Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
|
Science
|
2007
|
37.88
|
2
|
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
Nat Genet
|
2008
|
35.06
|
3
|
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
Science
|
2007
|
32.97
|
4
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
5
|
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
|
Nat Genet
|
2007
|
12.62
|
6
|
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.
|
Nature
|
2010
|
12.27
|
7
|
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
|
Diabetes
|
2003
|
8.19
|
8
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
9
|
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
|
Mol Cell
|
2007
|
5.29
|
10
|
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
|
PLoS Med
|
2011
|
3.94
|
11
|
Teenage pregnancy and adverse birth outcomes: a large population based retrospective cohort study.
|
Int J Epidemiol
|
2007
|
3.88
|
12
|
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
|
Diabetes
|
2007
|
3.84
|
13
|
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
|
Diabetes
|
2006
|
3.79
|
14
|
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
|
PLoS Med
|
2006
|
3.75
|
15
|
No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
|
Diabetes
|
2006
|
3.58
|
16
|
Common variants in WFS1 confer risk of type 2 diabetes.
|
Nat Genet
|
2007
|
3.58
|
17
|
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
|
Diabetes
|
2006
|
3.51
|
18
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
19
|
Selective serotonin reuptake inhibitors and adverse pregnancy outcomes.
|
Am J Obstet Gynecol
|
2006
|
3.09
|
20
|
Chk1 is required for spindle checkpoint function.
|
Dev Cell
|
2007
|
2.90
|
21
|
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
Nat Genet
|
2011
|
2.73
|
22
|
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
|
Diabetes
|
2007
|
2.73
|
23
|
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.
|
Nat Genet
|
2005
|
2.66
|
24
|
A globally optimal k-anonymity method for the de-identification of health data.
|
J Am Med Inform Assoc
|
2009
|
2.66
|
25
|
Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome.
|
Nat Genet
|
2002
|
2.50
|
26
|
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
|
Diabetes
|
2010
|
2.44
|
27
|
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|
Diabetes
|
2011
|
2.21
|
28
|
An international trial of antioxidants in the prevention of preeclampsia (INTAPP).
|
Am J Obstet Gynecol
|
2010
|
1.90
|
29
|
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
Nat Genet
|
2013
|
1.72
|
30
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
31
|
The fetal alert network: an innovative program of access to care, surveillance, and education for birth defects in Ontario.
|
J Obstet Gynaecol Can
|
2006
|
1.69
|
32
|
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
Diabetes
|
2008
|
1.64
|
33
|
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects.
|
Eur Heart J
|
2007
|
1.63
|
34
|
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
|
Hum Mol Genet
|
2009
|
1.61
|
35
|
Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells.
|
Mol Genet Metab
|
2007
|
1.60
|
36
|
Risk of birth defects increased in pregnancies conceived by assisted human reproduction.
|
Fertil Steril
|
2008
|
1.58
|
37
|
Gestational age-specific severe maternal morbidity associated with labor induction.
|
Am J Obstet Gynecol
|
2013
|
1.57
|
38
|
Maternal exposure to moderate ambient carbon monoxide is associated with decreased risk of preeclampsia.
|
Am J Obstet Gynecol
|
2012
|
1.56
|
39
|
The association between fetal sex and preterm birth in twin pregnancies.
|
Obstet Gynecol
|
2004
|
1.51
|
40
|
The natural history of pelvic vein thrombosis on magnetic resonance venography after vaginal delivery.
|
Am J Obstet Gynecol
|
2012
|
1.49
|
41
|
Incidence, risk factors, and associated complications of eclampsia.
|
Obstet Gynecol
|
2011
|
1.49
|
42
|
Insulin resistance, insulin response, and obesity as indicators of metabolic risk.
|
J Clin Endocrinol Metab
|
2007
|
1.49
|
43
|
Epidemiology of preterm birth and neonatal outcome.
|
Semin Fetal Neonatal Med
|
2004
|
1.49
|
44
|
Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations.
|
Hum Mol Genet
|
2007
|
1.40
|
45
|
DNA damage induces Chk1-dependent centrosome amplification.
|
EMBO Rep
|
2007
|
1.39
|
46
|
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.
|
Diabetes
|
2002
|
1.37
|
47
|
Key role for ceramides in mediating insulin resistance in human muscle cells.
