Published in Neuro Oncol on December 21, 2009
The response and survival of children with recurrent diffuse intrinsic pontine glioma based on phase II study of antineoplastons A10 and AS2-1 in patients with brainstem glioma. Childs Nerv Syst (2014) 2.66
Akt inhibitors in clinical development for the treatment of cancer. Expert Opin Investig Drugs (2010) 2.01
Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na. Leuk Res (2011) 1.20
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res (2011) 1.17
High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression. Neuro Oncol (2011) 1.06
Astrocyte elevated gene-1 interacts with Akt isoform 2 to control glioma growth, survival, and pathogenesis. Cancer Res (2014) 0.97
Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression. Proc Natl Acad Sci U S A (2015) 0.96
Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival. Mol Cancer (2012) 0.88
Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS One (2014) 0.85
Inhibition of heat-induced apoptosis in rat small intestine and IEC-6 cells through the AKT signaling pathway. BMC Vet Res (2013) 0.82
Knockdown of AKT3 (PKBγ) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells. Biomed Res Int (2014) 0.82
Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration. J Neurosurg (2016) 0.81
Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids. Cancer Cell Int (2012) 0.81
Identification of diagnostic markers in colorectal cancer via integrative epigenomics and genomics data. Oncol Rep (2015) 0.81
Growth inhibition of malignant glioblastoma by DING protein. J Neurooncol (2011) 0.81
MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA. Am J Cancer Res (2016) 0.78
Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis. Oncotarget (2016) 0.77
The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. J Neurooncol (2016) 0.77
AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma. Mol Cell Oncol (2015) 0.77
In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog. Invest New Drugs (2014) 0.77
OverAKT3: tumor progression and chemoresistance. Cell Cycle (2015) 0.76
Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation. Sci Rep (2015) 0.76
The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures. BMC Cancer (2017) 0.75
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun (2017) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Malignant glioma: genetics and biology of a grave matter. Genes Dev (2001) 6.78
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A (2005) 6.62
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet (2000) 5.28
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer (1995) 5.24
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol (2005) 5.00
AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A (2001) 4.88
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A (1996) 4.39
Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res (2004) 3.80
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell (2005) 3.78
Glioblastoma multiforme: the terminator. Proc Natl Acad Sci U S A (2000) 3.69
Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell (2003) 3.68
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol (1998) 3.51
The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene (2005) 3.42
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res (2003) 3.36
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res (2003) 3.30
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem (1999) 2.89
The developmental biology of brain tumors. Annu Rev Neurosci (2001) 2.82
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol (2001) 2.81
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. Cancer Res (2001) 2.16
Akt signaling and cancer: surviving but not moving on. Cancer Res (2006) 2.10
In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res (2000) 2.08
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog (1998) 2.06
Lessons learned in the development of targeted therapy for malignant gliomas. Mol Cancer Ther (2007) 1.74
Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res (1997) 1.62
Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res (2001) 1.47
Current epidemiological trends and surveillance issues in brain tumors. Expert Rev Anticancer Ther (2001) 1.46
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci U S A (2004) 1.43
Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. J Mol Cell Cardiol (2005) 1.38
Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. Biochem Biophys Res Commun (1996) 1.28
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. Cancer Res (2006) 1.26
Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis. Expert Rev Anticancer Ther (2004) 1.11
EGFR gene amplification--rearrangement in human glioblastomas. Int J Cancer (1995) 1.05
A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function. Curr Biol (1997) 1.02
REIC/Dkk-3 induces cell death in human malignant glioma. Neuro Oncol (2008) 1.00
Isoform-specific functions of Akt in cell motility. Cell Mol Life Sci (2007) 0.91
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma. Neuro Oncol (2008) 0.83
Oxidized LDL in carotid plaques and plasma associates with plaque instability. Arterioscler Thromb Vasc Biol (2002) 1.64
Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. J Biol Chem (2001) 1.62
Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism. Brain (2013) 1.53
Bilateral pallidal deep brain stimulation in primary Meige syndrome. Parkinsonism Relat Disord (2010) 1.51
Endothelial injury and inflammatory response induced by hemodynamic changes preceding intracranial aneurysm formation: experimental study in rats. J Neurosurg (2007) 1.17
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Stroke (2008) 1.17
Roles of hypertension in the rupture of intracranial aneurysms. Stroke (2013) 1.13
Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia. Proc Natl Acad Sci U S A (2008) 1.09
