Published in Dev Biol on September 05, 2011
Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol (2013) 1.07
Atrioventricular valve development: new perspectives on an old theme. Differentiation (2012) 0.98
A conserved role for Snail as a potentiator of active transcription. Genes Dev (2014) 0.97
Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell (2016) 0.96
MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer. Int J Clin Exp Pathol (2014) 0.92
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. Cancer Res (2013) 0.88
Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos. Sci Rep (2014) 0.82
Snai1 is important for avian epicardial cell transformation and motility. Dev Dyn (2013) 0.81
A Snail1/Notch1 signalling axis controls embryonic vascular development. Nat Commun (2014) 0.79
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Isolation of murine valve endothelial cells. J Vis Exp (2014) 0.76
Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells. J Dev Biol (2013) 0.75
Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis. Int J Clin Exp Pathol (2015) 0.75
MT2-MMP expression during early avian morphogenesis. Anat Rec (Hoboken) (2012) 0.75
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The incidence of congenital heart disease. J Am Coll Cardiol (2002) 16.13
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol (2000) 15.78
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The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci (2003) 6.24
The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol (2001) 4.80
Heart valve development: endothelial cell signaling and differentiation. Circ Res (2004) 4.41
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci (2003) 3.79
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3. J Cell Biol (2000) 3.53
Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation (2001) 3.47
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem (2002) 3.18
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem (2001) 3.03
Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res (2006) 2.91
Cell biology of cardiac cushion development. Int Rev Cytol (2005) 2.75
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Heart valve development: regulatory networks in development and disease. Circ Res (2009) 2.41
Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue. Dev Biol (1983) 2.25
Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol (2008) 2.21
The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol (1998) 2.13
Lineage and morphogenetic analysis of the cardiac valves. Circ Res (2004) 2.06
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem J (2006) 2.03
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn (2004) 1.96
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc Natl Acad Sci U S A (2009) 1.84
Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol (2005) 1.69
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol (2007) 1.67
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology (2011) 1.67
Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Dev Biol (2006) 1.65
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest (2010) 1.54
Snail: More than EMT. Cell Adh Migr (2010) 1.53
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Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci (2004) 1.50
Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture system. Dev Biol (1982) 1.49
Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression. Dev Biol (2006) 1.49
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev Cell (2009) 1.46
BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells. Dev Biol (2006) 1.46
Multiple functions of Snail family genes during palate development in mice. Development (2007) 1.45
Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res (2010) 1.30
Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton. Dev Dyn (2003) 1.28
Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. Mol Cell Biol (2001) 1.25
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. Neoplasia (2009) 1.22
Degradation of type IV collagen by matrix metalloproteinases is an important step in the epithelial-mesenchymal transformation of the endocardial cushions. Dev Biol (2000) 1.20
Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. J Cell Biochem (2009) 1.18
BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis. Dev Biol (2007) 1.17
Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol (2001) 1.16
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem (2003) 1.15
Myocardial specificity for initiating endothelial-mesenchymal cell transition in embryonic chick heart correlates with a particulate distribution of fibronectin. Dev Biol (1987) 1.15
Generation of a Snail1 (Snai1) conditional null allele. Genesis (2006) 1.14
Slug is a mediator of epithelial-mesenchymal cell transformation in the developing chicken heart. Dev Biol (1999) 1.13
Matrix metalloproteinase 2-integrin alpha(v)beta3 binding is required for mesenchymal cell invasive activity but not epithelial locomotion: a computational time-lapse study. Mol Biol Cell (2008) 1.05
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Dev Dyn (2008) 1.04
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist. Biochem Biophys Res Commun (2004) 1.02
Akt promotes endocardial-mesenchyme transition. J Angiogenes Res (2009) 0.99
Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis. Z Kardiol (2004) 0.97
Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes (2009) 0.95
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. J Cell Biol (2008) 0.94
Congenital heart defects: trapping the genetic culprits. Circ Res (2000) 0.87
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res (2006) 2.91