|
J Biol Chem
|
2007
|
1.35
|
48
|
Comparison of maternal mortality and morbidity between trial of labor and elective cesarean section among women with previous cesarean delivery.
|
Am J Obstet Gynecol
|
2004
|
1.33
|
49
|
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
|
Diabetes
|
2008
|
1.33
|
50
|
Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
|
Am J Hum Genet
|
2001
|
1.32
|
51
|
Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C.
|
Am J Med Genet A
|
2008
|
1.30
|
52
|
Environmental hazards: evidence for effects on child health.
|
J Toxicol Environ Health B Crit Rev
|
2007
|
1.27
|
53
|
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
|
Diabetes
|
2004
|
1.25
|
54
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
55
|
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
|
Am J Hum Genet
|
2003
|
1.24
|
56
|
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.
|
J Hum Genet
|
2005
|
1.21
|
57
|
Determinants of caesarean delivery among women hospitalized for childbirth in a remote population in China.
|
J Obstet Gynaecol Can
|
2003
|
1.19
|
58
|
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
|
Diabetes
|
2005
|
1.18
|
59
|
Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT.
|
PLoS One
|
2013
|
1.16
|
60
|
Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK.
|
BMC Public Health
|
2009
|
1.16
|
61
|
Prenatal social support, postnatal social support, and postpartum depression.
|
Ann Epidemiol
|
2009
|
1.11
|
62
|
Exploring informed choice in the context of prenatal testing: findings from a qualitative study.
|
Health Expect
|
2008
|
1.11
|
63
|
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
|
Anal Chem
|
2008
|
1.10
|
64
|
Fetal gender and postpartum depression in a cohort of Chinese women.
|
Soc Sci Med
|
2007
|
1.08
|
65
|
Neonatal death and morbidity in vertex-nonvertex second twins according to mode of delivery and birth weight.
|
Am J Obstet Gynecol
|
2005
|
1.08
|
66
|
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
|
Diabetes
|
2004
|
1.07
|
67
|
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
|
Diabetes
|
2013
|
1.06
|
68
|
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.
|
Diabetes
|
2006
|
1.04
|
69
|
Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
|
Diabetes
|
2003
|
1.03
|
70
|
Cohort profile: the maternal-infant research on environmental chemicals research platform.
|
Paediatr Perinat Epidemiol
|
2013
|
1.03
|
71
|
Progesterone for the prevention of preterm birth among women at increased risk: a systematic review and meta-analysis of randomized controlled trials.
|
Am J Obstet Gynecol
|
2006
|
1.03
|
72
|
Participation of pregnant women in clinical trials: will they participate and why?
|
Am J Perinatol
|
2003
|
1.02
|
73
|
The influence of experiential knowledge on prenatal screening and testing decisions.
|
Genet Test
|
2008
|
1.02
|
74
|
Risk factors of obesity in preschool children in an urban area in China.
|
Eur J Pediatr
|
2011
|
1.01
|
75
|
Treating and drinking well water in the presence of health risks from arsenic contamination: results from a U.S. hot spot.
|
Risk Anal
|
2005
|
1.01
|
76
|
Neonatal mortality in second twin according to cause of death, gestational age, and mode of delivery.
|
Am J Obstet Gynecol
|
2004
|
0.98
|
77
|
Occurrence and clinical predictors of operative delivery for the vertex second twin after normal vaginal delivery of the first twin.
|
Am J Obstet Gynecol
|
2005
|
0.98
|
78
|
Missing paternal demographics: A novel indicator for identifying high risk population of adverse pregnancy outcomes.
|
BMC Pregnancy Childbirth
|
2004
|
0.97
|
79
|
Familial myopathy: new insights into the T14709C mitochondrial tRNA mutation.
|
Ann Neurol
|
2004
|
0.96
|
80
|
Variation in the calpain-10 gene affects blood glucose levels in the British population.
|
Diabetes
|
2002
|
0.96
|
81
|
The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
|
Diabetes
|
2006
|
0.96
|
82
|
Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes.
|
CMAJ
|
2008
|
0.96
|
83
|
A method for managing re-identification risk from small geographic areas in Canada.
|
BMC Med Inform Decis Mak
|
2010
|
0.95
|
84
|
Neonatal morbidity in second twin according to gestational age at birth and mode of delivery.
