| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
|
Nat Genet
|
2008
|
8.63
|
|
2
|
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
Nat Genet
|
2009
|
8.11
|
|
3
|
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
Nat Genet
|
2009
|
5.29
|
|
4
|
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
|
Nat Genet
|
2012
|
4.84
|
|
5
|
Genome-wide association study of hematological and biochemical traits in a Japanese population.
|
Nat Genet
|
2010
|
4.36
|
|
6
|
Seven new loci associated with age-related macular degeneration.
|
Nat Genet
|
2013
|
3.81
|
|
7
|
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
Nat Genet
|
2012
|
3.71
|
|
8
|
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.
|
J Clin Oncol
|
2010
|
3.21
|
|
9
|
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
|
Lancet
|
2013
|
3.21
|
|
10
|
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
Nat Genet
|
2011
|
3.19
|
|
11
|
Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.
|
Am J Hum Genet
|
2008
|
3.12
|
|
12
|
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
Gastroenterology
|
2009
|
3.04
|
|
13
|
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
|
Nat Genet
|
2012
|
3.04
|
|
14
|
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
|
J Clin Oncol
|
2010
|
3.02
|
|
15
|
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
Nat Genet
|
2010
|
2.92
|
|
16
|
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
Nat Genet
|
2010
|
2.81
|
|
17
|
Meta-analysis identifies common variants associated with body mass index in east Asians.
|
Nat Genet
|
2012
|
2.70
|
|
18
|
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
|
Nat Genet
|
2010
|
2.34
|
|
19
|
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
|
Nat Genet
|
2012
|
2.31
|
|
20
|
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
Nat Genet
|
2011
|
2.27
|
|
21
|
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
Nat Genet
|
2009
|
2.26
|
|
22
|
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|
Nat Genet
|
2011
|
2.10
|
|
23
|
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
|
Nat Genet
|
2011
|
2.09
|
|
24
|
Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing.
|
Nat Genet
|
2010
|
2.08
|
|
25
|
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
|
Nat Genet
|
2012
|
2.05
|
|
26
|
Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility.
|
Cancer Sci
|
2010
|
2.03
|
|
27
|
High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study.
|
Arterioscler Thromb Vasc Biol
|
2008
|
1.98
|
|
28
|
Ten-year prognosis of stroke and risk factors for death in a Japanese community: the Hisayama study.
|
Stroke
|
2003
|
1.97
|
|
29
|
Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study.
|
Kidney Int
|
2005
|
1.96
|
|
30
|
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
Hum Mol Genet
|
2011
|
1.96
|
|
31
|
Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.
|
Cancer Sci
|
2008
|
1.95
|
|
32
|
A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.
|
Hum Mol Genet
|
2011
|
1.91
|
|
33
|
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
|
Nat Genet
|
2012
|
1.90
|
|
34
|
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
|
Nat Genet
|
2010
|
1.90
|
|
35
|
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
|
Nat Genet
|
2013
|
1.90
|
|
36
|
A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.
|
Nat Genet
|
2011
|
1.86
|
|
37
|
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.
|
Hum Mol Genet
|
2010
|
1.83
|
|
38
|
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
|
Gastroenterology
|
2011
|
1.83
|
|
39
|
A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.
|
Hum Genet
|
2010
|
1.75
|
|
40
|
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
|
PLoS Genet
|
2011
|
1.75
|
|
41
|
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population.
|
Nat Genet
|
2008
|
1.73
|
|
42
|
Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: the Hisayama study.
|
Stroke
|
2007
|
1.67
|
|
43
|
Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection: a population-based cohort study.
|
Gastroenterology
|
2008
|
1.65
|
|
44
|
Multiple loci are associated with white blood cell phenotypes.
|
PLoS Genet
|
2011
|
1.65
|
|
45
|
Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema.
|
Pharmacogenet Genomics
|
2013
|
1.65
|
|
46
|
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.
|
Nat Genet
|
2012
|
1.59
|
|
47
|
A genome-wide association study identifies three new risk loci for Kawasaki disease.
|
Nat Genet
|
2012
|
1.58
|
|
48
|
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
|
Nat Genet
|
2012
|
1.58
|
|
49
|
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese.
|
Nat Genet
|
2010
|
1.57
|
|
50
|
Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.