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet (2006) 2.56
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev (2005) 1.81
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev (2003) 1.76
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci (2006) 1.65
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood (2010) 1.60
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A (2006) 1.58
Generation of new Notch2 mutant alleles. Genesis (2006) 1.56
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration. J Biol Chem (2002) 1.50
Multiple functions of Snail family genes during palate development in mice. Development (2007) 1.45
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn (2006) 1.37
Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ Res (2008) 1.30
Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res (2010) 1.30
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest (2011) 1.29
Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 1.27
TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol (2003) 1.24
Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis (2010) 1.20
The developmental transcription factor slug is widely expressed in tissues of adult mice. J Histochem Cytochem (2004) 1.20
Cell movements during gastrulation: snail dependent and independent pathways. Curr Opin Genet Dev (2002) 1.16
Generation of a Snail1 (Snai1) conditional null allele. Genesis (2006) 1.14
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis (2002) 1.14
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development (2010) 1.10
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol (2013) 1.09
Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome. Anat Rec (2002) 1.09
Role of the Notch signalling pathway in tooth morphogenesis. Arch Oral Biol (2004) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Molecular pathways of notch signaling in vascular smooth muscle cells. Front Physiol (2012) 1.07
Notch signaling coordinates the patterning of striatal compartments. Development (2005) 1.05
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Dev Dyn (2008) 1.04
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Hum Mol Genet (2007) 1.04
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist. Biochem Biophys Res Commun (2004) 1.02
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet (2012) 1.02
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. J Exp Med (2013) 1.00
Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A (2012) 0.99
Laser surgery for mouse geneticists. Nat Biotechnol (2007) 0.97
Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes (2009) 0.95
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res (2013) 0.95
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. Dev Biol (2007) 0.95
Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics (2006) 0.95
Slug expression during organogenesis in mice. Anat Rec A Discov Mol Cell Evol Biol (2003) 0.92
BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development (2010) 0.92
Snail1 gene function during early embryo patterning in mice. Cell Cycle (2006) 0.92
Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles. BMC Biol (2013) 0.91
Heart valve development, maintenance, and disease: the role of endothelial cells. Curr Top Dev Biol (2012) 0.91
Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol (2007) 0.90
Myocardial alternative RNA splicing and gene expression profiling in early stage hypoplastic left heart syndrome. PLoS One (2012) 0.89
Generation of mice with a conditional null allele of the Jagged2 gene. Genesis (2010) 0.89
Mutations in snail family genes enhance craniosynostosis of Twist1 haplo-insufficient mice: implications for Saethre-Chotzen Syndrome. Genetics (2005) 0.88
The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis. Biochem Biophys Res Commun (2013) 0.87
Differential changes in TGF-β/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome. J Card Fail (2010) 0.87
Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice. Genetics (2007) 0.86
Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev Biol (2002) 0.86
Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Dev Dyn (2002) 0.86
Notch Signaling during Oogenesis in Drosophila melanogaster. Genet Res Int (2012) 0.85
Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn (2010) 0.85
The snail family gene snai3 is not essential for embryogenesis in mice. PLoS One (2013) 0.83
Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol (2012) 0.83
Vascular biology: vessel guidance. Nature (2007) 0.83
Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves. J Mol Cell Cardiol (2013) 0.83
Collagen XIV is important for growth and structural integrity of the myocardium. J Mol Cell Cardiol (2012) 0.82
Jagged1-mediated Notch signaling regulates mammalian inner ear development independent of lateral inhibition. Acta Otolaryngol (2012) 0.81
Snai1 is important for avian epicardial cell transformation and motility. Dev Dyn (2013) 0.81
The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis (2012) 0.79
Cost-benefit analysis of robotic versus nonrobotic minimally invasive mitral valve surgery. Innovations (Phila) (2015) 0.79
Genetics of valvular heart disease. Curr Cardiol Rep (2014) 0.77
Genetic basis of aortic valvular disease. Curr Opin Cardiol (2017) 0.77
Is aviation a good model to study human errors in health care? Am J Surg (2011) 0.76
Not all lunatic fringe null female mice are infertile. Development (2006) 0.75
Absence of a major role for the snai1 and snai3 genes in regulating skeletal muscle regeneration in mice. PLoS Curr (2013) 0.75
Minimally Invasive Aortic Valve Replacement: Cost-Benefit Analysis of Ministernotomy Versus Minithoracotomy Approach. J Heart Valve Dis (2015) 0.75