Published in J Biol Chem on February 25, 2010
Endothelium--role in regulation of coagulation and inflammation. Semin Immunopathol (2011) 1.37
NF-κB inducing kinase: a key regulator in the immune system and in cancer. Cytokine Growth Factor Rev (2010) 1.28
NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression. J Biol Chem (2012) 1.24
TRAF molecules in cell signaling and in human diseases. J Mol Signal (2013) 1.22
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev (2011) 1.18
Fine-tuning of dendritic cell biology by the TNF superfamily. Nat Rev Immunol (2012) 1.02
Nuclear β-adrenergic receptors modulate gene expression in adult rat heart. Cell Signal (2010) 1.01
Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus. Am J Cancer Res (2011) 0.98
Charting the NF-κB pathway interactome map. PLoS One (2012) 0.94
Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor. Mol Cell Biol (2011) 0.90
HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia. J Neuroinflammation (2012) 0.89
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest (2013) 0.88
The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways. Cell Cycle (2014) 0.85
Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Am J Physiol Endocrinol Metab (2015) 0.84
Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem (2014) 0.81
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun (2016) 0.81
Lymphotoxin-sensitive microenvironments in homeostasis and inflammation. Front Immunol (2012) 0.80
Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity. Mol Metab (2015) 0.78
NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5' Long Terminal Repeat. J Virol (2016) 0.76
Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT. Mol Immunol (2014) 0.76
Association between genetic variations in tumor necrosis factor receptor genes and survival of patients with T-cell lymphoma. Chin J Cancer (2012) 0.75
Signaling to NF-kappaB. Genes Dev (2004) 19.78
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 12.59
The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol (2004) 10.85
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell (2001) 5.88
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72
Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev (1997) 5.65
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity (2002) 5.38
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (1999) 5.15
Dendritic cells in a mature age. Nat Rev Immunol (2006) 5.03
Immunity, inflammation, and allergy in the gut. Science (2005) 4.82
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol (2002) 4.64
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol (2008) 4.33
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem (2004) 3.35
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci (2002) 3.31
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene (2001) 2.98
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med (1998) 2.80
TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem (2003) 2.69
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem (2001) 2.21
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem (2003) 2.20
Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med (2006) 2.17
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity (2004) 2.17
Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat Rev Immunol (2003) 2.10
RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem (2003) 1.96
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev (2000) 1.96
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci U S A (2005) 1.87
Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. J Biol Chem (2003) 1.87
Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proc Natl Acad Sci U S A (1997) 1.76
Lymphotoxin and LIGHT signaling pathways and target genes. Immunol Rev (2004) 1.67
Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines. J Exp Med (1996) 1.62
Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J Exp Med (2004) 1.58
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J Immunol (2002) 1.50
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. J Biol Chem (2003) 1.29
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. J Biol Chem (2004) 1.24
Regulation of TRAF2 signaling by self-induced degradation. J Biol Chem (2002) 1.23
Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med (2007) 1.17
Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation. J Immunol (1999) 1.15
Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med (2007) 1.10
Discrete signaling regions in the lymphotoxin-beta receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-kappaB pathways. J Biol Chem (2000) 1.09
Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. J Biol Chem (1997) 1.07
Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes. J Immunol (2005) 0.98
TRAF2 plays a key, nonredundant role in LIGHT-lymphotoxin beta receptor signaling. Mol Cell Biol (2005) 0.96
An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha. J Immunol (2007) 0.89
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int (2002) 8.03
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (2014) 5.47
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest (2002) 4.64
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain (2011) 3.38
BAFF: a fundamental survival factor for B cells. Nat Rev Immunol (2002) 2.94
A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell (2009) 2.64
Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell (2012) 2.50
TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron (2005) 2.39
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood (2011) 2.33
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther (2012) 2.22
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat Rev Immunol (2003) 2.10
Rheumatology outcomes: the patient's perspective. J Rheumatol (2003) 1.87
Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol (2006) 1.85
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol (2007) 1.79
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
Ankylosing spondylitis and its impact on sexual relationships. Rheumatology (Oxford) (2009) 1.53
T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol (2006) 1.51
Nurse and allied health professional consultants: perceptions and experiences of the role. J Clin Nurs (2011) 1.50
Outcomes generated by patients with rheumatoid arthritis: how important are they? Musculoskeletal Care (2005) 1.46
Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology (2012) 1.43
Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Nat Immunol (2012) 1.40
Effective pain management for patients with arthritis. Nurs Stand (2004) 1.39
Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. MAbs (2009) 1.30
Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. J Clin Invest (2011) 1.22
Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives. J Autoimmun (2008) 1.20
Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor. J Biol Chem (2007) 1.14
Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J Biol Chem (2007) 1.14
Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation (2005) 1.11
A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis. J Immunol (2003) 1.09
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg Med Chem (2013) 1.07
Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710. J Immunol (2014) 1.06
Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic mice. Arthritis Res Ther (2009) 1.04
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res (2006) 1.01
A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT. J Clin Invest (2003) 0.99
Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. J Clin Invest (2002) 0.97
Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome. Arthritis Res Ther (2011) 0.91
The educational needs of nurses and allied healthcare professionals caring for people with arthritis: results from a cross-sectional survey. Musculoskeletal Care (2012) 0.87
A randomised, controlled study of outcome and cost effectiveness for RA patients attending nurse-led rheumatology clinics: study protocol of an ongoing nationwide multi-centre study. Int J Nurs Stud (2011) 0.86
Exploring the healthcare journey of patients with rheumatoid arthritis: a mapping project - implications for practice. Musculoskeletal Care (2008) 0.85
Patient experiences, attitudes and expectations towards receiving information about anti-TNF medication--"It could give me two heads and I'd still try it!". BMC Musculoskelet Disord (2013) 0.84
Implementing the NICE osteoarthritis guidelines: a mixed methods study and cluster randomised trial of a model osteoarthritis consultation in primary care--the Management of OsteoArthritis In Consultations (MOSAICS) study protocol. Implement Sci (2014) 0.84
Topology of gene expression networks as revealed by data mining and modeling. Bioinformatics (2003) 0.83
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest (2016) 0.83
LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. Adv Exp Med Biol (2011) 0.82
The role of social comparison in coping with rheumatoid arthritis: an interview study. Musculoskeletal Care (2004) 0.81
Elevated body mass index (BMI) does not adversely affect in vitro fertilization outcome in young women. J Assist Reprod Genet (2008) 0.81
Lymphotoxin β receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-κB activation. Carcinogenesis (2013) 0.80
Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis. PLoS One (2013) 0.79
An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours. Eur J Cancer (2011) 0.79
Defining the content of an opportunistic osteoarthritis consultation with primary health care professionals: a Delphi consensus study. Arthritis Care Res (Hoboken) (2013) 0.79
CT-guided nucleoplasty with radiofrequency energy for the treatment of lumbar disk herniation. J Spinal Disord Tech (2015) 0.78
Operations research methods applied to workflow in a medical records department. Health Care Manag Sci (2002) 0.76
Biology of subjectivity in chronic diseases. Rheumatology (Oxford) (2013) 0.75
A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds. J Org Chem (2010) 0.75
Increased intracranial pressure is associated with elevated cerebrospinal fluid ADH levels in closed-head injury. Neurol Res (2010) 0.75
A case report of evidence-based practice: from academia to clinic. Am J Occup Ther (2007) 0.75
Continuing professional development: issues raised by nurses and allied health professionals working in musculoskeletal settings. Musculoskeletal Care (2012) 0.75
The continuing professional development for nurses and allied health professionals working within musculoskeletal services: a national UK survey. Musculoskeletal Care (2012) 0.75
Workshop summary: control of lymphocyte function and repertoire by the TNF superfamily. Adv Exp Med Biol (2011) 0.75
Musculoskeletal Care: the journey continues ... Musculoskeletal Care (2010) 0.75
Engagement with continuing professional development: development of a service model. J Allied Health (2012) 0.75