|
J Hum Genet
|
2007
|
1.55
|
|
51
|
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
|
Nat Genet
|
2012
|
1.51
|
|
52
|
Relationship between drinking and periodontitis: the Hisayama Study.
|
J Periodontol
|
2005
|
1.51
|
|
53
|
Genome-wide association study of pancreatic cancer in Japanese population.
|
PLoS One
|
2010
|
1.50
|
|
54
|
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
|
Clin Cancer Res
|
2012
|
1.50
|
|
55
|
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
|
Hum Mol Genet
|
2010
|
1.49
|
|
56
|
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
|
PLoS Genet
|
2011
|
1.45
|
|
57
|
A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study.
|
Int J Cancer
|
2006
|
1.44
|
|
58
|
The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.
|
Arthritis Rheum
|
2010
|
1.43
|
|
59
|
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
|
Nat Genet
|
2011
|
1.43
|
|
60
|
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
|
Nat Genet
|
2010
|
1.42
|
|
61
|
Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients.
|
Breast Cancer Res Treat
|
2011
|
1.39
|
|
62
|
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
|
Nat Genet
|
2012
|
1.37
|
|
63
|
Multiplex PCR-based real-time invader assay (mPCR-RETINA): a novel SNP-based method for detecting allelic asymmetries within copy number variation regions.
|
Hum Mutat
|
2008
|
1.36
|
|
64
|
Liver enzymes as a predictor for incident diabetes in a Japanese population: the Hisayama study.
|
Obesity (Silver Spring)
|
2007
|
1.34
|
|
65
|
Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
|
Pharmacogenet Genomics
|
2012
|
1.34
|
|
66
|
IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.
|
J Hepatol
|
2011
|
1.32
|
|
67
|
Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.
|
J Hepatol
|
2010
|
1.31
|
|
68
|
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
|
Nat Genet
|
2011
|
1.31
|
|
69
|
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
|
Hum Mol Genet
|
2010
|
1.30
|
|
70
|
Dialysis-related hypotension as a cause of progressive frontal lobe atrophy in chronic hemodialysis patients: a 3-year prospective study.
|
Nephron Clin Pract
|
2004
|
1.30
|
|
71
|
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
|
Am J Hum Genet
|
2012
|
1.29
|
|
72
|
The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study.
|
Am J Epidemiol
|
2006
|
1.29
|
|
73
|
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
Hum Mol Genet
|
2013
|
1.28
|
|
74
|
New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
|
PLoS One
|
2010
|
1.27
|
|
75
|
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
Clin Cancer Res
|
2011
|
1.26
|
|
76
|
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
|
Hum Mol Genet
|
2010
|
1.25
|
|
77
|
Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: the Hisayama Study.
|
Diabetes Care
|
2005
|
1.25
|
|
78
|
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.
|
Hum Mol Genet
|
2012
|
1.24
|
|
79
|
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
|
Hum Mol Genet
|
2012
|
1.23
|
|
80
|
Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study.
|
Am J Kidney Dis
|
2006
|
1.22
|
|
81
|
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
|
Clin Cancer Res
|
2012
|
1.22
|
|
82
|
Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
|
J Epidemiol
|
2011
|
1.22
|
|
83
|
The prevalence of pseudoexfoliation syndrome in a Japanese population: the Hisayama study.
|
J Glaucoma
|
2005
|
1.22
|
|
84
|
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
|
Hum Mol Genet
|
2010
|
1.21
|
|
85
|
CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection.
|
Clin Chem
|
2009
|
1.19
|
|
86
|
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
|
Gastroenterology
|
2012
|
1.19
|
|
87
|
A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population.
|
Hum Mol Genet
|
2010
|
1.17
|
|
88
|
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.
|
PLoS Genet
|
2012
|
1.17
|
|
89
|
Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence: the Hisayama Study.
|
Am J Epidemiol
|
2008
|
1.17
|
|
90
|
Common variation in GPC5 is associated with acquired nephrotic syndrome.
|
Nat Genet
|
2011
|
1.17
|
|
91
|
IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.
|
J Gen Virol
|
2011
|
1.16
|
|
92
|
Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.
|
PLoS One
|
2012
|
1.15
|
|
93
|
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.
|
Cancer Sci
|
2008
|
1.14
|
|
94
|
Controlled, prospective trial of steroid treatment in IgA nephropathy: a limitation of low-dose prednisolone therapy.