|
Am J Obstet Gynecol
|
2004
|
0.95
|
85
|
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
|
Hepatology
|
2012
|
0.94
|
86
|
Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
|
Diabetes
|
2004
|
0.94
|
87
|
Predictors of pediatric emergency patients discharged against medical advice.
|
Clin Pediatr (Phila)
|
2008
|
0.94
|
88
|
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
|
Diabetes
|
2003
|
0.93
|
89
|
Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant.
|
Prog Brain Res
|
2008
|
0.93
|
90
|
The risk of adverse pregnancy outcomes is increased in preeclamptic women who smoke compared with nonpreeclamptic women who do not smoke.
|
Am J Obstet Gynecol
|
2010
|
0.92
|
91
|
Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance.
|
J Clin Endocrinol Metab
|
2010
|
0.92
|
92
|
Large pre- and postexercise rapid-acting insulin reductions preserve glycemia and prevent early- but not late-onset hypoglycemia in patients with type 1 diabetes.
|
Diabetes Care
|
2013
|
0.92
|
93
|
Hypertensive disorders of pregnancy and long-term risk of hypertension: what do Ontario prenatal care providers know, and what do they communicate?
|
J Obstet Gynaecol Can
|
2007
|
0.91
|
94
|
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
|
Diabetes
|
2003
|
0.91
|
95
|
Imaging response to chemotherapy with RMP-7 and carboplatin in malignant glioma: size matters but speed does not.
|
J Neurooncol
|
2002
|
0.90
|
96
|
Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants.
|
Int J Hyg Environ Health
|
2012
|
0.90
|
97
|
Survival of a pathogenic Leptospira serovar in response to combined in vitro pH and temperature stresses.
|
Vet Microbiol
|
2011
|
0.90
|
98
|
Vero cytotoxin-producing Escherichia coli O157 gastroenteritis in farm visitors, North Wales.
|
Emerg Infect Dis
|
2003
|
0.90
|
99
|
Assessing the value of customized birth weight percentiles.
|
Am J Epidemiol
|
2010
|
0.90
|
100
|
Influence of hyperinsulinemia and insulin resistance on in vivo β-cell function: their role in human β-cell dysfunction.
|
Diabetes
|
2011
|
0.90
|
101
|
Prenatal family support, postnatal family support and postpartum depression.
|
Aust N Z J Obstet Gynaecol
|
2010
|
0.90
|
102
|
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
|
J Clin Invest
|
2015
|
0.90
|
103
|
Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study.
|
BMC Public Health
|
2010
|
0.89
|
104
|
Motor mechanisms of vertical fusion in individuals with superior oblique paresis.
|
J AAPOS
|
2002
|
0.89
|
105
|
Cesarean section and postpartum depression in a cohort of Chinese women with a high cesarean delivery rate.
|
J Womens Health (Larchmt)
|
2011
|
0.89
|
106
|
Reference values of semen parameters for healthy Chinese men.
|
Urol Int
|
2008
|
0.89
|
107
|
Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes.
|
Growth Horm IGF Res
|
2008
|
0.89
|
108
|
The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
|
BMC Med Genet
|
2006
|
0.89
|
109
|
Risk of subsequent thromboembolism for patients with pre-eclampsia.
|
BMJ
|
2003
|
0.88
|
110
|
Cesarean delivery for first pregnancy and neonatal morbidity and mortality in second pregnancy.
|
Eur J Obstet Gynecol Reprod Biol
|
2011
|
0.87
|
111
|
Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome.
|
Diabetes
|
2002
|
0.87
|
112
|
Occurrence and predictors of cesarean delivery for the second twin after vaginal delivery of the first twin.
|
Obstet Gynecol
|
2004
|
0.87
|
113
|
Significance of IGFBP-4 in the development of fetal growth restriction.
|
J Clin Endocrinol Metab
|
2012
|
0.86
|
114
|
Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects.
|
Diabetes Care
|
2008
|
0.86
|
115
|
Prevalence, management, and outcomes of preterm prelabour rupture of the membranes of women in Canada.
|
J Obstet Gynaecol Can
|
2005
|
0.86
|
116
|
UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
|
FEBS J
|
2007
|
0.86
|
117
|
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
|
Diabetes
|
2012
|
0.86
|
118
|
Cell transformation by v-Jun deactivates ERK MAP kinase signalling.
