G protein coupled receptors in embryonic stem cells: a role for Gs-alpha signaling.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 2816999)

Published in PLoS One on February 08, 2010

Authors

Brian T Layden1, Marsha Newman, Fei Chen, Amanda Fisher, William L Lowe

Author Affiliations

1: Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

Articles citing this

It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. Neurochem Res (2012) 0.94

Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. Stem Cell Res Ther (2013) 0.87

Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation. PLoS Biol (2012) 0.81

GPCRs in stem cell function. Prog Mol Biol Transl Sci (2013) 0.80

Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history. J Bone Miner Res (2014) 0.79

Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice. Stem Cell Res Ther (2011) 0.79

Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR. BMC Genomics (2011) 0.79

G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol (2015) 0.78

Somatostatin receptor type 2 contributes to the self-renewal of murine embryonic stem cells. Acta Pharmacol Sin (2014) 0.76

G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling. Front Cell Dev Biol (2015) 0.75

G protein-coupled receptors in stem cell maintenance and somatic reprogramming to pluripotent or cancer stem cells. BMB Rep (2015) 0.75

G Protein-Coupled Receptor Signaling in Stem Cells and Cancer. Int J Mol Sci (2016) 0.75

Articles cited by this

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell (2008) 10.34

Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol (2005) 9.58

Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov (2008) 6.18

The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol (2005) 4.07

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol (2002) 3.89

G proteins. Trends Biochem Sci (1992) 3.79

Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol Lett (2006) 3.53

Insights into G protein structure, function, and regulation. Endocr Rev (2003) 3.33

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature (2007) 3.01

Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther (2006) 2.71

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol (2004) 2.60

A role for thrombin receptor signaling in endothelial cells during embryonic development. Science (2001) 2.55

Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20

Inherited diseases involving g proteins and g protein-coupled receptors. Annu Rev Med (2004) 1.88

Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr Rev (2001) 1.85

The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell (2007) 1.68

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol (2004) 1.66

WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets (2008) 1.58

Heterotrimeric G proteins. Curr Opin Cell Biol (1996) 1.55

Apelin and its receptor control heart field formation during zebrafish gastrulation. Dev Cell (2007) 1.49

Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells. Stem Cells (2005) 1.44

Mouse embryo fibroblast (MEF) feeder cell preparation. Curr Protoc Mol Biol (2001) 1.35

Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther (2006) 1.33

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature (2009) 1.27

In vitro differentiation of mouse embryonic stem (mES) cells using the hanging drop method. J Vis Exp (2008) 1.20

Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology. Pharmacol Ther (2007) 1.15

SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells. Genomics (2002) 1.08

Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res (2007) 1.06

Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One (2007) 0.99

The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc Natl Acad Sci U S A (2008) 0.98

Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct4 expression: the role of the cAMP/PKA pathway. In Vitro Cell Dev Biol Anim (2007) 0.88

Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells. J Mol Signal (2008) 0.84

Mouse embryonic stem (ES) cell culture. Curr Protoc Mol Biol (2001) 0.80

Stem cells in biology, tissue engineering and medicine: the leading edge keeps moving. Curr Opin Biotechnol (2007) 0.77

Articles by these authors

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res (2005) 6.93

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20

Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Sci Transl Med (2011) 3.46

Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat Cell Biol (2007) 2.55

TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol (2005) 2.29

Interface-induced superconductivity and strain-dependent spin density waves in FeSe/SrTiO3 thin films. Nat Mater (2013) 2.15

Structural insights into the YAP and TEAD complex. Genes Dev (2010) 2.00

Optimizing low loss negative index metamaterial for visible spectrum using differential evolution. Opt Express (2011) 1.96

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood (2009) 1.94

Secondary Use of EHR: Data Quality Issues and Informatics Opportunities. AMIA Jt Summits Transl Sci Proc (2010) 1.81

Amplification, mutation, and sequencing of a six-letter synthetic genetic system. J Am Chem Soc (2011) 1.78

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol (2007) 1.77

Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage. Crit Care Med (2009) 1.51

Recurrent isolation of hydrogen peroxide-resistant spores of Bacillus pumilus from a spacecraft assembly facility. Astrobiology (2005) 1.46

Expanded genetic alphabets in the polymerase chain reaction. Angew Chem Int Ed Engl (2010) 1.38

Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care (2013) 1.35

Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop. Genet Epidemiol (2011) 1.33

Short chain fatty acids and their receptors: new metabolic targets. Transl Res (2012) 1.31

Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res (2004) 1.30

Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies. Genome Biol (2010) 1.29

Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell (2013) 1.28

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation (2008) 1.27

The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc (2011) 1.26

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol (2008) 1.25

Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res (2006) 1.23

Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2008) 1.23

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation (2006) 1.23

A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem (2003) 1.23

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener (2011) 1.23

Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. J Cell Mol Med (2008) 1.22

Inflammatory mediators and glucose in pregnancy: results from a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. J Clin Endocrinol Metab (2010) 1.21

