Published in Nat Genet on August 12, 2007
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med (2013) 3.41
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
The Yin and Yang of HLA and KIR in human disease. Semin Immunol (2008) 2.72
The shaping of modern human immune systems by multiregional admixture with archaic humans. Science (2011) 2.63
Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet (2008) 2.58
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Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. J Exp Med (2009) 1.99
Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature (2011) 1.94
The extensive polymorphism of KIR genes. Immunology (2010) 1.83
Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis (2012) 1.73
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Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res (2012) 1.60
Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians. Am J Hum Genet (2008) 1.60
Copy number variation of KIR genes influences HIV-1 control. PLoS Biol (2011) 1.44
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res (2009) 1.42
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands. Proc Natl Acad Sci U S A (2009) 1.35
The genetic and evolutionary balances in human NK cell receptor diversity. Semin Immunol (2008) 1.35
Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology (2011) 1.28
Methods for assessing gene content diversity of KIR with examples from a global set of populations. Immunogenetics (2008) 1.22
Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1. J Immunol (2008) 1.19
Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? PLoS Genet (2011) 1.17
Primate-specific regulation of natural killer cells. J Med Primatol (2010) 1.14
Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57. J Virol (2011) 1.14
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Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes. J Immunol (2009) 1.12
Variable NK cell receptors exemplified by human KIR3DL1/S1. J Immunol (2011) 1.12
Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations. Immunogenetics (2012) 1.11
Immunogenetics as a tool in anthropological studies. Immunology (2011) 1.11
A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia. Proc Natl Acad Sci U S A (2015) 1.11
KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families. Immunogenetics (2008) 1.10
Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans. PLoS Genet (2013) 1.08
Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. PLoS Pathog (2012) 1.02
The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities. Immunogenetics (2010) 1.01
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Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors. J Immunol (2009) 0.98
Recombinant structures expand and contract inter and intragenic diversification at the KIR locus. BMC Genomics (2013) 0.98
Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol (2011) 0.97
Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol (2010) 0.95
Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity. J Immunol (2014) 0.94
Structural basis for recognition of cellular and viral ligands by NK cell receptors. Front Immunol (2014) 0.94
Analysis of binding of KIR3DS1*014 to HLA suggests distinct evolutionary history of KIR3DS1. J Immunol (2011) 0.94
Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population. Immunogenetics (2013) 0.93
Review: Immunogenetics of human placentation. Placenta (2011) 0.92
Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry. Genes Immun (2011) 0.91
Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals. J Immunol (2009) 0.91
In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans. Hum Immunol (2009) 0.90
Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. PLoS One (2009) 0.90
Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR. Genome Med (2014) 0.88
Identification and characterisation of a novel immune-type receptor (NITR) gene cluster in the European sea bass, Dicentrarchus labrax, reveals recurrent gene expansion and diversification by positive selection. Immunogenetics (2009) 0.88
Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles. PLoS One (2014) 0.88
Natural killer cells and their receptors in multiple sclerosis. Brain (2012) 0.87
Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet (2016) 0.87
Diversity of the KIR gene cluster in an urban Brazilian population. Immunogenetics (2011) 0.86
Enrichment of variations in KIR3DL1/S1 and KIR2DL2/L3 among H1N1/09 ICU patients: an exploratory study. PLoS One (2011) 0.86
KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol (2016) 0.85
The profile of KIR3DL1 and KIR3DS1 alleles in an African American population resembles that found in African populations. Tissue Antigens (2010) 0.85
Co-evolution of MHC class I and variable NK cell receptors in placental mammals. Immunol Rev (2015) 0.85
KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in malaria infection. Immunogenetics (2010) 0.85
Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. J Exp Med (2016) 0.83
Role of KIR3DS1 in human diseases. Front Immunol (2012) 0.83
KIR gene content in amerindians indicates influence of demographic factors. PLoS One (2013) 0.82
KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand. Immunogenetics (2014) 0.81
Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population. PLoS Genet (2015) 0.81
KIR3DL1 genetic diversity and phenotypic variation in the Chinese Han population. Genes Immun (2013) 0.81
The yin-yang of KIR3DL1/S1: molecular mechanisms and cellular function. Crit Rev Immunol (2013) 0.81
Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3. PLoS Negl Trop Dis (2014) 0.80
KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding. J Immunol (2015) 0.80
HLA class I variation in Iranian Lur and Kurd populations: high haplotype and allotype diversity with an abundance of KIR ligands. HLA (2016) 0.80
African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity. Tissue Antigens (2010) 0.79
Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy. Invest Ophthalmol Vis Sci (2009) 0.79
Killer-cell immunoglobulin-like receptors and malaria caused by Plasmodium falciparum in The Gambia. Tissue Antigens (2012) 0.79
Definition of the cattle killer cell Ig-like receptor gene family: comparison with aurochs and human counterparts. J Immunol (2014) 0.79
KIR and HLA under pressure: evidences of coevolution across worldwide populations. Hum Genet (2015) 0.79
Deciphering the KIR system at super-resolution for NK and T cell biology. Immunology (2016) 0.79
Class I HLA haplotypes form two schools that educate NK cells in different ways. Sci Immunol (2016) 0.79
Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1. Eur J Immunol (2016) 0.78
Cattle Ly49 is polymorphic. Immunogenetics (2009) 0.78
Understanding rare and common diseases in the context of human evolution. Genome Biol (2016) 0.78
Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses. PLoS One (2014) 0.77
In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection. Hum Immunol (2012) 0.76
Natural Killer Cell Diversity in Viral Infection: Why and How Much? Pathog Immun (2016) 0.76
Ancient Genetic Signatures of Orang Asli Revealed by Killer Immunoglobulin-Like Receptor Gene Polymorphisms. PLoS One (2015) 0.76
