Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax.

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Published in PLoS Pathog on February 19, 2010

Authors

Jiraprapa Wipasa1, Chaisuree Suphavilai, Lucy C Okell, Jackie Cook, Patrick H Corran, Kanitta Thaikla, Witaya Liewsaree, Eleanor M Riley, Julius Clemence R Hafalla

Author Affiliations

1: Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.

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Regulatory T cells in malaria--friend or foe? Trends Immunol (2010) 1.02

Assessing malaria transmission in a low endemicity area of north-western Peru. Malar J (2013) 1.02

Human immune responses that reduce the transmission of Plasmodium falciparum in African populations. Int J Parasitol (2010) 1.01