Published in Clin Cancer Res on March 01, 2000
Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res (2007) 2.50
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. BMC Cancer (2008) 2.47
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 1.82
Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. Gut (2003) 1.62
A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature (2015) 1.56
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. Br J Cancer (2010) 1.52
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest (2001) 1.51
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro Oncol (2011) 1.42
Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer (2006) 1.41
PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle (2009) 1.38
Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours. Br J Cancer (2009) 1.37
Akt2 and Akt3 play a pivotal role in malignant gliomas. Neuro Oncol (2009) 1.37
Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. Clin Cancer Res (2011) 1.35
Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol (2010) 1.27
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate. Br J Cancer (2010) 1.12
Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies. Eur J Cancer (2012) 1.11
AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma. World J Gastroenterol (2007) 1.10
Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells. Br J Cancer (2004) 1.09
Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis (2012) 1.08
Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer (2005) 1.07
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells. J Mol Cell Biol (2012) 1.07
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral Oncol (2006) 1.06
Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer. Cancer Discov (2012) 1.06
The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer (2005) 1.05
Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. J Control Release (2012) 0.99
Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo. J Exp Clin Cancer Res (2010) 0.98
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol (2012) 0.95
Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice. PLoS One (2007) 0.94
Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells. J Exp Clin Cancer Res (2008) 0.91
Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases. BMC Cancer (2014) 0.89
Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo. Int J Oncol (2012) 0.87
The PIK3CA gene as a mutated target for cancer therapy. Curr Cancer Drug Targets (2008) 0.86
hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer. Sci Rep (2013) 0.86
Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice. World J Gastroenterol (2009) 0.86
Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice. Arthritis Res Ther (2010) 0.85
Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells. Br J Cancer (2008) 0.84
Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells. Gynecol Oncol (2009) 0.84
The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy. Ann Surg (2006) 0.84
Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res (2012) 0.83
Proteomic analysis of temporally stimulated ovarian cancer cells for biomarker discovery. Mol Cell Proteomics (2012) 0.81
Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells. J Cardiovasc Pharmacol (2013) 0.81
Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells. Cancer Growth Metastasis (2012) 0.79
Research on drug resistance mechanism of trastuzumab caused by activation of the PI3K/Akt signaling pathway. Contemp Oncol (Pozn) (2013) 0.79
Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line. Proteome Sci (2013) 0.78
Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway. Int J Nanomedicine (2013) 0.78
Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. Cancer Lett (2012) 0.78
Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model. PLoS One (2014) 0.78
Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells. Stem Cells Dev (2014) 0.77
[Phosphoinositide 3-kinase (PI3-K) expression. Tumorigenesis of epithelial carcinoma of the mouth]. Pathologe (2004) 0.77
VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway. Tumour Biol (2016) 0.76
Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms. Cancer Biol Ther (2015) 0.75
PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells. Transl Oncol (2014) 0.75
Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells. Mol Cell Proteomics (2013) 0.75
Long non-coding RNA HOTAIR enhances radioresistance in MDA-MB231 breast cancer cells. Oncol Lett (2017) 0.75
Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells. Oncol Lett (2017) 0.75
Program Death-1 Suppresses Autoimmune Arthritis by Inhibiting Th17 Response. Arch Immunol Ther Exp (Warsz) (2016) 0.75
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature (2000) 7.66
Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc Natl Acad Sci U S A (1988) 7.48
Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes. Proc Natl Acad Sci U S A (1986) 6.94
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 6.26
PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet (1999) 6.18
Use of a journal club and letter-writing exercise to teach critical appraisal to medical undergraduates. Med Educ (2001) 5.19
The relation of the animal cell to electrolytes: I. A physiological study of the egg of the trout. J Physiol (1920) 3.62
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A (2000) 3.61
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol (2000) 3.57
Molecular basis of valine resistance in Escherichia coli K-12. Proc Natl Acad Sci U S A (1981) 3.55
Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: re-examination of the English case-control Infectious Intestinal Disease Study (1993-1996). Eur J Clin Microbiol Infect Dis (2007) 3.50
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res (1997) 3.38
Life expectancy in the Marfan syndrome. Am J Cardiol (1995) 3.14
The effect of the doctor's sex on the doctor-patient relationship. J R Coll Gen Pract (1982) 3.12
Sequence diversity of small, round-structured viruses in the Norwalk virus group. J Virol (1994) 3.11
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet (1996) 3.00
Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res (1986) 2.74
A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer (2008) 2.63
Nosocomial infection with Rhizopus microsporus in preterm infants: association with wooden tongue depressors. Lancet (1996) 2.62
The lymphocyte transformation test for the diagnosis of Lyme borreliosis has currently not been shown to be clinically useful. Clin Microbiol Infect (2014) 2.62
Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci U S A (1989) 2.61
Interrelationships of myeloid and lymphoid cells: studies with chromosome-marked cells transfused into lethally irradiated mice. Proc R Soc Lond B Biol Sci (1966) 2.54
CA 125: the past and the future. Int J Biol Markers (1999) 2.50
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci (2002) 2.43
