Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 3055481)

Published in Neuropsychopharmacology on February 24, 2010

Authors

Maite Solas1, Bárbara Aisa, María C Mugueta, Joaquín Del Río, Rosa M Tordera, María J Ramírez

Author Affiliations

1: Department of Pharmacology, School of Medicine, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.

Articles citing this

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov (2012) 2.44

Childhood trauma and PTSD symptoms increase the risk of cognitive impairment in a sample of former indentured child laborers in old age. PLoS One (2013) 0.92

Infant maternal separation impairs adult cognitive performance in BALB/cJ mice. Psychopharmacology (Berl) (2011) 0.89

Early life manipulations alter learning and memory in rats. Neurosci Biobehav Rev (2012) 0.88

Aging and stress: past hypotheses, present approaches and perspectives. Aging Dis (2011) 0.87

Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers. Br J Pharmacol (2012) 0.86

Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase. CNS Neurol Disord Drug Targets (2012) 0.85

Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation. Front Endocrinol (Lausanne) (2013) 0.83

Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats. Dis Model Mech (2012) 0.80

Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus. Front Mol Neurosci (2015) 0.80

Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression. Dev Psychopathol (2015) 0.79

Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. PLoS One (2014) 0.78

Why do we need to use animal models to study cognition and aging? Neuropsychopharmacology (2010) 0.78

Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats. PLoS One (2016) 0.77

Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia. Front Behav Neurosci (2015) 0.76

Making Sense of Blood-Based Proteomics and Metabolomics in Psychiatric Research. Int J Neuropsychopharmacol (2015) 0.76

Early-life stress impairs recognition memory and perturbs the functional maturation of prefrontal-hippocampal-perirhinal networks. Sci Rep (2017) 0.75

Educational attainment and mid-life stress as risk factors for dementia in late life. Brain (2010) 0.75

Stress and Corticosteroids Modulate Muscarinic Long Term Potentiation (mLTP) in the Hippocampus. Front Cell Neurosci (2017) 0.75

Articles cited by this

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76

A neurotrophic model for stress-related mood disorders. Biol Psychiatry (2006) 8.97

Depression: a new animal model sensitive to antidepressant treatments. Nature (1977) 8.76

Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry (1999) 7.84

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry (2001) 7.80

Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci (2001) 7.25

Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci (1998) 4.76

Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry (2006) 4.74

New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci (2006) 4.62

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci (2000) 4.55

The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev (1986) 4.21

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis (2005) 3.78

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem (1998) 3.77

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science (1989) 3.47

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 3.11

Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. Nat Neurosci (2008) 3.03

Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus (2006) 3.02

Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period. Brain Res (1986) 2.73

Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging (2002) 2.70

Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A (2009) 2.50

Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci (2006) 2.45

Long-term behavioral and neuroendocrine adaptations to adverse early experience. Prog Brain Res (2000) 2.45

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature (1997) 2.44

Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J (2007) 2.25

Activation of p42 mitogen-activated protein kinase in hippocampal long term potentiation. J Biol Chem (1996) 2.24

Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest (1997) 2.21

Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Am J Psychiatry (2006) 2.05

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett (1994) 1.99

Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms. Genome Res (2007) 1.96

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem (2007) 1.95

Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications. Science (1985) 1.91

Proneness to psychological distress and risk of Alzheimer disease in a biracial community. Neurology (2005) 1.70

Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol (2006) 1.69

Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology (2007) 1.64

Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. J Clin Invest (1997) 1.63

Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol Psychiatry (2004) 1.59

Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model. FASEB J (2006) 1.59

Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Exp Neurol (2007) 1.58

Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB J (2004) 1.56

The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol Psychiatry (1999) 1.52

Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol Psychiatry (2002) 1.50

Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain Res (2002) 1.47

Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Horm Res (2001) 1.46

Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress. Proc Natl Acad Sci U S A (2000) 1.44

Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. Physiol Behav (1999) 1.44

Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing? Rev Neurosci (2000) 1.43

Lifelong corticosterone level determines age-related decline in neurogenesis and memory. Neurobiol Aging (2005) 1.39

Mitogen-activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a review. Genes Brain Behav (2006) 1.35

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci (1996) 1.25

Aging, stress and the hippocampus. Ageing Res Rev (2005) 1.24

Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol Aging (1997) 1.22

The amyloidogenic potential and behavioral correlates of stress. Mol Psychiatry (2007) 1.22

Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque. J Neuropathol Exp Neurol (2005) 1.18

The adrenocortical stress-response in the aged male rat: impairment of recovery from stress. Exp Gerontol (1983) 1.14

Glucocorticoid toxicity in the hippocampus: temporal aspects of neuronal vulnerability. Brain Res (1985) 1.08

Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats. Eur J Neurosci (2000) 1.07

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Brain Res Mol Brain Res (1999) 1.06

Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease. Biol Psychiatry (2005) 1.01

Regulation of brain-derived neurotrophic factor-mediated transcription of the immediate early gene Arc by intracellular calcium and calmodulin. J Neurosci Res (2009) 0.98

