Published in EMBO Rep on August 29, 2008
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell (2009) 4.17
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature (2014) 2.67
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res (2010) 2.12
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J (2012) 1.91
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol (2010) 1.73
Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol (2010) 1.45
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem (2010) 1.34
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 1.34
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J Biol Chem (2008) 1.31
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control. Cell Cycle (2010) 1.27
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J (2009) 1.22
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol (2010) 1.19
Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res (2010) 1.18
Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. PLoS One (2009) 1.18
MDC1: The art of keeping things in focus. Chromosoma (2010) 1.15
Histone phosphorylation: a chromatin modification involved in diverse nuclear events. Epigenetics (2012) 1.14
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13
Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Curr Biol (2010) 1.13
Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell (2014) 1.05
Loss, mutation and deregulation of L3MBTL4 in breast cancers. Mol Cancer (2010) 1.04
Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A (2014) 1.01
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal (2011) 0.99
Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication. Mol Cell Biol (2010) 0.97
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
Chromatin at the intersection of viral infection and DNA damage. Biochim Biophys Acta (2009) 0.97
What goes on must come off: phosphatases gate-crash the DNA damage response. Trends Biochem Sci (2011) 0.97
Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc Natl Acad Sci U S A (2010) 0.96
Chromatin modifications and DNA repair: beyond double-strand breaks. Front Genet (2014) 0.96
H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues. Clin Epigenetics (2011) 0.94
Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. J Biol Chem (2012) 0.93
Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair. Mol Biol Cell (2010) 0.93
Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle (2011) 0.90
When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage. Syst Synth Biol (2014) 0.89
Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells. Leuk Res (2009) 0.89
Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. J Biol Chem (2009) 0.89
Nucleosome dynamics as modular systems that integrate DNA damage and repair. Cold Spring Harb Perspect Biol (2013) 0.89
A prognostic signature of G(2) checkpoint function in melanoma cell lines. Cell Cycle (2013) 0.86
Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev (2012) 0.86
Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis. J Biol Chem (2013) 0.86
Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage. PLoS One (2012) 0.86
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet (2015) 0.85
The role of dietary histone deacetylases (HDACs) inhibitors in health and disease. Nutrients (2014) 0.85
DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. Cytometry A (2009) 0.85
Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo. Cancer Res (2011) 0.84
Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage. EMBO Rep (2010) 0.84
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing. Nat Commun (2014) 0.83
Double-strand breaks and the concept of short- and long-term epigenetic memory. Chromosoma (2010) 0.82
Quantification of gammaH2AX foci in response to ionising radiation. J Vis Exp (2010) 0.81
Response to DNA damage: why do we need to focus on protein phosphatases? Front Oncol (2013) 0.81
TPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response. PLoS One (2014) 0.81
Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of γH2AX following treatment with ionizing radiation. Cell Cycle (2013) 0.81
TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS One (2015) 0.79
Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol (2012) 0.79
Protein phosphatase Pph3 and its regulatory subunit Psy2 regulate Rad53 dephosphorylation and cell morphogenesis during recovery from DNA damage in Candida albicans. Eukaryot Cell (2011) 0.79
sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways. Oncotarget (2015) 0.79
The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1α and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways. Oncotarget (2014) 0.79
DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia. Int J Mol Sci (2015) 0.79
Riccardin D Exerts Its Antitumor Activity by Inducing DNA Damage in PC-3 Prostate Cancer Cells In Vitro and In Vivo. PLoS One (2013) 0.77
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity. Cell Biosci (2014) 0.77
PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One (2014) 0.76
The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination. PLoS One (2013) 0.76
T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4. Cell Cycle (2016) 0.76
Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. J Biol Chem (2016) 0.75
Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice. J Radiat Res (2016) 0.75
Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila. Cell Death Dis (2017) 0.75
Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions. Mol Cells (2015) 0.75
Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus. Sci Rep (2016) 0.75
A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity. Genetics (2016) 0.75
PLATINUM SENSITIVE 2 LIKE impacts growth, root morphology, seed set, and stress responses. PLoS One (2017) 0.75
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol (2000) 9.21
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell (2005) 3.24
Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis. Mol Cell Biol (1991) 2.60
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J (2004) 2.19
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics (2005) 1.95
Protein serine/threonine phosphatases; an expanding family. FEBS Lett (1990) 1.86
PPX, a novel protein serine/threonine phosphatase localized to centrosomes. EMBO J (1993) 1.80
The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle. Eur J Biochem (1985) 1.41
A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay. Mutat Res (2000) 1.35
Chromatin disassembly and reassembly during DNA repair. Mutat Res (2007) 0.95
The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. J Biol Chem (2002) 0.92
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
The genetic landscape of a cell. Science (2010) 16.52
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (2007) 5.08
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A (2001) 4.16
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell (2013) 3.55
SAINT: probabilistic scoring of affinity purification-mass spectrometry data. Nat Methods (2010) 3.50
Regulation of DNA damage responses by ubiquitin and SUMO. Mol Cell (2013) 3.43
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions. Science (2014) 3.31
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell (2006) 2.71
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature (2013) 2.64
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Regulatory ubiquitylation in response to DNA double-strand breaks. DNA Repair (Amst) (2009) 2.17
Simultaneous DNA amplification and detection using a pH-sensing semiconductor system. Nat Methods (2013) 2.13
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol Cell (2005) 2.09
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle (2011) 1.97
The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair (Amst) (2010) 1.94
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science (2009) 1.91
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol (2003) 1.88
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J (2010) 1.75
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Global gene deletion analysis exploring yeast filamentous growth. Science (2012) 1.67
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol Cell (2012) 1.62
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Nat Cell Biol (2014) 1.55
Affinity-purification mass spectrometry (AP-MS) of serine/threonine phosphatases. Methods (2007) 1.51
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
Problems with co-funding in Canada. Science (2005) 1.48
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Mol Cell Biol (2002) 1.42
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods (2013) 1.41
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. J Exp Med (2010) 1.40
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell (2010) 1.38
OpenFreezer: a reagent information management software system. Nat Methods (2011) 1.35
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics (2006) 1.33
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell (2010) 1.32
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J Biol Chem (2008) 1.31
Affinity-purification coupled to mass spectrometry: basic principles and strategies. Proteomics (2012) 1.30
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem (2011) 1.26
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Rep (2012) 1.24
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics (2011) 1.24
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A (2009) 1.24
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev (2010) 1.22
Analyzing protein-protein interactions from affinity purification-mass spectrometry data with SAINT. Curr Protoc Bioinformatics (2012) 1.20
Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell (2013) 1.11
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci (2006) 1.11
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell (2008) 1.10
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol (2012) 1.09
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet (2007) 1.06
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem (2011) 1.05
CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol (2010) 1.05
Label-free quantitative proteomics trends for protein-protein interactions. J Proteomics (2012) 1.01
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Mol Cell Proteomics (2012) 1.00
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med (2011) 1.00
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res (2013) 1.00
Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol Biol Cell (2012) 1.00
Analysis of protein complexes through model-based biclustering of label-free quantitative AP-MS data. Mol Syst Biol (2010) 0.99
A cost-benefit analysis of multidimensional fractionation of affinity purification-mass spectrometry samples. Proteomics (2011) 0.97
A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration. Mol Cell Biol (2010) 0.97
Mass spectrometry approaches to study mammalian kinase and phosphatase associated proteins. Methods (2012) 0.96
Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. Mol Cell Proteomics (2006) 0.96
Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. PLoS Pathog (2012) 0.95
gammaH2AX as a checkpoint maintenance signal. Cell Cycle (2006) 0.93