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev (1995) 2.41
The role of betamethasone in the treatment of acute exudative pharyngitis. Acad Emerg Med (1998) 2.29
Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. J Natl Cancer Inst (2001) 2.27
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res (2001) 2.25
Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect (2011) 2.23
Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery. Ann Rheum Dis (2001) 2.21
Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ (2010) 2.17
Exosmosis from animal cells. J Physiol (1921) 2.14
Why do women attend familial breast cancer clinics? J Med Genet (2000) 2.13
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene (1999) 2.07
Reassortment in vivo: driving force for diversity of human rotavirus strains isolated in the United Kingdom between 1995 and 1999. J Virol (2001) 2.06
Consciousness on the scientific agenda. Nature (1992) 2.06
Polydactyly and psychosis. Five cases of co-occurrence. Br J Psychiatry (1998) 2.02
Evaluation of four real-time PCR assays for detection of influenza A(H1N1)v viruses. Euro Surveill (2009) 2.01
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc Natl Acad Sci U S A (1999) 2.00
Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev (1997) 2.00
A survey of injuries to the anterior cruciate ligament of the knee in female basketball players. Int J Sports Med (1985) 1.96
Bacterial endocarditis in England in the 1970's: a review of 70 patients. Q J Med (1977) 1.95
An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids Res (1991) 1.94
The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type. Br J Psychiatry (1989) 1.94
How to boost the odds of a painless i.v. start. Am J Nurs (1992) 1.93
Saccades in presymptomatic and early stages of Huntington disease. Neurology (2006) 1.92
Randomized trial of a specialist genetic assessment service for familial breast cancer. J Natl Cancer Inst (2000) 1.92
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science (1990) 1.90
Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am J Pathol (1998) 1.90
Comparison of angioplasty and surgery for unoperated coarctation of the aorta. Circulation (1993) 1.88
Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer (2010) 1.85
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem (2001) 1.82
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene (1999) 1.81
An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res (2000) 1.81
Analysis of integrated virological and epidemiological reports of norovirus outbreaks collected within the Foodborne Viruses in Europe network from 1 July 2001 to 30 June 2006. J Clin Microbiol (2008) 1.80
Genetic analysis of early- versus late-stage ovarian tumors. Cancer Res (2001) 1.77
Lysophospholipids activate ovarian and breast cancer cells. Biochem J (1995) 1.76
Transmembrane ion fluxes during activation of human T lymphocytes: role of Ca2+, Na+/H+ exchange and phospholipid turnover. Immunol Rev (1987) 1.74
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
Massive edema of the ovary simulating fibroma. Obstet Gynecol (1969) 1.71
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc Natl Acad Sci U S A (1994) 1.70
Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome. Proc Natl Acad Sci U S A (1988) 1.69
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann N Y Acad Sci (2000) 1.67
Adjuvant-induced polyarthritis in rats: biologic and histologic background. Am J Vet Res (1965) 1.66
Effect of cognitive-behavioural training on job-finding among long-term unemployed people. Lancet (1997) 1.64
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab (1996) 1.64
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer (2012) 1.64
Differences in duration of Huntington's disease based on age at onset. J Neurol Neurosurg Psychiatry (1999) 1.63
An ELISA test for the detection of antibodies to Legionella pneumophila. J Clin Pathol (1982) 1.62
Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Res (1998) 1.61
Contamination of environmental surfaces by genital human papillomaviruses. Sex Transm Infect (2002) 1.60
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Mol Cell Neurosci (2001) 1.58
Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res (1995) 1.57
EVALUATE hysterectomy trial: a multicentre randomised trial comparing abdominal, vaginal and laparoscopic methods of hysterectomy. Health Technol Assess (2004) 1.56
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol (2001) 1.56
Markedly elevated levels of vascular endothelial growth factor in malignant ascites. Ann Surg Oncol (1999) 1.54
Reproductive endocrine and endometrial effects of raloxifene hydrochloride, a selective estrogen receptor modulator, in women with regular menstrual cycles. J Clin Endocrinol Metab (1998) 1.54
Primary biliary cirrhosis once rare, now common in the United Kingdom? Hepatology (1999) 1.52
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res (1998) 1.52
The world-wide telescope. Science (2001) 1.51
European Union Concerted Action on Risk Assessment in Lyme Borreliosis: clinical case definitions for Lyme borreliosis. Wien Klin Wochenschr (1996) 1.51
Antigen-induced Ca2+ signaling and desensitization in B cells. J Immunol (1990) 1.50
Mechanical factors in the excitation of clupeid lateral lines. Proc R Soc Lond B Biol Sci (1983) 1.50
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene (2011) 1.49
Breast adenomas. Cancer (1976) 1.49
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem (1999) 1.48
Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype. J Clin Microbiol (2001) 1.44
Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. Cancer Res (1993) 1.44
Clostridium difficile and its toxin in healthy neonates. Br Med J (Clin Res Ed) (1983) 1.44
Physiologic and pathologic drug resistance in ovarian carcinoma--a hypothesis based on a clonal progression model. Acta Oncol (1998) 1.43
Decreased spinal mineral content in amenorrheic women. JAMA (1984) 1.43
Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int J Radiat Biol (1992) 1.43
Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan-European collaborative strain surveillance network. Epidemiol Infect (2010) 1.42
Early silurian spore tetrads from new york: earliest new world evidence for vascular plants? Science (1971) 1.41
Fluorescence in situ hybridization to interphase cell nuclei in suspension allows flow cytometric analysis of chromosome content and microscopic analysis of nuclear organization. Hum Genet (1988) 1.41
Detection of aneuploidy involving chromosomes 13, 18, or 21, by fluorescence in situ hybridization (FISH) to interphase and metaphase amniocytes. Am J Hum Genet (1991) 1.41
Cost-effectiveness of rapid tests and other existing strategies for screening and management of early-onset group B streptococcus during labour. BJOG (2010) 1.41
Epithelioid trophoblastic tumor of the uterus in a postmenopausal woman: a case report and review of the literature. Am J Surg Pathol (2000) 1.41