Evaluation of aneurysm stability after endovascular embolization with Guglielmi detachable coils: correlation between long-term stability and volume embolization ratio. Neurol Med Chir (Tokyo) (2005) 1.04
Angiographic changes in venous drainage of cavernous sinus dural arteriovenous fistulae after palliative transarterial embolization or observational management: a proposed stage classification. Neurosurgery (2005) 1.04
Serum response factor is modulated by the SUMO-1 conjugation system. Biochem Biophys Res Commun (2003) 1.03
Ischemic findings of T2*-weighted 3-tesla MRI in acute stroke patients. Cerebrovasc Dis (2008) 1.03
Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report. J Neurooncol (2007) 1.03
REIC/Dkk-3 induces cell death in human malignant glioma. Neuro Oncol (2008) 1.00
Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats. J Hypertens (2010) 1.00
Multidisciplinary consensus on assessment of unruptured intracranial aneurysms: proposal of an international research group. Stroke (2014) 0.99
The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. J Biol Chem (2002) 0.95
Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II: experimental study of the effects of hormone replacement therapy in rats. J Neurosurg (2005) 0.94
Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats. J Hypertens (2009) 0.94
Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia. Mov Disord (2008) 0.94
[Severe head injuries during Judo practice]. No Shinkei Geka (2011) 0.93
Brush sign on 3-T T2*-weighted MRI as a potential predictor of hemorrhagic transformation after tissue plasminogen activator therapy. Stroke (2013) 0.92
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. Hypertension (2009) 0.92
Characteristics, diagnosis and treatment of hypoglossal canal dural arteriovenous fistula: report of nine cases. Neuroradiology (2008) 0.92
Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients. J Anesth (2008) 0.92
Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson's disease. Mov Disord (2009) 0.91
Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies. J Hypertens (2008) 0.91
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. J Neurooncol (2009) 0.91
Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part I: experimental study of the effect of oophorectomy in rats. J Neurosurg (2005) 0.90
Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm: an experimental study in rats. J Neurosurg (2005) 0.90
Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: the Japan post-Marketing Alteplase Registration Study (J-MARS). Stroke (2010) 0.89
Ruptured aneurysm arising from a basilar artery fenestration and associated with a persistent primitive hypoglossal artery. Case report and review of the literature. J Neurosurg (2004) 0.89
Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. Hypertension (2014) 0.89
Neurocutaneous melanosis associated with malignant leptomeningeal melanoma in an adult: clinical significance of 5-S-cysteinyldopa in the cerebrospinal fluid---case report. Neurol Med Chir (Tokyo) (2003) 0.88
GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24. Clin Endocrinol (Oxf) (2003) 0.88
Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats. Neurosurgery (2010) 0.88
Activation of estrogen receptor-α and of angiotensin-converting enzyme 2 suppresses ischemic brain damage in oophorectomized rats. Hypertension (2011) 0.88
Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats. Stroke (2011) 0.88
Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas. Endocr Pathol (2009) 0.86
Anti-alpha-fodrin autoantibodies in Moyamoya disease. Stroke (2003) 0.86
Choreoathetosis due to rupture of a distal accessory anterior cerebral artery aneurysm. Cerebrovasc Dis (2008) 0.86
Elevation of plasma oxidized LDL in acute stroke patients is associated with ischemic lesions depicted by DWI and predictive of infarct enlargement. Neurol Res (2005) 0.86
Microcatheter pull-up technique in the transvenous embolization of an isolated sinus dural arteriovenous fistula. Technical note. J Neurosurg (2006) 0.86
Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction. Free Radic Biol Med (2005) 0.85
Reversibility of ischemic findings on 3-T T2*-weighted imaging after emergency superficial temporal artery-middle cerebral artery anastomosis in patients with progressive ischemic stroke. Neurol Med Chir (Tokyo) (2010) 0.85
Catastrophic head and neck injuries in judo players in Japan from 2003 to 2010. Am J Sports Med (2013) 0.85
Incidence and predictors of ischemic stroke events during hospitalization in patients with transient ischemic attack. Cerebrovasc Dis (2014) 0.85
Alleviation of camptocormia by bilateral subthalamic nucleus stimulation in a patient with Parkinson's disease. Parkinsonism Relat Disord (2006) 0.84
Clinical results of BNCT for malignant brain tumors in children. Appl Radiat Isot (2009) 0.84
Long-term outcome of severe stroke patients: is the ADL status at discharge from a stroke center indicative of the long-term outcome? J Med Invest (2011) 0.84
Boron neutron capture therapy for newly diagnosed glioblastoma. Radiother Oncol (2009) 0.84
Intraoperative Arachnoid Plasty Has Possibility to Prevent Chronic Subdural Hematoma after Surgery for Unruptured Cerebral Aneurysms. Neurol Med Chir (Tokyo) (2015) 0.84
A proposal for standardized analysis of the results of microvascular decompression for trigeminal neuralgia and hemifacial spasm. Acta Neurochir (Wien) (2012) 0.83
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma. Neuro Oncol (2008) 0.83
Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma. Cancer Lett (2012) 0.83
Ruptured de novo thrombotic giant aneurysm induced by ethyl 2-cyanoacrylate: case report. Surg Neurol (2004) 0.83
Dural arteriovenous fistulae after cerebral infarction: report of two cases. Neurosurgery (2011) 0.83