PubRank

Alexandra C Newton

Author PubWeight™ 107.02‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 2002 18.89
2 PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005 8.22
3 PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007 6.00
4 The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008 4.49
5 A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 2003 4.38
6 The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem 2007 2.24
7 Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell 2010 2.22
8 Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem 2006 1.99
9 Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem 2004 1.96
10 PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res 2010 1.93
11 PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab 2008 1.92
12 Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell 2011 1.74
13 A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem 2006 1.69
14 Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J 2002 1.65
15 AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell 2008 1.57
16 Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem 2006 1.56
17 The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem 2002 1.52
18 The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem 2008 1.47
19 The life and death of protein kinase C. Curr Drug Targets 2008 1.46
20 Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem 2005 1.37
21 Protein kinase C pharmacology: refining the toolbox. Biochem J 2013 1.27
22 Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci 2011 1.26
23 Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J 2012 1.23
24 Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem 2012 1.21
25 Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A 2010 1.20
26 Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J Biol Chem 2003 1.15
27 Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life 2003 1.13
28 Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem 2009 1.11
29 Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem 2007 1.07
30 Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life 2008 1.06
31 The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem 2004 1.05
32 Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol 2011 1.04
33 The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem 2009 1.04
34 Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem 2011 1.04
35 Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry 2003 1.02
36 Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem 2011 1.02
37 A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A 2003 1.01
38 Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem 2010 0.99
39 Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem 2011 0.98
40 Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem 2006 0.98
41 Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. J Biol Chem 2011 0.96
42 Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem 2011 0.96
43 Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem 2011 0.95
44 Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem 2011 0.95
45 Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem 2010 0.93
46 Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem 2010 0.90
47 Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. J Biol Chem 2008 0.89
48 Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem 2012 0.87
49 Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. J Biol Chem 2012 0.86
50 Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem 2014 0.85
51 Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J 2003 0.84
52 Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. J Biol Chem 2013 0.83
53 Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. J Org Chem 2003 0.82
54 Shedding light on local kinase activation. BMC Biol 2012 0.81
55 Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol 2009 0.81
56 Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics 2013 0.81
57 Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods Mol Biol 2003 0.80
58 Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol 2012 0.79
59 Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol 2011 0.78
60 Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods Mol Biol 2003 0.76
61 Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry 2014 0.76
62 Imaging kinase activity at protein scaffolds. Methods Mol Biol 2014 0.75