|
Am J Kidney Dis
|
2003
|
1.14
|
|
95
|
Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis.
|
J Hum Genet
|
2012
|
1.14
|
|
96
|
Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
|
Hum Mol Genet
|
2010
|
1.13
|
|
97
|
Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.
|
Breast Cancer Res
|
2012
|
1.13
|
|
98
|
Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.
|
Cancer Discov
|
2013
|
1.12
|
|
99
|
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
|
Circulation
|
2014
|
1.11
|
|
100
|
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.
|
J Hum Genet
|
2009
|
1.11
|
|
101
|
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
|
Nat Genet
|
2013
|
1.11
|
|
102
|
Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction.
|
Hum Mol Genet
|
2007
|
1.11
|
|
103
|
Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis.
|
Inflamm Bowel Dis
|
2011
|
1.10
|
|
104
|
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.
|
PLoS Genet
|
2012
|
1.09
|
|
105
|
Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population.
|
J Hum Genet
|
2009
|
1.08
|
|
106
|
Evaluating genetic risk for prostate cancer among Japanese and Latinos.
|
Cancer Epidemiol Biomarkers Prev
|
2012
|
1.08
|
|
107
|
C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: the Hisayama Study.
|
Stroke
|
2005
|
1.07
|
|
108
|
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
|
Circ Res
|
2017
|
1.06
|
|
109
|
Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies.
|
Genet Epidemiol
|
2011
|
1.06
|
|
110
|
Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study.
|
Nephrol Dial Transplant
|
2010
|
1.05
|
|
111
|
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.
|
Hum Mol Genet
|
2012
|
1.05
|
|
112
|
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.
|
PLoS One
|
2013
|
1.04
|
|
113
|
Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.
|
Int J Cancer
|
2014
|
1.03
|
|
114
|
Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays.
|
Pharmacogenet Genomics
|
2010
|
1.03
|
|
115
|
TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
|
Mol Endocrinol
|
2013
|
1.02
|
|
116
|
LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama study.
|
Stroke
|
2008
|
1.00
|
|
117
|
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
|
Cancer Sci
|
2013
|
1.00
|
|
118
|
Association study of 71 European Crohn's disease susceptibility loci in a Japanese population.
|
Inflamm Bowel Dis
|
2013
|
0.99
|
|
119
|
A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression.
|
Hum Mol Genet
|
2010
|
0.99
|
|
120
|
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
|
J Clin Invest
|
2013
|
0.98
|
|
121
|
Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.
|
Clin Cancer Res
|
2011
|
0.98
|
|
122
|
Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study.
|
Graefes Arch Clin Exp Ophthalmol
|
2003
|
0.97
|
|
123
|
Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: the Hisayama study.
|
Diabetes Care
|
2005
|
0.97
|
|
124
|
A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis.
|
J Hum Genet
|
2012
|
0.97
|
|
125
|
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
|
Hum Mol Genet
|
2013
|
0.97
|
|
126
|
Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study.
|
Stroke
|
2009
|
0.96
|
|
127
|
A practical method to detect SNVs and indels from whole genome and exome sequencing data.
|
Sci Rep
|
2013
|
0.96
|
|
128
|
Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.
|
J Pharmacol Exp Ther
|
2010
|
0.96
|
|
129
|
Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese.
|
PLoS One
|
2012
|
0.96
|
|
130
|
QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study.
|
Hypertens Res
|
2010
|
0.96
|
|
131
|
Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population.
|
PLoS One
|
2012
|
0.95
|
|
132
|
Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1.
|
Arthritis Rheum
|
2009
|
0.95
|
|
133
|
IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
|
Hum Mol Genet
|
2012
|
0.95
|
|
134
|
Alcohol intake and future incidence of hypertension in a general Japanese population: the Hisayama study.
|
Alcohol Clin Exp Res
|
2002
|
0.95
|
|
135
|
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
|
Clin Infect Dis
|
2011
|
0.95
|
|
136
|
Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics.
|
Mol Endocrinol
|
2014
|
0.94
|
|
137
|
Lack of association between variations of PDE4D and ischemic stroke in the Japanese population.
|
Stroke
|
2009
|
0.94
|
|
138
|
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.
|
J Hum Genet
|
2012
|
0.94
|
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139
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