|
Oncogene
|
2002
|
0.85
|
119
|
Oncology comparative effectiveness research: a multistakeholder perspective on principles for conduct and reporting.
|
Oncologist
|
2013
|
0.85
|
120
|
Fetal sex, social support, and postpartum depression.
|
Can J Psychiatry
|
2009
|
0.84
|
121
|
Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates.
|
Clin Biochem
|
2011
|
0.84
|
122
|
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
|
Diabetes
|
2007
|
0.84
|
123
|
Parental race, birth weight, gestational age, and fetal growth among twin infants in the United States.
|
Early Hum Dev
|
2004
|
0.84
|
124
|
New-onset hypertension in late pregnancy is associated with lower fetal and infant mortality in preterm twins.
|
Hypertens Pregnancy
|
2006
|
0.84
|
125
|
Risk of fetal exposure to folic acid antagonists.
|
J Obstet Gynaecol Can
|
2004
|
0.84
|
126
|
Increased fall risk is associated with elevated co-contraction about the ankle during static balance challenges in older adults.
|
Eur J Appl Physiol
|
2011
|
0.84
|
127
|
Maternal age, paternal age and new-onset hypertension in late pregnancy.
|
Hypertens Pregnancy
|
2006
|
0.84
|
128
|
Endocrine disorders in mitochondrial disease.
|
Mol Cell Endocrinol
|
2013
|
0.83
|
129
|
Environmental lead level and pregnancy-induced hypertension.
|
Environ Res
|
2005
|
0.83
|
130
|
The Maternal Obesity Management (MOM) Trial Protocol: a lifestyle intervention during pregnancy to minimize downstream obesity.
|
Contemp Clin Trials
|
2013
|
0.83
|
131
|
Early prediction of preterm birth for singleton, twin, and triplet pregnancies.
|
Eur J Obstet Gynecol Reprod Biol
|
2007
|
0.83
|
132
|
Absolute vs relative improvements in congenital diaphragmatic hernia survival: what happened to "hidden mortality".
|
J Pediatr Surg
|
2009
|
0.83
|
133
|
Mitotic index determination by flow cytometry.
|
Subcell Biochem
|
2006
|
0.82
|
134
|
Exploring reasons for variation in urinary catheterisation prevalence in care homes: a qualitative study.
|
Age Ageing
|
2008
|
0.82
|
135
|
Langerhans cell histiocytosis of the optic chiasm.
|
Clin Experiment Ophthalmol
|
2007
|
0.82
|
136
|
Causal connections between water quality and land use in a rural tropical island watershed: rural tropical island watershed analysis.
|
Ecohealth
|
2010
|
0.81
|
137
|
Randomized controlled trial of rectal misoprostol versus oxytocin in third stage management.
|
J Obstet Gynaecol Can
|
2002
|
0.81
|
138
|
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.
|
Diabetologia
|
2014
|
0.81
|
139
|
The effect of maternal Class III obesity on neonatal outcomes: a retrospective matched cohort study.
|
J Matern Fetal Neonatal Med
|
2012
|
0.81
|
140
|
The effect of parental race on fetal and infant mortality in twin gestations.
|
J Natl Med Assoc
|
2004
|
0.81
|
141
|
Neonatal mortality and morbidity rates in term twins with advancing gestational age.
|
Am J Obstet Gynecol
|
2006
|
0.80
|
142
|
Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
|
JOP
|
2006
|
0.80
|
143
|
Relationship between intertwin delivery interval and metabolic acidosis in the second twin.
|
Am J Perinatol
|
2006
|
0.80
|
144
|
Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: results of a pilot biomonitoring study.
|
Sci Total Environ
|
2012
|
0.80
|
145
|
The distribution of intra-twin birth weight discordance and its association with total twin birth weight, gestational age, and neonatal mortality.
|
Eur J Obstet Gynecol Reprod Biol
|
2005
|
0.80
|
146
|
Neural activation during response inhibition differentiates blast from mechanical causes of mild to moderate traumatic brain injury.
|
J Neurotrauma
|
2013
|
0.80
|
147
|
Role of glycogen content in insulin resistance in human muscle cells.
|
J Cell Physiol
|
2007
|
0.80
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148
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