Effects of age and gender on pituitary-adrenocortical responsiveness in humans. Eur J Endocrinol (1995) 0.96

Cellular mechanisms in selected states of insulin resistance: human obesity, glucocorticoid excess, and chronic renal failure. Diabetes Metab Rev (1985) 0.96

Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology (1994) 0.95

Glucocorticoids may initiate Alzheimer's disease: a potential therapeutic role for mifepristone (RU-486). Med Hypotheses (2006) 0.88

Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats. Psychopharmacology (Berl) (2003) 0.78

Articles by these authors

Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am J Hum Genet (2013) 2.15

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J (2007) 1.65

Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology (2007) 1.64

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease. J Alzheimers Dis (2009) 1.29

Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: implications for spatial memory. Hippocampus (2009) 1.22

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model. Biochem Biophys Res Commun (2008) 1.15

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Neurobiol Dis (2008) 1.13

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology (2010) 1.12

Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia. Hum Mol Genet (2002) 1.10

Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus. Neuropharmacology (2002) 1.09

Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Biochem Biophys Res Commun (2006) 1.01

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiol Aging (2005) 0.99

Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice. Behav Neurosci (2007) 0.99

Sustained stress-induced changes in mice as a model for chronic depression. Psychopharmacology (Berl) (2010) 0.97

Clusters of transcription-coupled repair in the human genome. Proc Natl Acad Sci U S A (2002) 0.97

Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment. Neuropharmacology (2005) 0.96

Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. Biol Psychiatry (2009) 0.95

Neurochemical basis for symptomatic treatment of Alzheimer's disease. Neuropharmacology (2010) 0.93

Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: involvement of the HPA axis. Psychoneuroendocrinology (2009) 0.91

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β. J Alzheimers Dis (2011) 0.91

Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1. J Neurochem (2010) 0.88

Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus. Brain Res Mol Brain Res (2004) 0.87

HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease. J Alzheimers Dis (2010) 0.86

2-Oxopiperazine-based gamma-turn conformationally constrained peptides: synthesis of CCK-4 analogues. J Org Chem (2002) 0.85

Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus (2010) 0.84

Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease. Neurobiol Dis (2006) 0.84

Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on BDNF mRNA expression in rat frontal cortex and hippocampus. Neurosci Lett (2006) 0.84

Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Eur J Neurosci (2006) 0.84

Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. J Med Chem (2002) 0.83

Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. Eur J Pharmacol (2002) 0.83

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res (2011) 0.83

Serotonin 5-HT receptor blockade enhances Ca(2+)/calmodulin-dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus: implications for memory formation. J Neurochem (2005) 0.82

Effects of early maternal separation on biobehavioral and neuropathological markers of Alzheimer's disease in adult male rats. Curr Alzheimer Res (2013) 0.81

Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats. Dis Model Mech (2012) 0.80

Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects. Int J Neuropsychopharmacol (2009) 0.80

Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. Biochim Biophys Acta (2013) 0.80

GABA(A) receptor antagonists enhance cortical acetylcholine release induced by 5-HT(3) receptor blockade in freely moving rats. Brain Res (2002) 0.80

Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res (2011) 0.79

Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status. Drugs (2014) 0.79

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice. Int J Neuropsychopharmacol (2013) 0.78

Neuroprotective effects of serotonin 5-HT 1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF. Brain Res (2008) 0.78

New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett (2006) 0.78

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships. Bioorg Med Chem Lett (2005) 0.78

Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. J Chem Neuroanat (2011) 0.78

Impact of prior rituximab on outcomes of autologous stem-cell transplantation in patients with relapsed or refractory aggressive B-cell lymphoma: a multicentre retrospective Spanish group of lymphoma/autologous bone marrow transplant study. Br J Haematol (2013) 0.78

Role of hippocampal CaMKII in serotonin 5-HT(1A) receptor-mediated learning deficit in rats. Neuropsychopharmacology (2004) 0.77

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett (2006) 0.77

Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry (2003) 0.77

Over-expression of muscle glycogen synthase in human diabetic nephropathy. Histochem Cell Biol (2014) 0.76

Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology (2012) 0.76

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. J Neurochem (2003) 0.76

Facilitation of cholinergic transmission by combined treatment of ondansetron with flumazenil after cortical cholinergic deafferentation. Neuropharmacology (2004) 0.76

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292. Bioorg Med Chem Lett (2002) 0.75

5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectivity toward CCK2 receptors. J Med Chem (2004) 0.75

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage. J Med Chem (2011) 0.75

Relationship between chromosome fragility, aneuploidy and severity of the haematological disease in Fanconi anaemia. Mutat Res (2002) 0.75

Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. Synapse (2009) 0.75

Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem (2011) 0.75

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. Bioorg Med Chem Lett (2003) 0.75

Involvement of the vascular wall in regenerative processes after CA1 ischemic neuronal death. Int J Dev Neurosci (2008) 0.75

Pharmacokinetic and milk penetration of a difloxacin long-acting poloxamer gel formulation with carboxy-methylcellulose in lactating goats. Vet J (2010) 0.75

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics. J Med Chem (2005) 0.75

Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. Bioorg Med Chem (2004) 0.75