Published in Methods Mol Biol on January 01, 2013
Mitochondrial BMI1 maintains bioenergetic homeostasis in cells. FASEB J (2016) 0.76
Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect. PLoS One (2014) 0.76
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Oncotarget (2016) 0.75
The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosis. J Neurosci Res (2015) 0.75
Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction. Cell Signal (2013) 0.75
Mitochondrial protein alterations in a familial peripheral neuropathy caused by the V144D amino acid mutation in the sphingolipid protein, SPTLC1. J Chem Biol (2014) 0.75
p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell (2012) 4.11
p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res (2008) 3.58
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol (2004) 2.50
DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med (2002) 2.48
p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res (2008) 2.27
Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway. Cancer Res (2006) 2.17
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle (2009) 2.00
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J Biol Chem (2006) 1.94
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77
p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell (2007) 1.41
Links between mutant p53 and genomic instability. J Cell Biochem (2012) 1.41
Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Cancer Res (2004) 1.36
Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage. FASEB J (2002) 1.34
deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo. Mol Cell Biol (2003) 1.33
Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res (2005) 1.33
Direct reprogramming by oncogenic Ras and Myc. Proc Natl Acad Sci U S A (2013) 1.26
The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle (2007) 1.25
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med (2012) 1.23
Classic and novel roles of p53: prospects for anticancer therapy. Trends Mol Med (2007) 1.19
Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Mol Cell (2005) 1.17
Stress-induced p53 runs a transcription-independent death program. Biochem Biophys Res Commun (2005) 1.13
BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. J Biol Chem (2009) 1.12
Detection of mitochondrial localization of p53. Methods Mol Biol (2003) 1.11
Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo. Clin Cancer Res (2005) 1.05
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage. FASEB J (2003) 1.04
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A (2011) 1.03
Stress-induced p53 runs a direct mitochondrial death program: its role in physiologic and pathophysiologic stress responses in vivo. Cell Cycle (2004) 1.01
Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J (2007) 0.98
A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle (2008) 0.97
Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle. Cell Cycle (2007) 0.96
Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. Cell Cycle (2008) 0.96
Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA. Nucleic Acids Res (2004) 0.94
Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer. Eur J Cancer (2007) 0.94
p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy. Mutat Res (2009) 0.93
Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis. FEBS Lett (2005) 0.93
Role of the p53 family in stabilizing the genome and preventing polyploidization. Adv Exp Med Biol (2010) 0.91
Brdm2 - an aberrant hypomorphic p63 allele. Cell Death Differ (2010) 0.90
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest (2010) 0.90
Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase. Cell Cycle (2013) 0.89
TAp73 is essential for germ cell adhesion and maturation in testis. J Cell Biol (2014) 0.86
Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer. Curr Opin Oncol (2014) 0.85
Role of p53 family members p73 and p63 in human hematological malignancies. Leuk Lymphoma (2012) 0.84
Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers. Int J Oncol (2006) 0.82
Analysis of nuclear and cytoplasmic degradation of p53 in cells after stress. Methods Mol Biol (2003) 0.81
Cortical hypoplasia and ventriculomegaly of p73-deficient mice: Developmental and adult analysis. J Comp Neurol (2014) 0.80
E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression. Cell Cycle (2008) 0.80
Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP. Methods Mol Biol (2003) 0.80
Mutational analysis of p53 in human tumors: immunocytochemistry. Methods Mol Biol (2003) 0.79
HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates. Oncoimmunology (2012) 0.78
Generation of p53-deficient induced pluripotent stem cells from mouse embryo fibroblasts. Methods Mol Biol (2013) 0.77
p63 and canonical Wnt signaling. Cell Cycle (2010) 0.77
Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs. Nucleic Acids Res (2004) 0.76
p63 regulation by microRNAs. Cell Cycle (2009) 0.76
p53 further extends its reach. Oncoimmunology (2013) 0.75