Snail: More than EMT.

EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med (2011) 2.46

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63

Cranial neural crest cells on the move: their roles in craniofacial development. Am J Med Genet A (2010) 1.55

The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol (2011) 1.40

Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. J Exp Clin Cancer Res (2014) 1.39

Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer. PLoS One (2013) 1.31

The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal (2010) 1.26

Epithelial-mesenchymal transition in cervical carcinoma. Am J Transl Res (2012) 1.15

Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J Cancer (2011) 1.14

Epithelial-mesenchymal transition in ovarian carcinoma. Front Oncol (2012) 1.07

Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. Dev Biol (2011) 0.99

P38/NF-κB/snail pathway is involved in caffeic acid-induced inhibition of cancer stem cells-like properties and migratory capacity in malignant human keratinocyte. PLoS One (2013) 0.98

Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells. Breast Cancer Res (2013) 0.96

G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget (2015) 0.95

Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res (2013) 0.95

A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Mol Cell (2014) 0.94

Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol (2012) 0.93

Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation. Nat Commun (2013) 0.90

Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. Development (2014) 0.90

DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis. Oncogenesis (2015) 0.87

Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol (2011) 0.87

An axis involving SNAI1, microRNA-128 and SP1 modulates glioma progression. PLoS One (2014) 0.85

Snail interacts with Id2 in the regulation of TNF-α-induced cancer cell invasion and migration in OSCC. Am J Cancer Res (2015) 0.84

Snail destabilizes cell surface Crumbs3a. Traffic (2012) 0.83

Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment. J Cancer (2016) 0.83

Snail1 expression in colorectal cancer and its correlation with clinical and pathological parameters. BMC Cancer (2013) 0.83

Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. Cell Cycle (2014) 0.82

FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther (2015) 0.81

Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation. J Exp Clin Cancer Res (2015) 0.81

Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics. Redox Biol (2015) 0.81

Snai1 is important for avian epicardial cell transformation and motility. Dev Dyn (2013) 0.81

Anoikis and EMT: Lethal "Liaisons" during Cancer Progression. Crit Rev Oncog (2016) 0.81

Human NUMB6 Induces Epithelial-Mesenchymal Transition and Enhances Breast Cancer Cells Migration and Invasion. J Cell Biochem (2016) 0.79

Roles Each of Snail, Yin Yang 1 and RKIP in the Regulation of Tumor Cells Chemo-immuno-resistance to Apoptosis. For Immunopathol Dis Therap (2013) 0.78

Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity. Oncotarget (2016) 0.77

The exposure of breast cancer cells to fulvestrant and tamoxifen modulates cell migration differently. Biomed Res Int (2013) 0.77

Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma. Oncotarget (2016) 0.77

Functional analysis of the mRNA profile of neutrophil gelatinase‑associated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools. Mol Med Rep (2014) 0.77

Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development. Int J Biol Sci (2015) 0.77

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression. Oncotarget (2015) 0.77

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget (2016) 0.77

ALX1 promotes migration and invasion of lung cancer cells through increasing snail expression. Int J Clin Exp Pathol (2015) 0.76

Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix. Cell Death Dis (2013) 0.76

Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7. Clin Epigenetics (2016) 0.76

Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem (2015) 0.76

Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes. Front Oncol (2016) 0.76

Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and Snail. For Immunopathol Dis Therap (2012) 0.76

High Vimentin Expression Associated with Lymph Node Metastasis and Predicated a Poor Prognosis in Oral Squamous Cell Carcinoma. Sci Rep (2016) 0.75

The RNA-binding protein ESRP1 promotes human colorectal cancer progression. Oncotarget (2016) 0.75

HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail. Mol Cancer (2016) 0.75

HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma. Nat Commun (2017) 0.75

Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility. PLoS One (2015) 0.75

Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. J Biol Chem (2016) 0.75

Effects of irradiation on radioresistance, HOTAIR and epithelial-mesenchymal transition/cancer stem cell marker expression in esophageal squamous cell carcinoma. Oncol Lett (2017) 0.75

BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research. Sci Rep (2016) 0.75

Tissue-Specific Expression Patterns of MicroRNA during Acute Graft-versus-Host Disease in the Rat. Front Immunol (2016) 0.75

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80

Cancer stem cells. N Engl J Med (2006) 9.63

Socializing with the neighbors: stem cells and their niche. Cell (2004) 9.40

The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42

The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell (2005) 5.81

Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24

The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol (2001) 4.80

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55

Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A (2008) 4.20

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol (2004) 4.15

Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol (2005) 3.30

Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells (2009) 3.25

Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell (2009) 3.22

Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem (2005) 3.03

Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol (2005) 2.88

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol (2004) 2.80

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev (1992) 2.76

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71

Expression of Snail protein in tumor-stroma interface. Oncogene (2006) 2.68

Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48

Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol (2003) 2.46

Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene (2004) 2.44

Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature (2004) 2.36

Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal (2005) 2.17

Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res (2005) 2.09

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99

The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers. Development (1991) 1.81

Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68

Alterations in vascular gene expression in invasive breast carcinoma. Cancer Res (2004) 1.68

Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res (2008) 1.48

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. J Clin Invest (2008) 1.36

Neural stem cell transcriptional networks highlight genes essential for nervous system development. EMBO J (2009) 1.31

Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther (2004) 1.21

Cancer development induced by graded expression of Snail in mice. Hum Mol Genet (2005) 1.18

Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res (2008) 1.14

The Snail repressor is required for PMC ingression in the sea urchin embryo. Development (2007) 1.05

Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers. Urol Oncol (2009) 1.00

Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J (2009) 1.00

Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. J Gastrointest Surg (2009) 0.96

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell (2004) 4.17

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (2005) 3.80

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32

beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell (2002) 2.33

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer (2011) 2.14

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04

New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai) (2008) 1.94

Inflammation: a driving force speeds cancer metastasis. Cell Cycle (2009) 1.78

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res (2004) 1.76

Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis (2008) 1.64

A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res (2005) 1.41

Small C-terminal domain phosphatase enhances snail activity through dephosphorylation. J Biol Chem (2008) 1.31

Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer (2010) 1.26

PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. Anticancer Res (2009) 1.17

Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst (2012) 1.15

Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J Cancer (2011) 1.14

LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling. PLoS One (2011) 1.12

RORα suppresses breast tumor invasion by inducing SEMA3F expression. Cancer Res (2012) 1.04

Enhancement of Bik antitumor effect by Bik mutants. Cancer Res (2003) 1.03

The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells. Cell Rep (2013) 0.97

CD151 represses mammary gland development by maintaining the niches of progenitor cells. Cell Cycle (2014) 0.78

FBW7-Aurora B-p53 feedback loop regulates mitosis and cell growth. Cell Cycle (2012) 0.77

Kinases meet at TSC. Cell Res (2007) 0.76

The Role of Stromal Components in Pancreatic Cancer Progression. Anticancer Agents Med Chem (2016) 0.75

The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions. Anticancer Agents Med Chem (2016) 0.75