New horizons in tumor microenvironment biology: challenges and opportunities.

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Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes. Oncotarget (2016) 0.87

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment. Oncogene (2016) 0.83

Royal Society Scientific Meeting: Extracellular vesicles in the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci (2018) 0.79

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Description of the immune microenvironment of chondrosarcoma and contribution to progression. Oncoimmunology (2016) 0.75

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases. Oncotarget (2016) 0.75

Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy. Int J Mol Sci (2017) 0.75

Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness. World J Hepatol (2017) 0.75

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Extracting tumor tissue immune status from expression profiles: correlating renal cancer prognosis with tumor-associated immunome. Oncotarget (2015) 0.75

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Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep (2016) 0.75

Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway. PPAR Res (2017) 0.75

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Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. Int J Mol Sci (2017) 0.75

Precision targeted therapy of ovarian cancer. J Control Release (2016) 0.75

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Molecular Pathways: Maintaining MAPK Inhibitor Sensitivity by Targeting Nonmutational Tolerance. Clin Cancer Res (2016) 0.75

p38 MAPK Inhibits Nonsense-mediated RNA Decay in Response to Persistent DNA Damage in Non-cycling Cells. J Biol Chem (2017) 0.75

Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov (2017) 0.75

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes. Stem Cells Int (2017) 0.75

Fusion with human lung cancer cells elongates the life span of human umbilical endothelial cells and enhances the anti-tumor immunity. J Cancer Res Clin Oncol (2015) 0.75

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The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer (2012) 10.90

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Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37

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Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell (2008) 7.47

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Cancer drug resistance: an evolving paradigm. Nat Rev Cancer (2013) 6.77

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell (2014) 5.87

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Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell (2012) 5.77

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell (2014) 5.38

The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28

A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89

Influence of tumour micro-environment heterogeneity on therapeutic response. Nature (2013) 4.78

Tumor-associated macrophages: from mechanisms to therapy. Immunity (2014) 4.69

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell (2011) 3.83

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Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. Genes Dev (2007) 3.31

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21

The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med (2013) 3.20

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04

Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell (2011) 2.96

DNA damage-mediated induction of a chemoresistant niche. Cell (2010) 2.94

Tumor clone dynamics in lethal prostate cancer. Sci Transl Med (2014) 2.93

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature (2014) 2.91

Therapeutic targeting of the tumor microenvironment. Cancer Cell (2005) 2.86

Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71

Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells (2009) 2.71

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer Cell (2014) 2.66

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer (2011) 2.56

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell (2011) 2.45

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A (2013) 2.41

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest (2013) 2.34

Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell (2007) 2.14

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell (2014) 2.06

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol (2014) 2.00

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res (2007) 1.97

CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell (2012) 1.97

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov (2013) 1.93

The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat Rev Immunol (2011) 1.82

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res (2009) 1.75

Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol (2008) 1.72

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem (2013) 1.62

Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell (2011) 1.62

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biol (2008) 1.62

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun (2013) 1.61

Overcoming implementation challenges of personalized cancer therapy. Nat Rev Clin Oncol (2012) 1.56

Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res (2012) 1.48

Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ (2012) 1.41

The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα. Cancer Discov (2014) 1.38

p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov (2014) 1.27

Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res (2013) 1.26

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol (2012) 1.20

Microenvironmental regulation of cancer metastasis by miRNAs. Trends Cell Biol (2013) 1.20

Challenges facing JAK inhibitor therapy for myeloproliferative neoplasms. N Engl J Med (2012) 1.19

A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clin Cancer Res (2012) 1.17

Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res (2013) 1.17

Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res (2014) 1.10

Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell (2012) 1.10

Cell-autonomous and non-cell-autonomous mechanisms of HGF/MET-driven resistance to targeted therapies: from basic research to a clinical perspective. Cancer Discov (2013) 1.09

NF-κB-induced KIAA1199 promotes survival through EGFR signalling. Nat Commun (2014) 1.09

Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell (2014) 1.07

A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer. Clin Cancer Res (2012) 1.07

The impact of tumor stroma on drug response in breast cancer. Semin Cancer Biol (2014) 1.06

Endothelin A receptor/β-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy. Cancer Res (2014) 1.02

Three-dimensional cultures of mouse mammary epithelial cells. Methods Mol Biol (2013) 1.01

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor. Oncotarget (2014) 1.00

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate. Proc Natl Acad Sci U S A (2014) 0.99

Deterministic and stochastic approaches in the clinical application of mesenchymal stromal cells (MSCs). Front Cell Dev Biol (2014) 0.98

Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy. Biomaterials (2014) 0.96

Targeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signaling. Onco Targets Ther (2014) 0.96

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation. PLoS One (2011) 0.95

Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation. Cell Death Dis (2013) 0.95

IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor-stroma interaction. Oncogene (2014) 0.95

p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene (2013) 0.95

Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer Discov (2013) 0.94

Stromal EGF and igf-I together modulate plasticity of disseminated triple-negative breast tumors. Cancer Discov (2013) 0.91

Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties. Cancer Res (2014) 0.91

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miR-629 Targets TRIM33 to Promote TGFβ/Smad Signaling and Metastatic Phenotypes in ccRCC. Mol Cancer Res (2014) 0.85

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