Published in Am J Hum Genet on May 01, 1991
Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev (2011) 2.22
Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest (1994) 1.40
Role of endothelin-1 in lung disease. Respir Res (2001) 1.36
Physiology of endothelin and the kidney. Compr Physiol (2011) 1.08
Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. Br J Pharmacol (2013) 1.03
Endothelin-1 and the kidney--beyond BP. Br J Pharmacol (2012) 0.88
Different pressor and bronchoconstrictor properties of human big-endothelin-1, 2 (1-38) and 3 in ketamine/xylazine-anaesthetized guinea-pigs. Br J Pharmacol (1995) 0.85
Endothelin antagonists in hypertension and kidney disease. Pediatr Nephrol (2012) 0.82
A genome-wide association study in multiple system atrophy. Neurology (2016) 0.78
Endothelins mediate neutrophil activation, ProMMP-9 release and endothelial cell detachment. Inflammation (2007) 0.77
TaqI polymorphism at the human preproendothelin-1 gene (EDN1). Nucleic Acids Res (1991) 0.75
Endothelin 1 gene is not a major modifier of chronic kidney disease advancement among the autosomal dominant polycystic kidney disease patients. J Nephropharmacol (2015) 0.75
Plasma endothelin-1 and single nucleotide polymorphisms of endothelin-1 and endothelin type A receptor genes as risk factors for normal tension glaucoma. Mol Vis (2016) 0.75
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization. Chromosoma (1981) 9.30
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41
Improved techniques for the induction of mammalian cell hybridization by polyethylene glycol. Somatic Cell Genet (1976) 5.05
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett (1988) 3.96
Structural organization and chromosomal assignment of the gene encoding endothelin. J Biol Chem (1989) 2.77
Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science (1988) 2.11
High resolution R- and G-banding on the same preparation. Hum Genet (1981) 1.94
Endothelin: a novel peptide in the posterior pituitary system. Science (1990) 1.51
A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity. J Biol Chem (1989) 1.49
cDNA cloning and chromosomal assignment of the gene encoding endothelin 3. J Biol Chem (1989) 1.25
Two different forms of endothelin receptors in rat lung. FEBS Lett (1989) 1.08
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol (2001) 10.32
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84
Comprehensive study on iterative algorithms of multiple sequence alignment. Comput Appl Biosci (1995) 8.39
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature (1991) 7.11
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature (1979) 6.56
Cell-free translation reconstituted with purified components. Nat Biotechnol (2001) 6.55
Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc (1974) 5.53
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro. J Cell Biol (1982) 5.52
Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med (1993) 5.32
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem (1977) 5.16
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron (2001) 5.09
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med (1993) 4.91
Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol (2001) 4.88
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science (1999) 4.69
A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell (1994) 4.35
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. FEBS Lett (1988) 3.96
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell (1994) 3.95
An endothelial receptor for oxidized low-density lipoprotein. Nature (1997) 3.76
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell (1994) 3.66
Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol (1986) 3.66
Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature (1990) 3.23
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci U S A (1986) 3.19
Fos expression in orexin neurons varies with behavioral state. J Neurosci (2001) 3.08
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol (1998) 3.01
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci U S A (1988) 2.99
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development (1998) 2.92
DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell (2001) 2.90
To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci (2001) 2.84
ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell (1994) 2.75
Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation (1995) 2.70
Expression of bacterial chloramphenicol acetyltransferase gene in tobacco plants mediated by TMV-RNA. EMBO J (1987) 2.61
Distribution of orexin neurons in the adult rat brain. Brain Res (1999) 2.60
Three-dimensional structure of ribonuclease H from E. coli. Nature (1990) 2.58
Endothelin system: the double-edged sword in health and disease. Annu Rev Pharmacol Toxicol (2001) 2.58
In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus. Nucleic Acids Res (1986) 2.58
Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. BJOG (2014) 2.56
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell (1999) 2.52
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development (1998) 2.49
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A (1999) 2.39
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem (1989) 2.37
Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet (1994) 2.36
In vitro transcription of infectious RNAs from full-length cDNAs of tobacco mosaic virus. Proc Natl Acad Sci U S A (1986) 2.35
Localization of 6S component of a alpha-actinin at Z-band. J Biochem (1967) 2.33
Orexin-A regulates body temperature in coordination with arousal status. Exp Biol Med (Maywood) (2001) 2.25
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J Cell Biol (1989) 2.24
Fracture on removal of the ACE tibial nail. J Bone Joint Surg Br (1997) 2.23
Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. Circulation (1991) 2.23
A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem Biophys Res Commun (1990) 2.21
Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol (1988) 2.18
Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci (2000) 2.16
Protein Synthesis in Bromegrass (Bromus inermis Leyss) Cultured Cells during the Induction of Frost Tolerance by Abscisic Acid or Low Temperature. Plant Physiol (1987) 2.09
Primary structure of chicken skeletal muscle and fibroblast alpha-actinins deduced from cDNA sequences. Eur J Biochem (1988) 2.08
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem (2001) 2.08
Endothelin, a novel vasoconstrictor peptide, as potent bronchoconstrictor. Eur J Pharmacol (1988) 2.06
Molecular characterization of endothelin receptors. Trends Pharmacol Sci (1992) 2.04
Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas. Br J Surg (2003) 2.04
Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest (1998) 2.04
Molecular biology and biochemistry of the endothelins. Trends Pharmacol Sci (1989) 2.02
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A (2001) 2.01
Myocardial infarction due to coronary thromboarteritis, following acute febrile mucocutaneous lymph node syndrome (MLNS) in an infant. Pediatrics (1974) 2.00
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. EMBO J (1992) 1.98
Identification and characterization of a host protein required for efficient template selection in viral RNA replication. Proc Natl Acad Sci U S A (2000) 1.98
Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung. Cancer Res (1990) 1.97
MASCOT: multiple alignment system for protein sequences based on three-way dynamic programming. Comput Appl Biosci (1993) 1.97
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell (1995) 1.96
Causes of maternal mortality in Japan. JAMA (2000) 1.92
A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. J Biol Chem (1989) 1.92
Formation of brome mosaic virus RNA-dependent RNA polymerase in yeast requires coexpression of viral proteins and viral RNA. Proc Natl Acad Sci U S A (1995) 1.90
Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension (1998) 1.88
Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun (1989) 1.88
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation (1999) 1.88
Synthesis, structural characterization and antimicrobial activities of 4- and 6-coordinate nickel(II) complexes with three thiosemicarbazones and semicarbazone ligands. J Inorg Biochem (2001) 1.87
Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. Circulation (1991) 1.86
Endothelin, a novel endothelium-derived peptide. Pharmacological activities, regulation and possible roles in cardiovascular control. Biochem Pharmacol (1989) 1.86
Recovery from "hepatorenal syndrome" after orthotopic liver transplantation. N Engl J Med (1973) 1.85
Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide? Am J Physiol (1989) 1.85
Microbial flora in the deepest sea mud of the Mariana Trench. FEMS Microbiol Lett (1997) 1.84
Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci U S A (1998) 1.84
Orexin (hypocretin) neurons contain dynorphin. J Neurosci (2001) 1.84
Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol (1999) 1.83
Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci U S A (1996) 1.82