Published in Curr Biol on February 25, 2010
A novel role for greatwall kinase in recovery from DNA damage. Cell Cycle (2010) 1.68
Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell (2011) 1.43
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Rep (2010) 1.10
HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells. Cancer Lett (2010) 1.06
What goes on must come off: phosphatases gate-crash the DNA damage response. Trends Biochem Sci (2011) 0.97
Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One (2013) 0.94
Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery. J Biol Chem (2011) 0.92
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation. PLoS One (2013) 0.81
Response to DNA damage: why do we need to focus on protein phosphatases? Front Oncol (2013) 0.81
Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase). Mol Cell Proteomics (2013) 0.80
Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α. Cell Cycle (2015) 0.79
Monoclonal antibodies against Xenopus greatwall kinase. Hybridoma (Larchmt) (2011) 0.79
Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits. Nucleic Acids Res (2015) 0.79
DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol (2015) 0.79
Phosphatase 1 nuclear targeting subunit is an essential regulator of M-phase entry, maintenance, and exit. J Biol Chem (2014) 0.78
Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs. PLoS One (2014) 0.78
Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response. Sci Rep (2016) 0.77
Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes. Mol Cell Biol (2014) 0.77
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance. Cell Cycle (2015) 0.75
Repo-Man/PP1 regulates heterochromatin formation in interphase. Nat Commun (2017) 0.75
CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients. Oncotarget (2017) 0.75
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
From promiscuity to precision: protein phosphatases get a makeover. Mol Cell (2009) 4.17
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat (2001) 3.77
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell (2005) 3.24
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J (2009) 2.78
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One (2007) 2.77
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. J Biol Chem (2001) 2.54
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol (2006) 2.33
Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol (2007) 2.28
Chromosome breakage after G2 checkpoint release. J Cell Biol (2007) 2.25
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep (2008) 2.09
The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev (2008) 2.06
DNA damage checkpoint and repair centers. Curr Opin Cell Biol (2004) 1.99
Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis. EMBO J (1997) 1.85
The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio. Dev Cell (2004) 1.68
Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends. Mol Biol Cell (2000) 1.55
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO J (2003) 1.50
Rapid activation of ATM on DNA flanking double-strand breaks. Nat Cell Biol (2007) 1.49
Protein phosphatase 4--from obscurity to vital functions. FEBS Lett (2005) 1.41
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J (2004) 1.38
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (2007) 1.27
Altered expression of cell cycle genes distinguishes aggressive neuroblastoma. Oncogene (2005) 1.26
Multiple roles for protein phosphatase 1 in regulating the Xenopus early embryonic cell cycle. Mol Biol Cell (1992) 1.22
Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle (2007) 1.21
Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer Res (2003) 1.07
Drug target discovery by gene expression analysis: cell cycle genes. Curr Cancer Drug Targets (2001) 1.02
Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods (2007) 0.99
Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. Mol Cell Biol (2007) 0.97
DNA-damage checkpoints: location, location, location. Trends Cell Biol (2008) 0.87
Cell signalling and radiation survival: the impact of protein phosphatases. Int J Radiat Biol (2009) 0.77
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
A novel mechanism for activation of the protein kinase Aurora A. Curr Biol (2003) 2.68
Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem (2006) 2.47
TGF-β upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest (2012) 2.44
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis. Am J Respir Crit Care Med (2004) 2.42
Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res (2007) 2.28
Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast Cancer Res (2006) 2.20
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12
Calcium, calmodulin, and CaMKII requirement for initiation of centrosome duplication in Xenopus egg extracts. Science (2002) 2.03
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest (2009) 2.01
Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol (2009) 1.90
A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science (2004) 1.90
Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs. Genes Dev (2003) 1.80
The TGF-beta paradox in human cancer: an update. Future Oncol (2009) 1.79
Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. Cancer Res (2006) 1.69
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. Carcinogenesis (2008) 1.69
A novel role for greatwall kinase in recovery from DNA damage. Cell Cycle (2010) 1.68
The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio. Dev Cell (2004) 1.68
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast Cancer Res (2009) 1.67
Transforming growth factor-β and the hallmarks of cancer. Cell Signal (2010) 1.66
