 0.80
Interaction of p53 with the adenovirus E1B-55 kDa protein. Methods Mol Biol (2003) 0.80
Reactivation of mutant p53 by a one-hybrid adaptor protein. Cancer Res (2003) 0.80
E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression. Cell Cycle (2008) 0.80
Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP. Methods Mol Biol (2003) 0.80
Enhanced cytotoxicity without internuclear spread of adenovirus upon cell fusion by measles virus glycoproteins. J Virol (2005) 0.79
Mutational analysis of p53 in human tumors: immunocytochemistry. Methods Mol Biol (2003) 0.79
HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates. Oncoimmunology (2012) 0.78