The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk. J Immunol Res (2016) 0.75
KIR and HLA haplotype analysis in a family lacking the KIR 2DL1-2DP1 genes. Balkan J Med Genet (2015) 0.75
Living in an adaptive world: Genomic dissection of the genus Homo and its immune response. J Exp Med (2017) 0.75
Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Gene Regul Syst Bio (2016) 0.75
Killer Immunoglobulin-Like Receptor Allele Determination Using Next-Generation Sequencing Technology. Front Immunol (2017) 0.75
NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs. Stem Cell Reports (2017) 0.75
Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles. PLoS Genet (2017) 0.75
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
A human genome diversity cell line panel. Science (2002) 14.11
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
A high-resolution map of transcription in the yeast genome. Proc Natl Acad Sci U S A (2006) 11.81
Empirical analysis of transcriptional activity in the Arabidopsis genome. Science (2003) 11.62
Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36
Whole-genome sequencing and assembly with high-throughput, short-read technologies. PLoS One (2007) 8.70
Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A (2005) 8.65
The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (2008) 8.52
Role of duplicate genes in genetic robustness against null mutations. Nature (2003) 7.81
Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Med (2008) 7.28
Multiplexed genotyping with sequence-tagged molecular inversion probes. Nat Biotechnol (2003) 7.02
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet (2007) 6.83
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A (2004) 6.34
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med (2011) 6.34
Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res (2005) 6.32
IL-10: the master regulator of immunity to infection. J Immunol (2008) 6.11
Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistance. Genome Res (2007) 5.95
Viral population estimation using pyrosequencing. PLoS Comput Biol (2008) 5.89
IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res (2003) 5.64
A pyrosequencing-tailored nucleotide barcode design unveils opportunities for large-scale sample multiplexing. Nucleic Acids Res (2007) 5.33
Dissecting the architecture of a quantitative trait locus in yeast. Nature (2002) 5.24
Microbes on the human vaginal epithelium. Proc Natl Acad Sci U S A (2005) 5.15
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A (2004) 5.10
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics (2005) 5.08
Systematic screen for human disease genes in yeast. Nat Genet (2002) 4.97
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science (2005) 4.74
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59
Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria. JAMA (2005) 4.57
Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood (2010) 4.46
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol (2001) 4.24
Innate immunity to malaria. Nat Rev Immunol (2004) 4.19
Multigene amplification and massively parallel sequencing for cancer mutation discovery. Proc Natl Acad Sci U S A (2007) 3.93
Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol (2003) 3.88
Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania. J Infect Dis (2005) 3.75
Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One (2012) 3.74
A transcriptional profile of aging in the human kidney. PLoS Biol (2004) 3.69
Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity (2005) 3.62
The IMGT/HLA database. Nucleic Acids Res (2012) 3.61
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U S A (2011) 3.53
Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Proc Natl Acad Sci U S A (2007) 3.52
Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function. J Exp Med (2006) 3.50
Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med (2013) 3.41
Multiplex protein assays based on real-time magnetic nanotag sensing. Proc Natl Acad Sci U S A (2008) 3.34
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing. Proc Natl Acad Sci U S A (2007) 3.25
Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A (2009) 3.19
Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia. Blood (2008) 3.18
Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet (2005) 3.09
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol (2007) 3.07
Rapid assessment of malaria transmission using age-specific sero-conversion rates. PLoS One (2009) 2.94
The IMGT/HLA database. Nucleic Acids Res (2010) 2.89
Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res (2006) 2.81
Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial. Lancet Infect Dis (2011) 2.79
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. J Immunol (2008) 2.76
High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci U S A (2010) 2.74
Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci U S A (2002) 2.72
MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood (2008) 2.71
Multiplex amplification of all coding sequences within 10 cancer genes by Gene-Collector. Nucleic Acids Res (2007) 2.70
Metabolic specialization associated with phenotypic switching in Candidaalbicans. Proc Natl Acad Sci U S A (2002) 2.69
Ontology-based meta-analysis of global collections of high-throughput public data. PLoS One (2010) 2.67
Does malaria suffer from lack of memory? Immunol Rev (2004) 2.66
Children and adults with primary antibody deficiencies gain quality of life by subcutaneous IgG self-infusions at home. J Allergy Clin Immunol (2004) 2.65
The shaping of modern human immune systems by multiregional admixture with archaic humans. Science (2011) 2.63
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62
Bacterial flora-typing with targeted, chip-based Pyrosequencing. BMC Microbiol (2007) 2.51
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50
Allele quantification using molecular inversion probes (MIP). Nucleic Acids Res (2005) 2.46
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature. Blood (2007) 2.39
Pyrosequencing: an accurate detection platform for single nucleotide polymorphisms. Hum Mutat (2002) 2.36
Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT. Blood (2007) 2.36
Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet (2005) 2.32
Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol (2004) 2.31
Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. Infect Immun (2004) 2.31
Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax. PLoS Pathog (2010) 2.30
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J Immunol (2007) 2.28
High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25
Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues. J Exp Med (2005) 2.23
Profiling the antibody immune response against blood stage malaria vaccine candidates. Clin Chem (2007) 2.23
The IMGT/HLA database. Nucleic Acids Res (2008) 2.22
An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol (2008) 2.21
Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial Guinea. PLoS One (2011) 2.18
Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes. J Immunol (2002) 2.12
Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 2.09