Published in PLoS Pathog on February 12, 2010
On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp. PC1. BMC Biol (2016) 1.43
Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins. PLoS Pathog (2015) 1.43
Drosophila as a model system to unravel the layers of innate immunity to infection. Open Biol (2012) 1.20
Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun (2012) 1.07
Transfer of Immunity from Mother to Offspring Is Mediated via Egg-Yolk Protein Vitellogenin. PLoS Pathog (2015) 1.02
Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. Curr Biol (2013) 1.01
Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. J Innate Immun (2010) 0.98
Tocilizumab induced acquired factor XIII deficiency in patients with rheumatoid arthritis. PLoS One (2013) 0.97
Variation in the susceptibility of Drosophila to different entomopathogenic nematodes. Infect Immun (2015) 0.90
Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila. PLoS One (2010) 0.89
Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer. Front Cell Infect Microbiol (2014) 0.87
Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin. PLoS Pathog (2012) 0.86
Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq. BMC Genomics (2015) 0.86
Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate. PLoS One (2011) 0.84
A novel method for infecting Drosophila adult flies with insect pathogenic nematodes. Virulence (2012) 0.83
A pathogenic nematode targets recognition proteins to avoid insect defenses. PLoS One (2013) 0.82
Host response to respiratory bacterial pathogens as identified by integrated analysis of human gene expression data. PLoS One (2013) 0.82
The Drosophila melanogaster host model. J Oral Microbiol (2012) 0.82
Damage signals in the insect immune response. Front Plant Sci (2014) 0.82
Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate Plugin. J Biol Chem (2013) 0.81
An improved method for nematode infection assays in Drosophila larvae. Fly (Austin) (2012) 0.81
Thorax injury lowers resistance to infection in Drosophila melanogaster. Infect Immun (2014) 0.80
A serpin released by an entomopathogen impairs clot formation in insect defense system. PLoS One (2013) 0.80
Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway. J Evol Biol (2015) 0.80
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae. J Biol Chem (2013) 0.80
The role of coagulation/fibrinolysis during Streptococcus pyogenes infection. Front Cell Infect Microbiol (2014) 0.80
Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3. Malar J (2014) 0.78
The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation. Mol Microbiol (2014) 0.78
The amphioxus genome provides unique insight into the evolution of immunity. Brief Funct Genomics (2012) 0.78
Matrix expansion and syncytial aggregation of syndecan-1+ cells underpin villous atrophy in coeliac disease. PLoS One (2014) 0.78
Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity. Front Microbiol (2017) 0.77
Conservation of the Host-Interacting Proteins Tp0750 and Pallilysin among Treponemes and Restriction of Proteolytic Capacity to Treponema pallidum. Infect Immun (2015) 0.77
Transcriptional response of Musca domestica larvae to bacterial infection. PLoS One (2014) 0.77
TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster. Immunobiology (2016) 0.76
Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus. Sci Rep (2015) 0.76
RNAseq Analysis of the Drosophila Response to the Entomopathogenic Nematode Steinernema. G3 (Bethesda) (2017) 0.75
Bombyx mori and Aedes aegypti form multi-functional immune complexes that integrate pattern recognition, melanization, coagulants, and hemocyte recruitment. PLoS One (2017) 0.75
Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics (2017) 0.75
Transglutaminase-catalyzed incorporation of polyamines masks the DNA-binding region of the transcription factor Relish. J Biol Chem (2017) 0.75
Shrimp alpha-2-macroglobulin prevents the bacterial escape by inhibiting fibrinolysis of blood clots. PLoS One (2012) 0.75
Recent Advances in Celiac Disease. Indian J Pediatr (2016) 0.75
Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective. Sci Rep (2016) 0.75
Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes. J Gastroenterol (2015) 0.75
Monitoring the effect of pathogenic nematodes on locomotion of Drosophila larvae. Fly (Austin) (2017) 0.75
Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol (2003) 6.05
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science (2004) 2.91
Antimicrobial defense and persistent infection in insects. Science (2008) 2.73
A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol (2008) 2.45
Coagulation in arthropods: defence, wound closure and healing. Trends Immunol (2004) 1.99
JNK signaling pathway is required for efficient wound healing in Drosophila. Dev Biol (2002) 1.97
Twin intromittent organs of Drosophila for traumatic insemination. Biol Lett (2007) 1.89
An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition. Proc Natl Acad Sci U S A (2007) 1.64
Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. Crit Care (2002) 1.59
The interaction between pathogens and the host coagulation system. Physiology (Bethesda) (2006) 1.58
The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes. Proc Natl Acad Sci U S A (2003) 1.51
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. EMBO Rep (2006) 1.49
Nematodes, bacteria, and flies: a tripartite model for nematode parasitism. Curr Biol (2007) 1.42
Activation of the human contact system on neutrophil extracellular traps. J Innate Immun (2009) 1.41
Immune system responses and fitness costs associated with consumption of bacteria in larvae of Trichoplusia ni. BMC Biol (2007) 1.40
Innate immunity and its evasion and suppression by hymenopteran endoparasitoids. Bioessays (2001) 1.37
Models of infectious diseases in the fruit fly Drosophila melanogaster. Dis Model Mech (2008) 1.24
Proteomic analysis of the Drosophila larval hemolymph clot. J Biol Chem (2004) 1.19
Hemolymph coagulation and phenoloxidase in Drosophila larvae. Dev Comp Immunol (2005) 1.18
Role of fibrin deposition in the pathogenesis of intraabdominal infection. Eur J Clin Microbiol Infect Dis (1992) 1.14
Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method. Curr Biol (2004) 1.14
A role for Hemolectin in coagulation and immunity in Drosophila melanogaster. Dev Comp Immunol (2007) 1.09
The coagulation of insect hemolymph. Cell Mol Life Sci (2002) 0.98
The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation. Dev Biol (2006) 0.95
Activation of TAFI on the surface of Streptococcus pyogenes evokes inflammatory reactions by modulating the kallikrein/kinin system. J Innate Immun (2008) 0.93
The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila. Biochem Biophys Res Commun (2005) 0.93
Carriership of Factor V Leiden and evolutionary selection advantage. Curr Med Chem (2008) 0.91
Characterization of hemolytic and cytotoxic Gallysins: a relationship with arylphorins. Dev Comp Immunol (1997) 0.90
Fondue and transglutaminase in the Drosophila larval clot. J Insect Physiol (2007) 0.90
A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites. J Biol Chem (2007) 0.89
The granular cells of Galleria mellonella during clotting and phagocytic reactions in vitro. Tissue Cell (1976) 0.87
Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies. Crit Care Med (2004) 0.84
A nematode symbiont sheds light on invertebrate immunity. Trends Parasitol (2007) 0.82
Identification, purification and properties of a beta-1,3-glucan-specific lectin from the serum of the cockroach, Blaberus discoidalis which is implicated in immune defence reactions. Comp Biochem Physiol B Biochem Mol Biol (1999) 0.81
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99
M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Cell (2004) 2.46
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem (2002) 2.44
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A (2013) 2.32
Antibody orientation at bacterial surfaces is related to invasive infection. J Exp Med (2012) 2.30
Pathogenic mechanisms in lupus nephritis: Nucleosomes bind aberrant laminin β1 with high affinity and colocalize in the electron-dense deposits. Arthritis Rheumatol (2014) 2.13
Neutrophil secretion products pave the way for inflammatory monocytes. Blood (2008) 2.12
Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. Blood (2010) 2.04
Heparin-binding protein: an early marker of circulatory failure in sepsis. Clin Infect Dis (2009) 1.94
Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense. Blood (2011) 1.87
Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem (2013) 1.84
Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model. Am J Pathol (2008) 1.77
β₂-glycoprotein I: a novel component of innate immunity. Blood (2011) 1.75
COMP acts as a catalyst in collagen fibrillogenesis. J Biol Chem (2007) 1.74
Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J Biol Chem (2003) 1.72
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J (2003) 1.67
Insect resistance to Bacillus thuringiensis: alterations in the indianmeal moth larval gut proteome. Mol Cell Proteomics (2003) 1.62
The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem (2005) 1.61
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A (2011) 1.52
Activation of the complement system generates antibacterial peptides. Proc Natl Acad Sci U S A (2004) 1.51
Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. Hum Mol Genet (2004) 1.51
Antimicrobial activities of heparin-binding peptides. Eur J Biochem (2004) 1.46
Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheep. Shock (2010) 1.44
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J Cell Sci (2007) 1.44
Activation of the human contact system on neutrophil extracellular traps. J Innate Immun (2009) 1.41
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The contact system--a novel branch of innate immunity generating antibacterial peptides. EMBO J (2006) 1.36
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol (2006) 1.36
Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures. J Biol Chem (2002) 1.35