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation. Biomaterials (2009) 1.21

Diseases caused by silica: mechanisms of injury and disease development. Int Immunopharmacol (2002) 1.20

Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials (2012) 1.20

Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol (2010) 1.19

Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin. Oncotarget (2013) 1.16

miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. Toxicol Sci (2011) 1.16

Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. Cell Cycle (2009) 1.16

The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene (2005) 1.16

Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction. J Biol Chem (2008) 1.16

Analysis of transcriptome differences between resistant and susceptible strains of the citrus red mite Panonychus citri (Acari: Tetranychidae). PLoS One (2011) 1.15

Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J Immunol (2006) 1.15

A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism. Anal Biochem (2002) 1.14

Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res (2010) 1.14

New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med (2015) 1.12

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. Diabetes (2010) 1.12

Microprocessor of microRNAs: regulation and potential for therapeutic intervention. Mol Cancer (2010) 1.11

Nuclear localization signal of ING4 plays a key role in its binding to p53. Biochem Biophys Res Commun (2005) 1.11

Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. Diagn Pathol (2013) 1.11

Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion. J Cell Mol Med (2008) 1.09

The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. J Immunol (2008) 1.08

Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J Gastroenterol (2004) 1.08

MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med (2013) 1.08

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. Mol Cancer (2009) 1.07

Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost (2012) 1.06

JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic. Cell Cycle (2012) 1.06

Bacillus nealsonii sp. nov., isolated from a spacecraft-assembly facility, whose spores are gamma-radiation resistant. Int J Syst Evol Microbiol (2003) 1.06

NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium. Toxicol Sci (2011) 1.05

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury. J Neuroinflammation (2014) 1.04

Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein. J Biol Chem (2012) 1.04

Layered PLG scaffolds for in vivo plasmid delivery. Biomaterials (2008) 1.04

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes (2013) 1.03

Genome-wide analysis and expression profile of the bZIP transcription factor gene family in grapevine (Vitis vinifera). BMC Genomics (2014) 1.03

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function. Aging Cell (2010) 1.02

Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo. Life Sci (2007) 1.02

Second-generation genetic linkage map of catfish and its integration with the BAC-based physical map. G3 (Bethesda) (2012) 1.01

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia. Tissue Eng Part A (2013) 1.01

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet (2012) 1.01

LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell (2012) 1.00

Hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulates liver cancer progression. Hepatology (2014) 0.99

Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. PLoS One (2009) 0.99

Role of waist measures in characterizing the lipid and blood pressure assessment of adolescents classified by body mass index. Arch Pediatr Adolesc Med (2012) 0.99

Knowledge levels and training needs of disaster medicine among health professionals, medical students, and local residents in Shanghai, China. PLoS One (2013) 0.98

JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure. Toxicol Sci (2012) 0.98

Effect of manufacturing defects on optical performance of discontinuous freeform lenses. Opt Express (2009) 0.97

(22E,24R)-3α,5-Cyclo-5α-ergosta-22-en-6-one. Acta Crystallogr Sect E Struct Rep Online (2011) 0.97

Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase. Eur J Cardiothorac Surg (2004) 0.97

The temporal lagged association between meteorological factors and malaria in 30 counties in south-west China: a multilevel distributed lag non-linear analysis. Malar J (2014) 0.96

DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma. Mol Cancer Ther (2012) 0.96

New reversing design method for LED uniform illumination. Opt Express (2011) 0.96

Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. J Investig Med (2006) 0.95

Sleep disturbance and cardiovascular risk in adolescents. CMAJ (2012) 0.95

Combined activin A/LiCl/Noggin treatment improves production of mouse embryonic stem cell-derived definitive endoderm cells. J Cell Biochem (2011) 0.95

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat. J Androl (2011) 0.95

Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma. Mol Med Rep (2011) 0.95

Comparative proteomic analysis of Typha angustifolia leaf under chromium, cadmium and lead stress. J Hazard Mater (2010) 0.94

Src-stimulated IRTKS phosphorylation enhances cell migration. FEBS Lett (2011) 0.94

Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection. Clin Exp Pharmacol Physiol (2012) 0.94

Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. Eur J Cancer Prev (2010) 0.94

Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression. Cancer Res (2007) 0.94

A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations. Genes Chromosomes Cancer (2005) 0.93

Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages. PLoS Pathog (2013) 0.93

Peptide-mediated inhibition of mitogen-activated protein kinase-activated protein kinase-2 ameliorates bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2013) 0.92

Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages. Am J Physiol Cell Physiol (2002) 0.92

The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet (2013) 0.92

Functionalisation of PLLA nanofiber scaffolds using a possible cooperative effect between collagen type I and BMP-2: impact on growth and osteogenic differentiation of human mesenchymal stem cells. J Mater Sci Mater Med (2011) 0.92

MLPA-based genotype-phenotype analysis in 1053 Chinese patients with DMD/BMD. BMC Med Genet (2013) 0.92

CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. Int J Oncol (2006) 0.92