1
|
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.
|
Curr Med Chem
|
2007
|
1.85
|
2
|
Diversity of folds in animal toxins acting on ion channels.
|
Biochem J
|
2004
|
1.43
|
3
|
Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells.
|
J Biol Chem
|
2003
|
1.22
|
4
|
Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism.
|
J Biol Chem
|
2003
|
1.17
|
5
|
Animal toxins acting on voltage-gated potassium channels.
|
Curr Pharm Des
|
2008
|
1.16
|
6
|
Maurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav 1.1 subunit share common binding sites on the skeletal ryanodine receptor.
|
J Biol Chem
|
2004
|
1.15
|
7
|
K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.
|
Biochem J
|
2005
|
1.11
|
8
|
Resistance of hepatitis C virus to NS3-4A protease inhibitors: mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations.
|
Antivir Ther
|
2006
|
1.10
|
9
|
Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.
|
Biochim Biophys Acta
|
2006
|
1.10
|
10
|
Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane.
|
J Biol Chem
|
2005
|
1.06
|
11
|
Mapping of maurotoxin binding sites on hKv1.2, hKv1.3, and hIKCa1 channels.
|
Mol Pharmacol
|
2004
|
1.02
|
12
|
Protein-protein recognition control by modulating electrostatic interactions.
|
J Proteome Res
|
2010
|
1.00
|
13
|
Design of a disulfide-less, pharmacologically inert, and chemically competent analog of maurocalcine for the efficient transport of impermeant compounds into cells.
|
J Biol Chem
|
2008
|
0.99
|
14
|
The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.
|
Biochem J
|
2004
|
0.98
|
15
|
Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.
|
Biochem J
|
2004
|
0.97
|
16
|
Differential effects of maurocalcine on Ca2+ release events and depolarization-induced Ca2+ release in rat skeletal muscle.
|
J Physiol
|
2005
|
0.97
|
17
|
Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.
|
J Biol Chem
|
2004
|
0.97
|
18
|
The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.
|
J Biol Chem
|
2002
|
0.94
|
19
|
Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels.
|
J Pept Sci
|
2005
|
0.92
|
20
|
Toxin determinants required for interaction with voltage-gated K+ channels.
|
Toxicon
|
2004
|
0.91
|
21
|
Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices.
|
Neurosci Lett
|
2005
|
0.90
|
22
|
Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats.
|
J Physiol
|
2010
|
0.89
|
23
|
Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.
|
Eur J Biochem
|
2003
|
0.88
|
24
|
Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins.
|
J Biol Chem
|
2013
|
0.88
|
25
|
Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region.
|
Cell Mol Life Sci
|
2014
|
0.86
|
26
|
Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain.
|
Mol Pharmacol
|
2005
|
0.86
|
27
|
A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.
|
J Biol Chem
|
2003
|
0.85
|
28
|
Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy.
|
Ann Neurol
|
2006
|
0.84
|
29
|
The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily.
|
Proteins
|
2005
|
0.83
|
30
|
Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro.
|
Biochem J
|
2002
|
0.82
|
31
|
Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1).
|
Toxicon
|
2004
|
0.81
|
32
|
Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine.
|
J Biol Chem
|
2012
|
0.81
|
33
|
Liposomal encapsulation enhances antiviral efficacy of SPC3 against human immunodeficiency virus type-1 infection in human lymphocytes.
|
Antiviral Res
|
2002
|
0.79
|
34
|
Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2 and SKCa3 channels.
|
Peptides
|
2005
|
0.79
|
35
|
Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.
|
Proteins
|
2005
|
0.78
|
36
|
Protein content analysis and antimicrobial activity of the crude venom of Montivipera bornmuelleri; a viper from Lebanon.
|
Infect Disord Drug Targets
|
2014
|
0.78
|
37
|
Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins.
|
Protein Sci
|
2007
|
0.78
|
38
|
Modelling of the III-IV loop, a domain involved in calcium channel Ca(v)2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins.
|
Eur J Neurosci
|
2002
|
0.78
|
39
|
Cell penetration properties of a highly efficient mini maurocalcine Peptide.
|
Pharmaceuticals (Basel)
|
2013
|
0.78
|
40
|
Animal venoms: from deadly arsenals (toxins) to therapeutic drug candidates.
|
Inflamm Allergy Drug Targets
|
2011
|
0.77
|
41
|
The deciphered genome of Mesobuthus martensii uncovers the resistance mysteries of scorpion to its own venom and toxins at the ion channel level.
|
Toxins (Basel)
|
2013
|
0.77
|
42
|
Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel.
|
J Pept Sci
|
2011
|
0.77
|
43
|
CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity.
|
Behav Brain Res
|
2005
|
0.77
|
44
|
Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels.
|
Protein Sci
|
2003
|
0.76
|
45
|
SKCa Channels Blockage Increases the Expression of Adenosine A2A Receptor in Jurkat Human T Cells.
|
Biores Open Access
|
2013
|
0.75
|
46
|
Synthesis, 3-D structure, and pharmacology of a reticulated chimeric peptide derived from maurotoxin and Tsk scorpion toxins.
|
Biochem Biophys Res Commun
|
2002
|
0.75
|
47
|
First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.
|
J Pept Sci
|
2004
|
0.75
|
48
|
Bacteriocins active against multi-resistant gram negative bacteria implicated in nosocomial infections.
|
Infect Disord Drug Targets
|
2015
|
0.75
|
49
|
Drug targets in viral infections.
|
Infect Disord Drug Targets
|
2009
|
0.75
|
50
|
Chemical synthesis and characterization of J46 peptide, an atypical class IIa bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.
|
J Antibiot (Tokyo)
|
2008
|
0.75
|