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem (2009) 1.31
Streptococcus pyogenes expressing M and M-like surface proteins are phagocytosed but survive inside human neutrophils. Cell Microbiol (2003) 1.29
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. J Clin Invest (2008) 1.25
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum (2010) 1.23
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metab (2009) 1.22
Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro. J Biol Chem (2002) 1.22
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol (2008) 1.21
Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma. Proc Natl Acad Sci U S A (2007) 1.20
Proteomic analysis of the Drosophila larval hemolymph clot. J Biol Chem (2004) 1.19
Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages. Mech Dev (2002) 1.18
Hemolymph coagulation and phenoloxidase in Drosophila larvae. Dev Comp Immunol (2005) 1.18
Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med (2012) 1.18
Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood (2002) 1.18
Activation of insect phenoloxidase after injury: endogenous versus foreign elicitors. J Innate Immun (2008) 1.15
Molecular consequences of dominant Bethlem myopathy collagen VI mutations. Ann Neurol (2007) 1.15
Collagen VI glycine mutations: perturbed assembly and a spectrum of clinical severity. Ann Neurol (2008) 1.14
Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method. Curr Biol (2004) 1.14
Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins. Structure (2004) 1.14
A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Cancer Res (2005) 1.13
Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog (2010) 1.12
Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions. Biochim Biophys Acta (2007) 1.12
Domain 5 of high molecular weight kininogen is antibacterial. J Biol Chem (2005) 1.11
The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Development (2002) 1.11
Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura. Br J Haematol (2007) 1.11
B cell activation by outer membrane vesicles--a novel virulence mechanism. PLoS Pathog (2010) 1.09
A role for Hemolectin in coagulation and immunity in Drosophila melanogaster. Dev Comp Immunol (2007) 1.09
Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coli. J Biol Chem (2002) 1.09
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Lett (2011) 1.09
Antimicrobial peptides derived from growth factors. Growth Factors (2007) 1.09
Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. PLoS One (2012) 1.08
The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem (2002) 1.08
Streptococcus pyogenes bacteria modulate membrane traffic in human neutrophils and selectively inhibit azurophilic granule fusion with phagosomes. Cell Microbiol (2006) 1.06
Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias. J Biol Chem (2006) 1.06
Contact system activation in severe infectious diseases. J Mol Med (Berl) (2010) 1.06
Kinked collagen VI tetramers and reduced microfibril formation as a result of Bethlem myopathy and introduced triple helical glycine mutations. J Biol Chem (2001) 1.06
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J Immunol (2008) 1.05
Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein. J Biol Chem (2004) 1.05
Streptococcal M proteins and their role as virulence determinants. Clin Chim Acta (2010) 1.05
Presence of activated mobile fibroblasts in bronchoalveolar lavage from patients with mild asthma. Am J Respir Crit Care Med (2004) 1.05
The dual role of the contact system in bacterial infectious disease. Thromb Haemost (2007) 1.05
Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin. Antimicrob Agents Chemother (2011) 1.05
The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils. J Lipid Res (2011) 1.05
Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila. Dev Biol (2011) 1.04
Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens. J Innate Immun (2009) 1.04
Boosting antimicrobial peptides by hydrophobic oligopeptide end tags. J Biol Chem (2009) 1.03
Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis. J Innate Immun (2010) 1.03
All four members of the Ten-m/Odz family of transmembrane proteins form dimers. J Biol Chem (2002) 1.03
Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix. J Immunol (2009) 1.03
C-terminal peptides of tissue factor pathway inhibitor are novel host defense molecules. J Biol Chem (2010) 1.02
Clotting factors and eicosanoids protect against nematode infections. J Innate Immun (2010) 1.02
The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. Antimicrob Agents Chemother (2008) 1.01
Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol (2010) 1.01
Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins? J Innate Immun (2010) 1.01
ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican. J Biol Chem (2009) 1.01
Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol (2005) 1.00
Role of adhesion in arthropod immune recognition. Annu Rev Entomol (2010) 1.00