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Mol Biol Cell (2011) 1.66
SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system. Mol Biol Cell (2003) 1.63
Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta. Carcinogenesis (2008) 1.62
Regulation of Xenopus Aurora A activation by TPX2. J Biol Chem (2003) 1.58
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem (2002) 1.53
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53
Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor. Curr Biol (2005) 1.48
Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res (2008) 1.47
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis (2008) 1.45
Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia (2011) 1.39
Noncanonical TGF-β signaling during mammary tumorigenesis. J Mammary Gland Biol Neoplasia (2011) 1.38
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem (2009) 1.37
Role of transforming growth factor-beta in cancer progression. Future Oncol (2006) 1.34
The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor. Curr Biol (2002) 1.34
Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling. Mol Biol Cell (2004) 1.29
Spindle pole regulation by a discrete Eg5-interacting domain in TPX2. Curr Biol (2008) 1.26
Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol (2008) 1.26
Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells. DNA Cell Biol (2004) 1.20
Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors. FASEB J (2009) 1.20
Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Mol Cancer Res (2004) 1.19
The relevance of the TGF-β Paradox to EMT-MET programs. Cancer Lett (2013) 1.18
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res (2010) 1.16
Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis. Angiogenesis (2007) 1.15
Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway. J Biol Chem (2013) 1.15
Cyclin E-dependent localization of MCM5 regulates centrosome duplication. J Cell Sci (2008) 1.13
The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta. Breast Cancer Res (2005) 1.10
The role of Xenopus membrane progesterone receptor beta in mediating the effect of progesterone on oocyte maturation. Mol Endocrinol (2006) 1.10
Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography. Mol Cell Proteomics (2003) 1.10
Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells. Neoplasia (2011) 1.09
NetSlim: high-confidence curated signaling maps. Database (Oxford) (2011) 1.09
Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. Microvasc Res (2008) 1.08
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest. J Cell Biol (2003) 1.08
The polo box is required for multiple functions of Plx1 in mitosis. J Biol Chem (2004) 1.06
Fibulin-5 function during tumorigenesis. Future Oncol (2005) 1.05
The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. J Cell Sci (2010) 1.05
Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells. Mol Cell Biol (2004) 1.05
Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase. Oncogene (2005) 1.04
Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. Cell Cycle (2009) 1.03
Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β. Mol Biol Cell (2013) 1.02
PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. FASEB J (2009) 1.02
Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies? Expert Rev Anticancer Ther (2007) 0.98
X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression. J Biol Chem (2009) 0.98
Role of TGF-β and the tumor microenvironment during mammary tumorigenesis. Gene Expr (2011) 0.97
Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. Mol Cell Biol (2007) 0.97
Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation. Curr Biol (2011) 0.97
In vivo dual substrate bioluminescent imaging. J Vis Exp (2011) 0.97
Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT. Breast Cancer Res (2013) 0.96
Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. J Invest Dermatol (2004) 0.96
A feedback loop in the polo-like kinase activation pathway. J Biol Chem (2004) 0.95
Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J (2013) 0.95
The anaphase-promoting complex/cyclosome inhibitor Emi2 is essential for meiotic but not mitotic cell cycles. J Biol Chem (2006) 0.94
Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers. Breast Cancer Res (2014) 0.94
The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells. Cells Tissues Organs (2010) 0.94
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding. Proc Natl Acad Sci U S A (2010) 0.93
Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells. Breast Cancer Res Treat (2013) 0.93
Regulation of Greatwall kinase during Xenopus oocyte maturation. Mol Biol Cell (2011) 0.92
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem (2005) 0.92
The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2. Cell Cycle (2005) 0.91
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Mol Biol Cell (2011) 0.90
Centrosomal localization of cyclin E-Cdk2 is required for initiation of DNA synthesis. Curr Biol (2010) 0.88
Metaphase arrest by cyclin E-Cdk2 requires the spindle-checkpoint kinase Mps1. Curr Biol (2006) 0.88
Fibulin-5 promotes wound healing in vivo. J Am Coll Surg (2004) 0.86
Epithelial-mesenchymal transition in tumor metastasis: a method to the madness. Future Oncol (2009) 0.86
Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling. BMC Cell Biol (2004) 0.85
Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes. J Biol Chem (2009) 0.84
Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancer. Transl Oncol (2009) 0.84
A role for G1/S cyclin-dependent protein kinases in the apoptotic response to ionizing radiation. J Biol Chem (2002) 0.83